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CORRECTION article

Front. Psychiatry, 04 March 2021
Sec. Behavioral and Psychiatric Genetics
Volume 12 - 2021 | https://doi.org/10.3389/fpsyt.2021.642245

Corrigendum: Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder

This article is a correction to:

  1. Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder

    1. Read original article
\nJeffrey R. Bishop, Jeffrey R. Bishop1,2*Adam M. LeeAdam M. Lee1Lauren J. MillsLauren J. Mills3Paul D. Thuras,Paul D. Thuras2,4Seenae EumSeenae Eum1Doris ClancyDoris Clancy2Christopher R. Erbes,Christopher R. Erbes2,4Melissa A. Polusny,Melissa A. Polusny2,4Gregory J. Lamberty,Gregory J. Lamberty2,4Kelvin O. Lim,,Kelvin O. Lim2,4,5
  • 1Department of Experimental and Clinical Pharmacology, University of Minnesota College of Pharmacy, Minneapolis, MN, United States
  • 2Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, United States
  • 3University of Minnesota Supercomputing Institute, Minneapolis, MN, United States
  • 4Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, United States
  • 5Defense Veterans Brain Injury Center, Minneapolis, MN, United States

A Corrigendum on
Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder

by Bishop, J. R., Lee, A. M., Mills, L. J., Thuras, P. D., Eum, S., Clancy, D., et al. (2018). Front. Psychiatry 9:418. doi: 10.3389/fpsyt.2018.00418

In the original article, there was an error. We have identified four sentences where the words “increase” and “decrease” were mistakenly transposed. These four transpositions do not affect the integrity of the data and were the result of an error in translating the sign of the effect sizes from analyses to text. As a result of correcting these four transpositions, two sentences in the discussion contextualizing direction of change required modification.

A correction has been made to the Abstract sentences #9 and 11, the Results subsection FKBP5 Change from Before to after MBSR Treatment sentence #1, the Discussion subsection FKBP5 sentence paragraph 1sentence #1, paragraph 2 sentence #5, and paragraph 3 sentence #2.

Abstract sentence #9: There was a significant time x responder group interaction for methylation in FKBP5 intron 7 bin 2 [F(1, 19) = 7.492, p = 0.013] whereby responders had an increase in methylation and non-responders had a decrease in methylation from before to after treatment in this region.

Abstract sentence #11: Increases in FKBP5 methylation after treatment in responders as compared to decreases in non-responders suggest that effective meditation intervention may be associated with stress-related pathways at the molecular level.

Results>Methylation of FKBP5>Change from Before to after MBSR Treatment>sentence #1: There was a significant time x responder group interaction for methylation in FKBP5 intron 7 bin 2 [F(1, 19) = 7.492, p = 0.013, Bonferroni adjusted p = 0.052; Figure 4 and Supplemental Table 2] whereby responders had an increase in methylation and non-responders had a decrease in methylation from before to after treatment in this region. Discussion>FKBP5>sentence #1: Analyses of FKBP5 revealed increases in intron 7 methylation after treatment in responders while non-responders had decreases in methylation within a specific FKBP5 CpG site of bin 2.

Discussion>FKBP5>Paragraph #2>sentence #4: Additionally, consistent with our findings is that despite examining a different regulator region of FKBP5 than our study (exon 1 promoter vs. intron 7 GRE in our study) both of these investigations showed that changes in methylation were related to better symptom response with corresponding measures of increased gene expression identified in the study of PTSD response to exposure therapy (24).

Discussion>FKBP5>Paragraph #3>sentence #2: Collectively our findings as well as those of others are consistent with the hypothesis that non-pharmacologic interventions may facilitate stress reduction through the regulation of FKBP5 to feedback on glucocorticoid hyperactivity to reduce stress.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: PTSD, meditation, MBSR, treatment response, epigenetics, DNA methylation, FKBP5, SLC6A4

Citation: Bishop JR, Lee AM, Mills LJ, Thuras PD, Eum S, Clancy D, Erbes CR, Polusny MA, Lamberty GJ and Lim KO (2021) Corrigendum: Methylation of FKBP5 and SLC6A4 in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder. Front. Psychiatry 12:642245. doi: 10.3389/fpsyt.2021.642245

Received: 15 December 2020; Accepted: 08 February 2021;
Published: 04 March 2021.

Edited and reviewed by: Mehdi Pirooznia, National Heart, Lung, and Blood Institute (NHLBI), United States

Copyright © 2021 Bishop, Lee, Mills, Thuras, Eum, Clancy, Erbes, Polusny, Lamberty and Lim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Jeffrey R. Bishop, jrbishop@umn.edu

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