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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01422

Ameliorative Effects of Suhuang Antitussive Capsule on LPS-Induced Sputum Obstruction in Mice through Promoting HGF Secretion via an Intestinal Endocrine-Dependent Pathway

 Ninghua Tan1*, Xiyang Tong2, Rongyao Liang2, Yuning Jia3,  Weiwei Qin2, Chao Guo2, Xingdong Wu2, Zhen Wang2 and Dong Chen3
  • 1China Pharmaceutical University, China
  • 2State Key Laboratory of Natural Medicines, China Pharmaceutical University, China
  • 3Beijing Haiyan Pharmaceutical Co., Ltd.,, China

Sputum obstruction is one of common cough complications, which is tightly associated with airway inflammation. Suhuang antitussive Capsule (SH Capsule), a classic traditional Chinese medicine prescription, has been used for the treatment of post-cold cough and cough variant asthma in the long clinical application. This study aims to investigate the effects and underlying mechanisms of SH Capsule on LPS-induced sputum obstruction in mice. The results showed that SH Capsule effectively promoted the tracheal phenol red output and mucociliary clearance. SH Capsule also alleviated airway inflammation-mediated MUC5AC level through EGFR-ERK signaling. A further in vivo analysis showed that HGF inhibitor SU11274 abrogated the effects of SH Capsule on MUC5AC, well demonstrating that HGF was required for the beneficial effects of SH Capsule on expectoration in vivo. Moreover, SH Capsule promoted HGF secretion in a colon-dependent manner, which reached lung tissues via blood circulation. Collectively, this study provided new pharmacological data for clinical use of SH Capsule, and proposed a novel mechanism by which SH Capsule was pharmacologically promising for treating sputum obstruction.

Keywords: Suhuang antitussive Capsule, MUC5AC, HGF, sputum obstruction, airway inflammation

Received: 15 Jul 2019; Accepted: 07 Nov 2019.

Copyright: © 2019 Tan, Tong, Liang, Jia, Qin, Guo, Wu, Wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Ninghua Tan, China Pharmaceutical University, Nanjing, China, nhtan@cpu.edu.cn