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Mini Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2018.00621

Increased Risk of Metabolic Syndrome in Antidepressants Users: a Mini Review.

 Carla Gramaglia1, 2*,  Eleonora Gambaro1,  Giuseppe Bartolomei1, Paolo Camera1, Maira Chiarelli-Serra1,  Luca Lorenzini1 and  Patrizia Zeppegno1, 2
  • 1Scuola di Medicina, Università degli Studi del Piemonte Orientale, Italy
  • 2Azienda Ospedaliero Universitaria Maggiore della Carita, Italy

Mounting evidence has shown that the risk of metabolic syndrome (MetS) is substantially overlapping in the diagnostic subgroups of psychiatric disorders. While it is widely acknowledged that patients receiving antipsychotic medications are at higher risk of MetS than antipsychotic-naive ones, the association between antidepressants and MetS is still debated. The goal of our mini review was to analyze the relationship among depressive symptoms, antidepressant use and the occurrence of MetS. Adhering to PRISMA guidelines, we searched MEDLINE, reference lists and journals, using the following search string: ((("Mental Disorders"[Mesh]) AND "Metabolic Syndrome"[Mesh]) AND "Antidepressive Agents"[Mesh]), and retrieved 36 records. Two reviewers independently assessed records and the mini review eventually included the data extracted from 8 studies. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. Overall, the results of the mini review seem to support the association among depressive symptoms, antidepressants therapy and MetS. Except for H1-R high-affinity ones, the relationship between antidepressants and MetS still needs to be clarified. Considering the widespread prescription of antidepressants, both on behalf of psychiatrists and primary care physicians, further research on this topic is recommended.

Keywords: metabolic syndrome, Depression, antidepressant, cardiometabolic disease, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses

Received: 27 Jul 2018; Accepted: 02 Nov 2018.

Edited by:

Virginio Salvi, ASST Fatebenefratelli Sacco, Italy

Reviewed by:

Mirko Manchia, Università degli studi di Cagliari, Italy
Jess G. Fiedorowicz, University of Iowa, United States  

Copyright: © 2018 Gramaglia, Gambaro, Bartolomei, Camera, Chiarelli-Serra, Lorenzini and Zeppegno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Carla Gramaglia, Scuola di Medicina, Università degli Studi del Piemonte Orientale, Novara, 28100, Italy,