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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01421

Dermaseptins, multifunctional antimicrobial peptides: A review of their pharmacology, effectivity, mechanism of action, and possible future directions

 Emiel J. Bartels1*,  Mohamed Amiche2 and Douwe Dekker3, 4*
  • 1Utrecht University, Netherlands
  • 2Université Paris-Est Créteil Val de Marne, France
  • 3University Medical Center Utrecht, Netherlands
  • 4National Poisons Information Center (NVIC), Netherlands

Peptides produced by animals could be an inspiration for biopharmaceutical drugs. Dermaseptins, multifunctional antimicrobial peptides, isolated from the Amazonian tree-frog of Phyllomedusa genus, are a group of α-helical shaped polycationic peptides that show effectivity in vitro against bacteria, parasites, protozoa, viruses and tumors and without effects on normal eukaryote cells. However, no clinical trials have been conducted thus far. This systematic review summarizes the current knowledge on the pharmacology, effectivity against infectious pathogens and tumors cells and the mechanism of action of the Dermaseptins. Gaps in this knowledge remain: a unifying mechanism of action, the effectivity of Dermaseptins against several cancer cell lines and safety in humans. Potential future applications include: antiseptic topical ointments, early interfering anti-viral medicine, anti-conceptive, anti-tumor agent and an alternative to plant pesticides through applied biotechnology.

Keywords: Dermaseptin, Phyllomedusa bicolor, Antimicrobial peptide, amphibian, Infectious, tumor

Received: 22 Apr 2019; Accepted: 07 Nov 2019.

Copyright: © 2019 Bartels, Amiche and Dekker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. Emiel J. Bartels, Utrecht University, Utrecht, Netherlands, e.j.h.bartels@students.uu.nl
MD, PhD. Douwe Dekker, University Medical Center Utrecht, Utrecht, 3584, Netherlands, Netherlands, D.Dekker@umcutrecht.nl