@ARTICLE{10.3389/fpsyt.2021.643315, AUTHOR={Preuss, Ulrich W. and Huestis, Marilyn A. and Schneider, Miriam and Hermann, Derik and Lutz, Beat and Hasan, Alkomiet and Kambeitz, Joseph and Wong, Jessica W. M. and Hoch, Eva}, TITLE={Cannabis Use and Car Crashes: A Review}, JOURNAL={Frontiers in Psychiatry}, VOLUME={12}, YEAR={2021}, URL={https://www.frontiersin.org/articles/10.3389/fpsyt.2021.643315}, DOI={10.3389/fpsyt.2021.643315}, ISSN={1664-0640}, ABSTRACT={In this review, state-of-the-art evidence on the relationship between cannabis use, traffic crash risks, and driving safety were analyzed. Systematic reviews, meta-analyses, and other relevant papers published within the last decade were systematically searched and synthesized. Findings show that meta-analyses and culpability studies consistently indicate a slightly but significantly increased risk of crashes after acute cannabis use. These risks vary across included study type, crash severity, and method of substance application and measurement. Some studies show a significant correlation between high THC blood concentrations and car crash risk. Most studies do not support this relationship at lower THC concentrations. However, no scientifically supported clear cut-off concentration can be derived from these results. Further research is needed to determine dose-response effects on driving skills combined with measures of neuropsychological functioning related to driving skills and crash risk.} }