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Case Report ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2019.00543

Antipsychotic-related hypothermia: Five new cases

  • 1Parnassia Psychiatric Institute, Netherlands
  • 2Leiden University, Netherlands
  • 3University of Groningen, Netherlands

Background: Hypothermia is a potentially fatal adverse effect of antipsychotic drug (APD) use. With only 69 cases described in the literature, the condition is considered rare.
Methods: We describe five new cases, in which we estimated the role of clozapine, haloperidol, olanzapine, penfluridol, risperidone, and zuclopentixol with the aid of two structured assessment tools.
Results: In addition to APD use, all five patients described by us had been exposed to one or more additional predisposing factors for hypothermia. Therefore, with the aid of the assessment tools, the causal role of APDs was considered ‘possible’ in four cases of moderate hypothermia, and ‘doubtful’ in the remaining one of mild hypothermia.
Conclusion: Although the best way to detect APD-related hypothermia is measuring the body temperature for a duration of at least 7-10 days after the start (or a dose increase) of APDs, the use of assessment tools to identify additional predisposing factors for hypothermia and establish their causal relationship with APD use would seem to be valuable for clinical decision-making (i.e., whether or not to discontinue APD use). Further research is needed to obtain reliable prevalence figures for APD-related hypothermia and its consequences, preferably in relation with physiological changes in body temperature.

Keywords: Body Temperature, Neuroleptic, Pharmacotherapy, psychosis, Schizophrenia, side effect, thermoregulation

Received: 01 Apr 2019; Accepted: 12 Jul 2019.

Edited by:

Paul Moser, Independent researcher

Reviewed by:

Anna M. Szota, Ludwik Rydygier College of Physicians, Nicolaus Copernicus University in Toruń, Poland
Yogaratnam Jegan, Consultant, Sri Lanka  

Copyright: © 2019 Zonnenberg, Bueno-de-Mesquita, Ramlal and Blom. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Jan Dirk Blom, Parnassia Psychiatric Institute, The Hague, 2553, Netherlands,