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Perspective ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2019.00876

An analysis of Cellular Communication Network (CCN) factor proteins as candidate mediators of postpartum psychosis risk

  • 1MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, United Kingdom

Postpartum (or puerperal) psychosis (PP) is a severe psychiatric condition associated with hallucinations, delusions, cognitive disorganisation and mood problems, which affects approximately 1-2 out of every 1000 new mothers shortly after childbirth. Whilst the risk factors for, and co-morbidities of, PP are relatively well-defined, currently the pathophysiology underlying the disorder is very poorly-specified. Here, I argue, on the basis of multiple lines of new evidence, that altered expression of the Cellular Communication Network (CCN) factor proteins (and of the heterodimerising CCN2 and CCN3 proteins in particular), may be associated with, and possibly causal for, increased PP risk. Future preclinical and clinical studies should aim to test this hypothesis as empirical support for it would provide much-needed clues regarding the biological substrates of PP, and could point to predictive biomarkers for the condition.

Keywords: Brain, Connective tissue growth factor (CTGF), Mood disorder, Myelination, nephroblastoma-overexpressed (NOV)

Received: 18 Jul 2019; Accepted: 06 Nov 2019.

Copyright: © 2019 Davies. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. William Davies, Cardiff University, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff, CF14 4XN, South Glamorgan, United Kingdom,