Impact Factor 2.857

Frontiers journals are at the top of citation and impact metrics

Systematic Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2018.00769

Antidepressant Effects of Repetitive Transcranial Magnetic Stimulation over Prefrontal Cortex of Parkinson’s Disease Patients with Depression: a Meta-Analysis

Liang Zhou1, 2, zhiwei Guo1, Guoqiang Xing1, 3, Haitao Peng1,  Mengjie Cai1, Huaping Chen1, Morgan A McClure1, Lin He1, Liangwen Xiong4, Bin He1, Fei Du5 and  Qiwen Mu1, 6*
  • 1Department of Radiology and Imaging Institute of Rehabilitation and Development of Brain Function, The Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Nanchong, China, 637000, North Sichuan Medical College, China
  • 2The Clinical Medical College of Southwest Medical University, Southwest Medical University, China
  • 3Johns Hopkins University, United States
  • 4University of Texas MD Anderson Cancer Center, United States
  • 5Harvard Medical School, United States
  • 6Peking University Third Hospital, China

Objective: The purpose of this meta-analysis was to investigate the anti-depression effects of repetitive transcranial magnetic stimulation (rTMS) over the prefrontal cortex (PFC) of patients with Parkinson’s disease (PD) and to determine the optimal rTMS parameters, such as the intensity, frequency and the delivered pattern of rTMS stimulation.
Methods: EMBASE, PubMed, Web of Science, MEDLINE, and Cochrane data bases were researched for papers published before March 12, 2018. Studies investigating the anti-depression effects of rTMS over PFC in patients with PD were considered. The main outcomes were depression scales scores such as Self-Rating Depression Scale (SDS), Hamilton Rating Scale for Depression (HAM-D), and Beck Depression Inventory (BDI). The mean effect size was estimated by calculating the standardized mean difference (SMD) with 95 % confidence interval (CI) by using fixed or random effect models as appropriate.
Results:Nine studies containing 137 PD patients with depression were included. The results showed significant anti-depression effect of rTMS over PFC in depressed PD patients (SMD = -0.55; p = 0.02). The subgroup analysis showed a better therapeutic effect of 5.0 Hz frequency rTMS (SMD = -0.90; p = 0.003) than that of less than 1.0 Hz frequency rTMS and greater than or equal to 10.0 Hz-frequency rTMS. Additionally, applied to supra-threshold of the rest motor threshold (RMT), rTMS produced significant anti-depressive effects (p < 0.0001, SMD = -0.82), whereas stimulation which used intensity of 90 % or 100 % of the RMT did not. Furthermore, rTMS treatment conducted in discontinuous days were more effective than those conducted in continuous days (SMD = -0.54; p = 0.03; vs SMD = -0.54; p = 0.11 respectively).
Conclusions: The results demonstrate significant anti-depressive effect of rTMS over PFC in PD patients with depression. 5 Hz rTMS with supra- threshold intensity conducted in discontinuous days might appear to be more effective than other treatment strategies. Future studies with larger number of participants are needed to validate the current findings and to expand the optimal rTMS protocols.

Keywords: Repetitive transcranial magnetic stimulation;, Prefrontal Cortex;, Parkinson’s disease;, Depression;, Meta-analysis

Received: 15 May 2018; Accepted: 21 Dec 2018.

Edited by:

Renerio Fraguas, University of São Paulo, Brazil

Reviewed by:

Jerome Brunelin, INSERM U1028 Centre de Recherche en Neurosciences de Lyon, France
Ivan V. Brak, State Scientific-Research Institute of Physiology & Basic Medicine, Russia  

Copyright: © 2018 Zhou, Guo, Xing, Peng, Cai, Chen, McClure, He, Xiong, He, Du and Mu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: MD, PhD. Qiwen Mu, North Sichuan Medical College, Department of Radiology and Imaging Institute of Rehabilitation and Development of Brain Function, The Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Nanchong, China, 637000, Nanchong, China,