Original Research ARTICLE
Prevalence of Cigarette Smoking and Nicotine Dependence in Men and Women Residing in Two Provinces in China
- 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine, Hangzhou, China
- 2Shanxi Key Laboratory of Environmental Veterinary Medicine, Shanxi Agricultural University, Taigu, China
- 3ACT Center for Tobacco Treatment, Education and Research, Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, United States
- 4Research Center for Air Pollution and Health, Zhejiang University, Hangzhou, China
- 5Institute of NeuroImmune Pharmacology, Seton Hall University, South Orange, NJ, United Sates
Aims: Although it is known that there is a high smoking prevalence among Chinese, key issues such as social and environmental factors impacting smoking initiation and persistence, the percentage of smokers considered nicotine dependence (ND), and the availability and use of ND treatments have rarely been investigated.
Methods: To address these issues, from 2012 to 2014, we conducted a large-scale study in the Zhejiang and Shanxi provinces of China using the Fagerström Test for Nicotine Dependence and other validated questionnaires.
Results: Of the 17,057 subjects, consisting of 13,476 males and 3,581 females aged 15 years or older, the prevalence of male smoking was 66.1% [95% confidence interval (CI) 65.5%, 66.9%] and that of female smoking was 3.2% (95% CI 3.0%, 3.8%). Among males, 25.8% (95% CI 25.0%, 26.5%) were low-to-moderate ND, and 11.8% (95% CI 11.2%, 12.3%) were high ND (H-ND), persons who have significant difficulty quitting without treatment. The degrees of ND were related to age, extent of education, and annual family income. The social–environmental factors examined conveyed a higher risk for smoking initiation, which is particularly true for the influence of smoking by friends. Furthermore, current smokers had a significantly higher risk of suffering respiratory and digestive symptoms.
Conclusion: These data not only show a high smoking prevalence in Chinese men but also reveal that a relatively large number of smokers are H-ND. Considering that few Chinese smokers seek ND treatment, a comprehensive smoking prevention and treatment program designed specifically for Chinese is greatly needed.
As the largest tobacco-consuming country in the world, the prevalence of cigarette smoking in China remains high, especially in the male population (1). Currently, China is facing an immense public health challenge from tobacco smoking, with about 1.4 million deaths resulting from cigarette smoking in 2010 (2). This number is expected to increase to 2 million by 2030 and 3 million by 2050 if smoking patterns are not altered (3).
The economic burden caused by tobacco smoking in China has increased substantially during the past decade. In 2008, approximately US$6.2 billion was spent for direct smoking-attributable health care costs and US$22.7 billion was spent for indirect economic costs, a rise of 154 and 376%, respectively, in comparison with costs in 2000 (4). Although in 2005, China ratified the treaty of the WHO Framework Convention on Tobacco Control (FCTC) to make progress on smoking prevention and reduction (5), the country is still in the early stage of addressing the threat from cigarette smoking, with significant gaps still present in the response to the requirements of FCTC (6).
Prevention of smoking initiation and promotion of smoking cessation remain important ways of tobacco control (6–8). Although many smokers want to quit, only a few succeed (9–11). Various genetic, social, and psychological factors have been implicated in difficulties achieving and maintaining cessation (12–16). One of the key inhibiting factors is physical dependence on nicotine (17). The epidemic of nicotine dependence (ND) harbors enormous harmful effects on the health of smokers. Accumulating evidence (18–21) demonstrates that time to the first cigarette of the day, one of the best indicators of ND (22), correlates with higher extents of smoking relapse, greater withdrawal symptoms, continued nicotine intake, tobacco-related carcinogen exposure, and cancer risk in both adolescent and adult smokers.
Another important factor preventing abstinence is the social conventions in China, where smoking has long had a positive and attractive image (6, 23). Many Chinese smokers do not fully understand the adverse consequences of tobacco smoking. At almost all social events, such as weddings, funerals, and official activities, cigarettes are considered an essential supply for all attendees, especially in rural areas (6). It is a courtesy to offer cigarettes to friends, guests, or visitors; and in 2010, only 23.2% of Chinese adults believed that cigarette smoking leads to stroke, heart attack, and lung cancer (24). Thus, it is urgent to raise public awareness of the harmful consequences of smoking and to increase the government’s incentives to take steps to reduce the high smoking rate in China.
Although several studies have documented the prevalence of smoking among Chinese adults (1, 9, 23, 25, 26), none has broadly examined the prevalence of ND. To address this issue and provide information that has implications for tobacco control, we conducted a large-scale, cross-sectional study of tobacco use among adults by employing a well-accepted standardized questionnaire. Furthermore, we evaluated the association of social-environmental factors with cigarette smoking, as well as adverse effects of cigarette smoking on health.
Materials and Methods
From June 2012 to January 2014, a total of 17,057 persons consisting of 3,581 women and 13,476 men participated in the study. All participants, who were at least 15 years old and visited the hospital for their annual healthy examinations, were invited to participate in the study in their local community hospitals in the southern Zhejiang Province and the northern Shanxi Province of China. We informed each potential participants about the purpose of this study, which was to investigate the epidemic of smoking and ND in Chinese males and females. Demographic characteristics, namely age, sex, education, marital status, annual family income, number of cohabiting family members, smoking status, and medical history, were obtained from each participant, which was conducted as we did in our recruitment of Mid-South Tobacco Family study and Mid-South Tobacco Case–Control Study in the US from 1999 to 2012 (27–30). All subjects who agreed to participate in the study were face-to-face interviewed according to the protocol by local physicians and nurses of each hospital, who were trained by senior investigators of the research team prior to start their involvement of the study. All subjects received a water cup (value about US$2.00) as an appreciation of their participation and time. The Institutional Review Board of the First Affiliated Hospital of Zhejiang University approved the study, and written consent was obtained from all participants.
Classification of Cigarette Smoking and Dependence on Nicotine
Following the definition of regular smokers commonly used in the tobacco field (31, 32), we defined current smokers as those who had smoked at least 100 cigarettes in their lifetimes and smoked either daily or occasionally at the time of the survey. Former smokers were defined as those who had smoked at least 100 cigarettes but had not smoked for at least 1 year prior to the survey (31, 32). Non-smokers were defined as those who had smoked fewer than 100 cigarettes in their lifetimes. For current and former smokers, we also collected smoking-related information, including age at which they began regular smoking, the location of initial smoking (school, workplace, home, or others), the people who were present at their initial smoking episode (peers, family members, or alone), parent and other family member smoking status, and the percentage of friends who smoked.
Nicotine dependence was evaluated by the Fagerström Test for Nicotine Dependence (FTND) (33) in a Chinese-translated version, which has been documented to be a useful instrument for evaluating ND in Chinese adults (34, 35). To characterize the ND status of each smoker, we categorized smokers into the following three subgroups based on FTND score: very low ND (VL-ND; FTND 0–2), low-to-moderate ND (LM-ND; FTND 3–5), and high ND (H-ND; FTND 6–10) (36), with a goal of achieving an approximately equal sample size of each group.
Respiratory and Digestive Symptoms
Because of the coal mining in the Shanxi Province where part of the survey was conducted, all participants from this province (n = 6,112) were also surveyed for their respiratory and digestive symptoms. We classified participants as individuals with respiratory symptoms according to their answers to the following questions (37): “Did you have any of the following respiratory symptoms in the most recent year?” The options for this question were six kinds of symptoms; i.e., cough, phlegm, chest pain, dyspnea, nasosinusitis, and chronic pharyngitis. Similarly, participants were considered as patients with digestive symptoms according to their answer to the question: “Did you have any of the following digestive symptoms in the most recent year?” There were four kinds of digestive symptoms, namely, nausea, anorexia, acid regurgitation, and stomach cold.
All data were entered in Epidata 3 independently by two researchers and then double-checked by comparing the entries, with correction of all inconsistent entries before performing any statistical analysis. Differences between proportions among groups were compared for significance with the Chi-square test. Logistic regression analysis was performed to identify the factors associated with smoking and the adverse effect of smoking on the respiratory and digestive systems. All multivariate regression models were adjusted for age, marital status, extent of education, annual family income, and body mass index (BMI), as well as for social-environmental factors. Furthermore, to avoid any potential confounding factor related to respiratory or digestive symptoms, we purposely selected a subgroup of individuals who were free from any respiratory or digestive symptom as a reference control for our analyses. All statistical analyses were conducted with SAS statistical software (version 9.1.3) for Windows (SAS Institute Inc., Cary, NC), and P < 0.05 was considered statistically significant.
Demographic Characteristics of Participants
There were 17,955 Han Chinese invited to participate the study; of them, 17,057 participants were enrolled into the study. Of all participants, 13,476 (79.0%) were men and 3,581 (21.0%) were women. The participants had an average age of 42.7 years (±12.8 SD) and a mean BMI of 23.8 (±3.2) kg/m2, and 87% were married. The proportion of male participants who were college graduates or higher (20.2%) was significantly greater than that of females (16.5%; P < 0.0001), which was consistent with the patterns observed in those who attended middle and high school. For detailed information, please refer to Table 1.
Prevalence of Cigarette Smoking and Extent of ND
The smoking prevalence of participants was 66.1% [95% confidence interval (CI) 65.5%, 66.9%] for men and 3.2% (95% CI 3.0%, 3.8%) for women. For male smokers, the prevalence of current smoking (68.6%) was highest among those aged 45–54 years (95% CI 67.1%, 70.2%) and lowest among those aged 15–24 years (52.3%; 95% CI 49.4%, 55.2%; Table 2). For women, the smoking rate was the highest among those aged 65 years or older (11.5; 95% CI 7.92%; Figure 1).
Table 2. Prevalence of current smoking status and degree of nicotine dependence among Chinese male adults.
Among female smokers, the prevalence of H-ND was 0.31% (95% CI 0.13%, 0.49%), that of LM-ND was 1.01% (95% CI 0.68, 1.34%), and that of VL-ND was 1.66% (95% CI 1.24%, 2.07%). Thus, there was an increasing trend with rising years of age and those aged 65 years or older achieved the highest rates in the LM-ND and VL-ND subgroups (Figure 2A). For male smokers, 11.8% (95% CI 11.2%, 12.3%) were considered to be H-ND, 25.8% (95% CI 25.0%, 26.5%) were considered to be LM-ND, and 27.2% (95% CI 26.4%, 27.9%) were considered to be VL-ND (Table 2). Classified by age, the highest H-ND group was the group 45–54 years old (17.6%; 95% CI 16.3%, 18.8%), while the lowest H-ND group was that 15–24 years old (3.63%; 95% CI 2.54%, 4.72%). For LM-ND, those aged 55–64 years showed the highest percentage (32.5%; 95% CI 30.1%, 34.9%), and the lowest percentage was among those aged 15–24 years (16.4%, 95% CI 14.2%, 18.6%). VL-ND was reported most frequently among those aged 25–34 years (35.9%, 95% CI 34.2%, 37.6%). The prevalence of VL-ND decreased with increasing age, and the prevalence of H-ND was especially higher among those aged 65 years or older compared to other age groups (Figure 2B).
Figure 2. Nicotine dependence prevalence in (A) female and (B) male adults according to degree of nicotine dependence and age.
In terms of education (Table 2), the prevalence of smoking was the highest among males who attended only middle school (69.5%; 95% CI 68.3%, 70.7%) and lowest among those who were college graduates or more (59.6%; 95% CI 57.7%, 61.4%). H-ND was common among those who either attended elementary school or less (13.9%; 95% CI 12.3%, 15.5%) or only middle school (14.7%; 95% CI 13.7%, 15.7%); these two groups also demonstrated the lowest proportion of VL-ND (19.3%; 95% CI 17.4, 21.1, and 24.9%; 95% CI 23.7%, 26.0%, respectively). For the family income of male subjects (Table 2), those who earned at least Ұ 50,001 annually had the highest prevalence of smoking (69.4%; 95% CI 68.3%, 70.6%) and VL-ND (32.7%; 95% CI 31.5%, 33.8%), whereas this group had the lowest prevalence of H-ND (9.71%; 95% CI 8.98%, 10.4%). LM-ND was relatively evenly distributed across income categories.
For all male current smokers, an average of 14.5 ± 9.1 cigarettes was smoked each day (Table 3). Those aged 55–64 years smoked 19.9 ± 10.0 cigarettes per day (CPD). In the same age group, those who were H-ND smoked an average of 26.7 ± 12.4 CPD (Table S1 in Supplementary Material). As for all female current smokers, an average of 14.4 ± 7.9 cigarettes was smoked per day, and again, those 65 years of age or older had the highest average CPD (17.3 ± 8.1; Table 3).
Factors Associated with Smoking Initiation
Our data showed that 70.5% (95% CI 69.6%, 71.5%) of male smokers started to smoke daily at the age of 18–25 years (Table 4), whereas 67.0% (95% CI 58.0%–75.9%) of female smokers started at 26 years or older. Male smokers who first smoked at school or in the workplace had the highest proportion of continued smokers, 58.0% (95% CI 56.9%, 59.1%), in contrast to the 65.0% (95% CI 54.6%, 75.5%) of female smokers who first smoked at home. There was an estimated 81.9% (95% CI 81.1%, 82.8%) of male smokers and 64.0% (95% CI 54.6%, 73.4%) of female smokers who first smoked with their friends, whereas only 13.7% (95% CI 12.9%, 14.5%) of male smokers and 22.0% (95% CI 13.9%, 30.1%) of female smokers first smoked alone.
Social-environmental factors exerted vital effects on the initiation of smoking for both sexes (Table 5; Table S2 in Supplementary Material). Those whose parents smoked were more likely to smoke themselves [males: adjusted odds ratio (OR) 1.43; 95% CI 1.30, 1.57; P < 0.0001; females: adjusted OR 1.86; 95% CI 1.05, 3.31; P = 0.03]. The number of smokers who lived in the household probably conferred a greater risk of smoking for adults, especially for males (number of smokers living in the household ≥2; adjusted OR 1.58; 95% CI 1.40, 1.79; P < 0.0001). Also, the percent of friends who smoked was highly correlated with the risk of smoking. Compared with those for whom 25% or less of their friends smoked, those male or female individuals with approximately 100% smoker friends had about a fivefold higher risk of smoking (Table 5; Table S2 in Supplementary Material).
The Patterns of Smoking Cessation
Of the surveyed participants, only 2.9% were classified as former smokers (3.6% of men and no women) (Table 1). This indicates that very few smokers made any effort to quit or were successful at quitting. Among all male current smokers, those who had quit smoking at some time but were currently smoking accounted for 32.7% (Table 6). Of those who experienced smoking relapse, 90.1% did not receive any treatment or counseling on smoking cessation and only 9.9% quit smoking by using a nicotine patch, acupuncture, or other method. Similarly, the pattern of methods used to quit smoking was similar among male former smokers and female current smokers (Table 6).
Clinical Outcome Attributable to Cigarette Smoking
Under both univariate and multivariate models, logistic regression analyses were carried out to determine the adverse effect of smoking on respiratory and digestive symptoms. Smoking was significantly associated with all respiratory symptoms (adjusted OR 1.42; 95% CI 1.25, 1.61; P < 0.0001; Table 7). Cigarette smoking showed a significant association with cough (adjusted OR 1.48; 95% CI 1.29, 1.70; P < 0.0001), phlegm (adjusted OR 1.70; 95% CI 1.45, 1.99; P < 0.0001), chest pain (adjusted OR 1.55; 95% CI 1.02, 2.35; P = 0.04), nasosinusitis (adjusted OR 1.38; 95% CI 1.03, 1.88; P = 0.03), and chronic pharyngitis (adjusted OR 1.55; 95% CI 1.11, 2.15; P = 0.02). There also was evidence that cigarette smoking increased the risk of dyspnea (adjusted OR 1.52; 95% CI 0.98, 2.36; P = 0.06).
With respect to digestive symptoms (Table 8), we found a significant association of smoking with nausea (adjusted OR 1.43; 95% CI 1.12, 1.83; P = 0.005) and acid regurgitation (adjusted OR 1.30; 95% CI 1.08, 1.58; P = 0.007). Although it was not significant, there was a consistent trend of association of smoking with any symptom (adjusted OR 1.09; 95% CI 0.95, 1.25; P = 0.21), anorexia (adjusted OR 1.30; 95% CI 0.92, 1.84; P = 0.14), and stomach cold (adjusted OR 1.18; 95% CI 0.92, 1.51; P = 0.18). Together, our results show that current smoking might convey a higher risk of both respiratory and digestive symptoms.
In the present study, we provide further evidence of a high prevalence of smoking among Chinese male adults (66.1%) and a low prevalence in female adults (3.2%), which is in accordance with the findings from a recent study (3). Importantly, we first report the ND pattern in China based on a large-scale population. The average FTND score was 3.20 (95% CI 3.15, 3.25) among all Chinese male smokers, which is much higher than that in Chinese city residents (2.89; 95% CI 2.77, 3.01) (34) and slightly lower than that in Chinese rural–urban migrants (3.39; 95% CI 3.24, 3.54) (35). Of all male current smokers, 18.2% were categorized as H-ND and 39.8% were categorized as LM-ND; these smokers typically have considerable difficulty quitting tobacco without medical assistance.
The prevalence of LM-HD and H-ND was higher in old participants (>65 years) than in young ones, which is consistent with previous studies (34, 35). This indicates that psychological and pharmacological treatments should be focused on older smokers. The majority of young smokers were “social” smokers, with L-ND. Furthermore, male Chinese smokers who had low income or poor education were more likely to be H-ND, which concurs with the findings in smokers in other countries, including the USA (38, 39). In low- and middle-income countries, a 10% increase in the price can decrease the demand for cigarettes by 2–8% (40). This indicates that raising the tax on cigarette products will reduce the number of Chinese smokers who are not highly addicted to nicotine.
In the current study, most Chinese male smokers began regular smoking in early adult life. Previous study has documented that in China, approximately two-thirds of young men became cigarette smokers in their early adulthood and more than 6 million young men start smoking annually (3). Although the smoking rate of women is associated with older ages and remains low, it is necessary to maintain this low rate, which is increasing rapidly as the attitude of women toward smoking becomes more favorable (7, 41), as previously seen in central European and Latin American countries (42, 43). Young Chinese women are being targeted by the tobacco industry with the goal of increasing sales (7, 44), a technique that has been applied successfully in other countries (45). A recent meta-analysis showed that the prevalence of current smoking among adolescent Chinese women in 2006–2010 had increased 11.2-fold over 1981–1985 (46). Thus, the Chinese government not only needs to encourage the smoking cessation aggressively but also to protect non-smokers assiduously, especially adolescent and young adults, from smoking initiation (7, 8).
Our findings also demonstrated that social-environmental factors have an effect on initiation of tobacco smoking for both men and women in China. The smoking behaviors of parents, other family members, and friends were significantly associated with the initiation of smoking in the participants. Particularly, most of the male and female smokers were with their peers or friends when they first smoked. Individuals almost all of whose friends smoke had approximately a fivefold higher risk of smoking than those with very few friends who smoked, which is highly correlated with the cultural norms of China, where cigarettes are a requisite is part of a wide range of social events (6, 23).
Although there are a tremendous number of smokers in China, the quit rate is substantially lower than that in the developed countries, such as the UK and USA (6, 9, 10). A positive sign was that a growing number of Chinese smokers intended to quit in 2010 compared to 1996. However, it has been reported that the relapse rate increased from 12% in 1996 to 33% in 2010 (1, 9–11), which is similar to our findings in this study (32.7%). Most male and female smokers who experienced relapse did not use any method to assist with abstinence, and only a small portion of male and female smokers sought professional assistance in quitting. This indicates that offering effective cessation treatments will contribute greatly to a reduction in the prevalence of smoking. Furthermore, our results showed that current smoking remarkably increased the risk of respiratory and digestive symptoms. If nothing is done toward reducing or quitting smoking, these kinds of symptoms probably will develop into deleterious conditions (47, 48), which not only reduces the quality of life of patients themselves but also increases the burden on their families and, indeed, the whole society.
Although China signed the FCTC in 2003 and ratified it 2 years later, the Chinese government seems to be less effective in enforcing it (49). In many regions of China, smoking is still very prevalent; for example, people can smoke freely in a hospital, factory, school, or other public places (41, 49, 50). In addition, there is a very high prevalence of second-hand smoking in China because of relatively poor housing conditions, overcrowding, and poor ventilation systems (51). Data from the China Global Adult Tobacco Survey reported that approximately 740 million non-smokers suffered from second-hand smoking in 2010 (24). Urgently, firm actions should be taken on tobacco control issues. A successful model for China is in Hong Kong, a Special Administrative Region of China, which has sought to diminish the health burden of cigarette smoking for more than 20 years (52). Greater efforts are warranted to increase public awareness of the harmful consequences of cigarette smoking, raise taxes on tobacco products, restrain smoking in public places (e.g., school, work places, and restaurants), require large and graphic health warnings on cigarette packages, discourage social conventions that promote use (e.g., offering cigarettes to others), and establish effective smoking cessation treatments for those requiring assistance. All of these are necessary, as well as extending the medical insurance system to cover the cost of treatments.
Several limitations in this study warrant comments. First, the data used were based on self-report, which might lead to reporting inaccuracy, although it is commonly used in many population-based surveys, including tobacco research. Smoking by women is socially unacceptable in some countries, and in these places, estimates of the prevalence of smoking that depend on self-reporting might hide the true prevalence (9, 53). Second, we investigated the prevalence of smoking and ND in only two provinces of China (Zhejiang and Shanxi provinces), which might be not widely representative of the whole population of the country. However, the smoking pattern in these two provinces probably reflects that in many southern and northern provinces of China. In addition, this was a cross-sectional design-based survey, so temporal associations cannot be inferred. Large-scale longitude-based studies for surveying the pattern of ND in China are warranted.
In conclusion, this study was based on a large sample used to investigate the prevalence of cigarette smoking and the degree of ND in China. The prevalence of male smoking in the country is high, and a great number of smokers are highly dependent on nicotine, a group that has significant difficulties quitting without treatment. Chinese smokers with a considerable interest in cessation are impeded by ND and social-environmental factors. Our results will contribute to understanding the patterns of tobacco smoking in China and to defining the clinical implications for ND treatments. If the present course remains unchanged, in the near future, China will face a challenge of epidemic proportions caused by smoking.
This study was carried out in accordance with the recommendations of the Institutional Review Board guideline of the First Affiliated Hospital of Zhejiang University with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Institutional Review Board of the First Affiliated Hospital of Zhejiang University.
MDL, JW conceived the study and wrote the article. YM collected the data, performed the data analysis, and wrote the article. LW collected the data and performed the data analysis. WC, WY, ZY, KJ, XJ, MH, ZS, HH, KS, and SY collected the data. TJP wrote the article. All authors read the manuscript and approved.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
We thank Dr. David L. Bronson for excellent editing of this manuscript. This study was in part supported by Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine of Shanxi Agricultural University and research development fund from the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, and the Research Center for Air Pollution and Health of Zhejiang University.
The Supplementary Material for this article can be found online at http://www.frontiersin.org/article/10.3389/fpsyt.2017.00254/full#supplementary-material.
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Keywords: Chinese, nicotine dependence, smoking initiation, smoking cessation, respiratory and digestive symptoms
Citation: Ma Y, Wen L, Cui W, Yuan W, Yang Z, Jiang K, Jiang X, Huo M, Sun Z, Han H, Su K, Yang S, Payne TJ, Wang J and Li MD (2017) Prevalence of Cigarette Smoking and Nicotine Dependence in Men and Women Residing in Two Provinces in China. Front. Psychiatry 8:254. doi: 10.3389/fpsyt.2017.00254
Received: 23 July 2017; Accepted: 09 November 2017;
Published: 01 December 2017
Edited by:Marijn Lijffijt, Baylor College of Medicine, United States
Reviewed by:Siti Munira Yasin, Universiti Teknologi MARA, Malaysia
Robert F. Leeman, University of Florida, United States
Copyright: © 2017 Ma, Wen, Cui, Yuan, Yang, Jiang, Jiang, Huo, Sun, Han, Su, Yang, Payne, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.