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Front. Psychiatry | doi: 10.3389/fpsyt.2017.00241

Dietary n-3 Polyunsaturated Fatty Acids in Late Pregnancy and Postpartum Depressive Symptom among Japanese Women

 Minatsu Kobayashi1,  Kohei Ogawa2,  Naho Morisaki3, Yukako Tani4, Reiko Horikawa5 and  Takeo Fujiwara4*
  • 1Department of Food Science, Faculty of Home Economics, Otsuma Women's University, Japan
  • 2Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center For Child Health and Development, Japan
  • 3Department of Social Medicine, National Research Institute for Child Health and Development, Japan
  • 4Department of Global Health Promotion, Tokyo Medical and Dental University, Japan
  • 5Division of Endocrinology and Metabolism, National Center For Child Health and Development, Japan

Background: The use of n-3 poly-unsaturated fatty acids (n-3PUFA) in preventive or therapeutic modalities for postpartum depression, especially long-chain types such as eicosapentaenoic acid (EPA) and a docosahexaenoic acid (DHA), is of considerable interest. High n-3PUFA consumption has been reported among pregnant Japanese women. Therefore, analysis of this group could provide important insights into the relationship between postpartum depression and dietary n-3PUFA consumption. To further examine the relationship between the risk of postpartum depression and n-3PUFA consumption, we conducted a prospective hospital-based birth cohort study in Japan.
Design and Methods: Our prospective birth cohort study was performed at the National Center for Child Health and Development (NCCHD) in suburban Tokyo, Japan. Dietary n-3PUFA intake during late pregnancy was assessed by a semi-quantitative food questionnaire and participants were categorized by quintile distributions of n-3PUFA intake. A Japanese translation of the Edinburgh Postnatal Depression Scale was used to screen women for postpartum depression at one month after delivery (967 women) and at six months after delivery (710 women). We performed logistic regression analysis to examine the relationship between the risk of postpartum depression and n-3PUFA consumption after adjusting for confounding factors.
Results: Significant associations between EPA, DHA and n-3PUFA intakes in late pregnancy and postpartum depression at both one month and six months after delivery were not observed.
Conclusions: This prospective study indicated that EPA, DHA and n-3PUFA intake during late pregnancy was not associated with the risk of postpartum depression.

Keywords: Fish intake, Dietary n-3 polyunsaturated fatty acids, Eicosapentaenoic Acid, docosahexaenoic acid, postpartum depression, Japanese pregnant women

Received: 16 Aug 2017; Accepted: 06 Nov 2017.

Edited by:

Shervin Assari, University of Michigan, United States

Reviewed by:

Leandro D. Valiengo, University of São Paulo, Brazil
Andreas Hoell, Zentralinstitut für Seelische Gesundheit, Germany  

Copyright: © 2017 Kobayashi, Ogawa, Morisaki, Tani, Horikawa and Fujiwara. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Takeo Fujiwara, Tokyo Medical and Dental University, Department of Global Health Promotion, 1-5-45, Yushima, Bunkyō, 113-8519, Tokyo, Japan, fujiwara.hlth@tmd.ac.jp