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Front. Psychiatry | doi: 10.3389/fpsyt.2018.00052

Serum BDNF, and Plasma Catecholamine metabolites in Patients with Major Depressive Disorder: Preliminary Cross-sectional Study

  • 1University of Occupational and Environmental Health Japan, Japan
  • 2Department of Psychiatry, Fujita Health University, Japan

Background: There are complicated interactions between catecholaminergic neurons and brain-derived neurotrophic factor (BDNF) in the brain. However, no reports have addressed the relationship among 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and BDNF in the blood.
Objective: This paper sought to investigate correlations between serum BDNF and plasma levels of MHPG and HVA in major depressive disorder (MDD) patients.
Materials and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years old) who satisfied criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) were enrolled in the present study. Plasma levels of MHPG and HVA were analyzed using high-performance liquid chromatography, and serum BDNF was measured using ELISA.
Results: No interactions were observed between plasma HVA levels (mean±s.d.= 4.5±1.5ng/ml) and age(, sex, HAMD scores, or serum BDNF levels (mean±s.d.= 9.8±2.9ng/ml). No correlations were not also observed between plasma MHPG levels (mean±s.d.= 5.9±2.1ng/ml) and age, sex, the HAMD17 scores(mean±s.d.= 22.2±2.9ng/ml), or serum BDNF levels. Serum BDNF levels were negatively associated with HAMD17 scores.

Conclusion: The results suggest that there are no significant correlations between catecholamine metabolites and BDNF in the blood for MDD patients.

Keywords: catecholamine, Metabolites, Brain-Derived Neurotrophic Factor, major depression, Drug-naive

Received: 09 Dec 2017; Accepted: 06 Feb 2018.

Edited by:

Dr Brisa S. Fernandes, MD, PhD, Deakin University, Australia

Reviewed by:

Michele Fornaro, Columbia University, New York State Psychiatric Institute, United States
Serafim Carvalho, Cooperativa de Ensino Superior Politécnico e Universitário, Portugal  

Copyright: © 2018 Yoshimura, Kishi and Iwata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Reiji Yoshimura, University of Occupational and Environmental Health Japan, Kitakyushu, Japan, yoshi621@med.uoeh-u.ac.jp