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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2019.00853

Shared response inhibition deficits but distinct error processing capacities between schizophrenia and obsessive−compulsive disorder patients revealed by event-related potentials and oscillations during a Stop signal task

 Fengqiong Yu1, Xingui Chen2, Lei Zhang1, Tongjian Bai2, Yaxiang Gao3, Yi Dong4, Yuejia Luo5, Chunyan Zhu1* and  Kai Wang2*
  • 1Anhui Medical University, China
  • 2First Affiliated Hospital of Anhui Medical University, China
  • 3Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Anhui Medical University, China
  • 4Anhui Mental Health Center, China
  • 5Shenzhen University, China

Background: Schizophrenia (SCH) patients are at high risk for obsessive−compulsive syndrome, which can lead to difficulty in differential diagnosis between SCH and obsessive−compulsive disorder (OCD). It would be of great clinical value to identify objective markers for these diseases based on behavioral or neurological manifestations. Deficient response inhibition has been reported in both SCH and OCD; however, it is unclear if common or distinct neural abnormalities underlie this impairment.
Methods: To address this question, we compared Stop signal task performance and associated event-related potentials (ERPs) and event-related oscillation (ERO) among 24 SCH patients, 25 OCD patients, and 27 healthy controls (HCs).
Results: In successful Stop trials, both SCH and OCD patients showed prolonged Stop signal response time, reduced ERP-P3 component amplitude, and weaker theta-band synchronization compared to HCs, while there were no significant differences between patient groups. In unsuccessful Stop trials, however, SCH patients demonstrated significantly lower P3 amplitudes and weaker theta-band activity than OCD patients. In addition, Stop accuracy rate in SCH patients was negatively correlated with Positive subscale score of the Positive and Negative Syndrome Scale.
Conclusions: These results provide evidence that impaired response inhibition in SCH and OCD arises from common underlying neural processing abnormalities. However, the lower P3 amplitude and weaker theta-band activity in SCH patients in unsuccessful Stop trials suggest distinct neural activity patterns related to error processing. These differences in ERPs and ERO may provide clues to unique neurological abnormalities in SCH and provide objective measures for differential diagnosis.

Keywords: Schizophrenia, Obsessive−compulsive disorder, response inhibition, error processing, N2, P3, theta oscillation

Received: 04 Aug 2019; Accepted: 30 Oct 2019.

Copyright: © 2019 Yu, Chen, Zhang, Bai, Gao, Dong, Luo, Zhu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Chunyan Zhu, Anhui Medical University, Hefei, China,
Prof. Kai Wang, First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China,