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Front. Pharmacol. | doi: 10.3389/fphar.2019.01405

A Novel Antimicrobial-phytochemical Conjugate with Antimicrobial Activity against Streptococcus uberis, Enterococcus faecium and Enterococcus faecalis

  • 1University of Saskatchewan, Canada

Antimicrobial resistance is one of the major threats to human and animal health. An effective strategy to reduce and/or delay antimicrobial resistance is to use combination therapies. Research in our laboratory has been focused on combination therapies of antimicrobials and phytochemicals and development of antimicrobial-phytochemical conjugates. In this study, we report the synthesis and antimicrobial activity of a novel sulfamethoxazole-gallic acid conjugate compound (Hybrid 1). Hybrid 1 not only showed much stronger activity than sulfamethoxazole towards Streptococcus uberis 19436, Enterococcus faecium 700221 and Enterococcus faecalis 29212, which were purchased from American Type Culture Collection (ATCC), but also exhibited a promising antimicrobial effect against two Enterococcus faecalis clinical isolates, one of which was multidrug resistant. Further studies are warranted to establish the in vivo antimicrobial activity for Hybrid 1 and develop more potent sulfamethoxazole-gallic acid based antimicrobial conjugates using Hybrid 1 as a lead compound.

Keywords: antibiotic resistance, minimum inhibitory concentration, chemical synthesis, Streptococcus, antimicrobial-phytochemical conjugate, Enterococcus

Received: 14 Aug 2019; Accepted: 05 Nov 2019.

Copyright: © 2019 Yang, Rajamanickam and Sakharkar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jian Yang, University of Saskatchewan, Saskatoon, Canada,