ORIGINAL RESEARCH article
Sec. Psychological Therapy and Psychosomatics
Volume 12 - 2021 | https://doi.org/10.3389/fpsyt.2021.787822
Psychosocial and Motor Characteristics of Patients With Hypermobility
- 1SService of Physiotherapy, Fundação Faculdade Regional de Medicina de São José do Rio Preto, FUNFARME, São José do Rio Preto, São Paulo, Brazil
- 2Department of Neurological Sciences, Psychiatry and Medical Psychology, Faculdade de Medicina de São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil
- 3Graduated Student, Department of Neurological Sciences, Psychiatry and Medical Psychology, Faculdade de Medicina de São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil
- 4Service of Neurology, Santa Casa de Misericórdia de São Carlos, São Carlos, São Paulo, Brazil
- 5Department of Molecular Biology, Faculdade de Medicina de São José do Rio Preto - FAMERP, São José do Rio Preto, São Paulo, Brazil
Objectives: To identify psychosocial and motor aspects related to joint hypermobility (JH) in a sample from almost all Brazilian states by age range and sex; to characterize JH by the Beighton total score ≥4, ≥5, and ≥6 according to sex and age and atypicality in the sitting position and in the hands; identify, in the total sample, manifestations of “growing pain” and its location, fatigue, attention deficit, anxiety, insomnia, drowsiness, apathy, depression, delay in walking, not crawling or crawling differently, school performance, spatial orientation and/or temporally impaired, social isolation, and being stigmatized as “lazy/clumsy/apathetic”.
Methods: This retrospective, observational, quantitative, and cross-sectional study used data obtained through analyses of descriptive and inferential crossings between 2012 and 2020 of 482 medical records of individuals between 1 and 76 years of age, from most Brazilian states. All patients previously diagnosed with “joint hypermobility syndrome” (JHS) and “Ehlers-Danlos syndrome hypermobility type” (EDS-HT) had their medical records reassessed, following the guidelines established in 2017. The analysis of GJH was performed using the updated method by Beighton method; atypical characteristics were investigated in the hands and the ability to sit in the “W” and the “concave” positions. The characteristics and manifestations of “growing pain” and its location were analyzed in the total sample, fatigue, insomnia, drowsiness, apathy, depression, social isolation, attention deficit, anxiety, stigmatization as “lazy,” clumsy/restless, impaired school performance, and spatial and/or temporal orientation. Descriptive and inferential statistical methods were used, such as Mean, Median, Mode, Standard Deviation, Standard Error, Maximum Value, Minimum Value, Komolgorov-Smirnov, Significance, Relative Value, Absolute Value, Mann-Whitney U, and Correlation of Spearman.
Results: JH in the total sample predominated in the upper limbs, the majority were women, represented by 352 (73.02%), 15 years old or older with 322 (66.80%), 312 (64.73%) had a Beighton total score ≥6, which decreased as the age increased. Always sitting in the “concave” position was represented by 54.15% and the ability to sit in the “W” position by 39.21%; signs on the hands totaled between 27.59 and 44.19% with a significant correlation between the variables. Among the characteristics, fatigue predominated, followed by an awkward/clumsy/restless individual, attention deficit, anxiety and stigmatized as “lazy,” insomnia, drowsiness, apathy, depression, impaired spatial and/or temporal orientation, and social isolation. From the total sample, pain in the lower limbs was reported by 55.81% and having or having had “growing pain” was reported by 36.93%, delay in walking occurred in 19.92%, 15.35% did not crawl or crawled differently, and for 12.86%, school performance was impaired. Higher Beighton total scores showed a trend towards motor implications and correlation between variables. Ability to still sit in the “concave” position was possible for 54.15% and to sit in the “W” position for 39.21%.
Conclusion: In the total sample, the JH characteristic prevails in the upper limbs of female children, adolescents and adults, with a total Beighton score ≥6. Most sit in the “concave” position and less than half also sit in the “W” position and with atypical hand postures. The higher Beighton scores, which include the upper limbs, show a tendency to not crawl or crawl differently, delayed ambulation, and impaired school performance. The predominance of JH in the upper limbs is suggestive of a justification for not crawling or crawling differently. Characteristics of atypical motor performance in hands and sitting posture, in addition to fatigue, pain since childhood, anxiety, apathy, depression, sleep disorders, stigmatization, attention deficit, spatial and/or temporal orientation impairment, and social isolation are characteristics. suggestive of psychosocial implications at different ages. Future studies with motor and psychosocial aspects of people with JH will help to identify the phenotype of this population and consequent guidance for clinical management based on the motor and psychosocial aspects of people with JH.
Joint hypermobility (JH) may represent the extreme normal range of the motion spectrum or condition for a group of hereditary connective tissue disorders, which is influenced by age, sex, and ethnicity (1). It has a Gaussian distribution on the spectrum of physiological range of motion and is considered a genetically determined deviation from normality (2). It can be a descriptor and exist as an isolated diagnostic finding, but it is often a feature of a larger syndromic diagnosis, rarely diagnosed (3), and considered by most professionals as a harmless ability (4).
The method for JH assessment was proposed by Beighton et al. (5). In 2017, an International Consortium for the Ehlers-Danlos Syndromes (EDS) proposed the 2017 International Classification for EDS and recognized 13 subtypes of EDS (2). Among the 13 subtypes, the hypermobile EDS subtype is similar to the hypermobility spectrum disorders (HSD), an underrecognized group of connective tissue disorders that involves a spectrum ranging from asymptomatic hypermobility, or hypermobility affecting only one joint, to generalized joint hypermobility (GJH) (6). This new classification included the Beighton method among its diagnostic criteria, with adjustments, and considerations that included changes in the parameters of the scores. The score ≥6 is for prepubertal children and adolescents, a score ≥5 is for pubertal men and women up to 50 years of age, and a score ≥4 is for those over 50 years of age (2). In the same year, Castori et al. (6) proposed a criteria for identification of the characteristics.
The diagnosis for hypermobile Ehlers-Danlos syndrome (hEDS) is clinical and considers the presence of criteria (6, 7) including a spectrum of phenotypes, ranging from asymptomatic condition, non-syndromic JH, to hEDS, and HSD. In 2019, Copetti et al. (8) explored the clinical ramifications of hEDS and HSD and grouped these conditions into a single phenotype termed hEDS/HSD and considered severity in class distinction. HSD has become updated diagnostics for all those individuals who were diagnosed by previous criteria as hEDS-HSD or joint hypermobility syndrome (JHS). HSD is also intended to identify milder subtypes that fill the entire gap between asymptomatic JH and hEDS (6).
GJH is relatively common, with a prevalence of 2–64.6% in different populations, varying among age, sex, and ethnicity of the population (9–11). It is common in childhood, affecting ~8–39% of school-age children (12), 41% of children and adolescents (13), and 64.6% of pre-school-age children (9). It is more frequent among women and children and among Asians, followed by African-Americans and Caucasians (14–16). However, the locomotor system of the child with JH, already in the first year of life, may present characteristics that signal implications in neuropsychomotor development (17–19). Signs may include motor and cognitive deficits, benign motor delay (20), frequent falls (21–24), “flying bird” hand sign, Steinberg sign, and Walker-Murdoch sign (19, 25–27).
Individuals with JH are more vulnerable to microtraumas (28–30) and macrotraumas (31), and eventually adopt inadequate postural habits (32–34) because of their less robust tissues, which imply insufficient support of the physiological function of the locomotor apparatus. It is relevant that tissues can suffer degenerative processes (35), with insidious and silent signs and symptoms (36). This pattern of joint involvement results in several well-defined physical factors and implications in other characteristics resulting from inadequate postures (37).
In addition to motor characteristics, psychological dysfunctions and emotional problems, including depression, anxiety, affective disorder, low self-confidence, negative thoughts, hopelessness, and despair, are common among these patients (38–41).
Psychosocial Disorders Related to Hypermobility
Psychological dysfunctions and emotional problems are common among those with EDS and may have consequences for ignoring or not confronting the presence of comorbid psychological problems, which may lead to suboptimal treatment (42). However, there is a growing amount of evidence pointing to a high prevalence of psychiatric conditions among individuals with EDS (41), which includes, among others, anxiety disorders, depression, and neurodevelopmental disorders, such as attention deficit hyperactivity disorder, and other clinical manifestations, associated with JH (43, 44).
Difficulties in the acquisition and performance of motor skills results in categorization of this population as clumsy, stubborn, and with clumsy handwriting, poor postural control, and difficulties in motor learning. Study by Vaivre-Douret (45) corroborates these results, pointing out that children with developmental coordination disorders are characterized by difficulties in the acquisition and performance of motor skills, which persist into adolescence and adulthood.
A previous study reports signs of malaise in these patients, lack of concentration and memory, low self-efficacy and self-worth, and anxiety and depression (46). Depressive feelings are common in hEDS and can be understood as secondary to the difficulties related to the disease (47). Patients with hEDS often suffer from anxiety disorders, and the link between these two variables has been repeatedly found in the literature (48, 49). In 2021, De Vries et al. (50) showed that adolescents and young adults with a combination of GJH and anxiety were significantly impaired, with decreased physical and psychosocial functioning, decreased workload, increased fatigue, and debilitating pain (50).
Fatigue is also present in most affected individuals, manifesting as persistent feelings of tiredness, lack of energy, and feelings of exhaustion with impaired concentration (51). Bravo (26) found symptoms of chronic fatigue, dizziness, and fainting in 40% of men and 64% of women <30 years of age, a condition that receives little medical attention (52).
In general, people with EDS report how they must deal with the social image that people around them have about them. They are labeled as lazy, apathetic, and tired people who are unable to accomplish a project, when in fact they are too exhausted to do it (53). In addition, because of the invisible nature of this disease, they face judgments from friends, family members, and strangers (54). Thus, some patients exhibit an excessive rest pattern. Therefore, they are labeled hyperactive or lazy, or still as unsociable, and depressed (47). Shame, guilt, and stigma may have negative psychosocial consequences, decrease self-esteem, and lead to depression (54) and feelings of social isolation (55).
Nocturnal insomnia and morning sleepiness are frequent in hEDS (56–58). Patients with hEDS report sleeping problems, including insomnia and non-restorative sleep (14, 59). Baeza-Velasco et al. (39) cite that reduced sleep is related to pain complaints, with psychosocial consequences and chronicity for the quality of life. The presence of “growing pain” in children was reported by Matsudo et al. (60), who identified that in most cases pain occurred in the lower limbs. Early recognition and adequate treatment of problems such as sleep function, mobility, chronic pain, and psychological conditions are important for successful holistic treatment of patients with EDS (61).
To identify psychosocial and motor aspects related to JH in a sample from almost all Brazilian states by age range and sex; to characterize JH by the Beighton total score ≥4, ≥5, and ≥6 according to sex and age and atypicality in the sitting position and in the hands; identify, in the total sample, manifestations of “growing pain” and its location, fatigue, attention deficit, anxiety, insomnia, drowsiness, apathy, depression, delay in ambulation, not crawling or crawling differently, school performance, spatial orientation and/or temporally impaired, social isolation, and being stigmatized as “lazy/clumsy/apathetic.”
According to the Regulatory Standards for Research in Human Beings, Resolution 466/2012 of the National Health Council, this study was approved by the Research Ethics Committee (CEP) of the São José do Rio Preto Medical School (FAMERP), Opinion CAAE No. 36145820.6.000.5415. Data collection was performed after approval of the waiver for the need of the Informed Consent Form.
This is a retrospective, observational, quantitative, and cross-sectional study. Clinical records of patients with JH, seen at the Clínica de Fisioterapia Lamari Ltda of São José do Rio Preto—SP, were analyzed. Inclusion criteria were adopted for medical records that contained the data listed in the data collection instrument.
This study was conducted after the publication of the new nosology for EDS and disorders associated with hypermobility in 2017 (2), which considers specific clinical presentations for EDS subtypes and introduces the concept of hypermobility spectrum (6). Therefore, all patients previously characterized or diagnosed with JHS/EDS-HT, according to the previous nosology and criteria, had their records reevaluated, following the guidelines established by the new nosology for EDS.
The records were made in an instrument with a specific questionnaire for the analysis of the characteristics of joint hypermobility (JH) and related clinical features. The data were tabulated in an excel spreadsheet, prepared as the recording tool for the study.
The results were obtained from the analyses by descriptive and inferential crossings of the data from the sample of 482 medical records of individuals seen in the period from 2012 to 2020, from 21 Brazilian states and the Federal District, totaling 124 cities. The group consisted of individuals with age group between 1 and 76 years, with a mean age of 25 years (SD = 15.94). Of these, 322 (66.80%) were aged ≥15 years, and 352 (73.02%) were women. The absolute and percentage distribution of the total sample by age-group and sex is shown in Table 1.
The family history of JH was reported by 382 (79.25%), and others were unaware of any history. The total sample consisted of 427 (88.5%) individuals with HDS and 55 (11.4%) with hEDS.
Data Collection Tools
Data collection was made by the researcher using a self-developed instrument from March 2020 to July 2020, to record the data obtained from the medical records of the patients seen at the Clínica de Fisioterapia Lamari Ltda of São José do Rio Preto in the period from January 2012 to March 2020. The data from the clinical history, general and specific physical examination, characteristics associated with JH, analysis by the Beighton method (5), considering the new classification criteria (2, 6), and the family history of JH were included.
Analysis of GJH by the Beighton Method
Joint mobility was evaluated in the joints of five body regions: fifth finger, wrist, elbow, knee, and trunk, using the method proposed by Beighton et al. (5).
The Beighton total score consists of five variables, of which four are tested bilaterally and one test evaluates the lower back and lower extremities. For scoring, the following variables were considered: thumb apposition, fifth finger extension, elbow extension, knee extension, and “complete anterior flexion of the trunk with flat hands on the floor, with extended knees” (AFT). Total scores ranged from 0 to 9. Joint mobility was evaluated according to the scores proposed by Beighton et al. (5). One point was scored for each positive result (for each side), and a total score was attributed by adding up the variables. The correlation and significance between each of the Beighton scores ≥4, ≥5, and ≥6 were analyzed, according to sex and age range.
Analysis of Hip and Trunk JH
The JH of the hip and trunk was evaluated using sitting positions on the ground and was defined as present when the following were observed: sitting in the “W” position with the lower limbs abducted, and with the knees in full flexion and the feet lateralized, sitting in a “concave” position, that is, trunk and head anteriorized, with protruding shoulders and abdomen. The variables sitting in “W” and “concave” positions were analyzed by “age range” and in the total sample, considering those who were never able to sit in these positions, as well as those who were always able to sit in these positions and those who had been able to sit in these positions only in the past. The illustrations are shown in Figure 1. The significance of these variables was analyzed, considering age groups, as well as in the total sample. The data are presented in Table 5.
Analysis of JH Features on the Hands
JH in the hands was defined as present when the related abilities were identified. The “birds flying” hand sign was evaluated by the active hyperextension of the fingers. The JH was defined as present when the angle of the metacarpophalangeal joints was greater than 20° in both hands. The “greeting” sign was evaluated considering the act of shaking hands when greeting. JH was defined by the perception of excessive hand mobility, as well as the sensation of softness of the skin while shaking hands during the act of greeting. Writing adaptation was evaluated during the act of writing. JH was defined as present when the patient held the pencil or pen in an atypical way, that is, not consistent with support by the pinch movement of the thumb and index fingers. The correlation and significance between these variables were analyzed. The illustrations are shown in Figure 2.
Figure 2. Illustration of the flying bird hand (A), greeting sign (B), and adaptation for writing (C).
Descriptive and inferential statistical methods were used. Probability issues of a population were analyzed based on the sample data, for which mean, median, mode, standard deviation, standard error, maximum value, minimum value, Komolgorov-Smirnov test, significance, relative value, absolute value, Mann-Whitney U test, and Spearman correlation test. Hypothesis tests were performed using Mann-Whitney's U test and Spearman's correlation test to analyze the behavior of correlations between the variables analyzed and the degree of explanation of the dependent variable in relation to the independent variables of the sample. The data were replicated in absolute and relative forms in this first part. In the inferential scope, it was outlined as a statistical objective, and the analysis of independence and prediction between the variables was proposed in the scope of work. The results of independence between the proposed variables were given by analysis between the values of p (significance). All analyses were conducted using the SPSS Statistics Software (version 23) linked to the features of the Excel tool (version 2.016).
Characteristic of JH by Beighton Total Score, Sex, and Age in the Total Sample
Analyses of the total sample by Beighton scores, which scores and characterizes JH currently in five regions of the body, with a score variation of 0–9, showed that the mean was represented by score 6 (SD = 2.12). Analyses of the total sample by the Beighton scores, which scores and characterizes JH currently in five body regions, with a score range from 0 to 9, showed that the mean was represented by a score of 6 (SD = 2.12). Analyses of the distribution of the total Beighton scores in the total sample showed that the total Beighton score ≥4 was completed by 426 (88.38%), the score ≥5 by 344 (71.37%), and the score ≥6 by 312 (64.73%). The score ≤3 was filled by 56 (11.64%).
The Komolgorov-Smirnov Normality and Spearman Correlation statistical tests were applied, which pointed out that the total Beighton scores as a function of sex and age in the total sample show a non-significant tendency for women to obtain higher Beighton score scores (rs = −0.050, p = 0.259). Smaller stature and younger age show a tendency for higher total Beighton scores, with a statistically significant difference (rs = −0.161, p = 0.000; rs = −0.216, p = 0.000).
Beighton Scores ≥4, ≥5, and ≥6 by Sex and Age Group in the Total Sample
Analyses of the distribution of Beighton's total scores ≥4, ≥5, and ≥6 in the total sample as a function of sex are presented in Table 2, where the correlations between each of the scores ≥4, ≥5, and ≥6 with sex and their respective “p” values are shown. In Table 3, correlations between each of the scores ≥4, ≥5, and ≥6 with age group and their respective “p” values are shown.
Table 2. Absolute and percentage distribution of Beighton scores ≥4, ≥5, and ≥6 by gender in the total sample.
Table 3. Absolute and percentage distribution of Beighton scores ≥4, ≥5, and ≥6 by age-group and in the total sample.
General Physical Characteristics of JH in the Locomotor Apparatus in the Total Sample
Analyses of physical characteristics in the locomotor apparatus showed that a minimum of 133 (27.59%) and a maximum of 213 (44.19%) individuals presented different physical signs in the hands, and 261 (54.15%) participants were sitting always in the “concave” position. A majority of 337 (69.92%) participants reported that they were able to “sit in a concave position,” including those who were able to do so in the past. Sitting in the “W” position was always possible for 189 (39.21%), and when we included those who were able to do so in the past, they comprised a majority of (55.81%) of the total sample.
Physical Signs of JH on the Hands in the Total Sample
Among the characteristics of physical signs on hands, the sign “flying bird hands” comprised 213 (44.19%) individuals, “compliance” sign, 189 (39.21%), writing adaptation, 161 (33.40%), weak hands for handling, 157 (32.57%), and tiredness due to writing, 133 (27.59%).
Analyses were performed to verify a correlation between the total Beighton score, “birds flying” sign, and the “compliance” sign in the total sample. Analyses of the “compliance” sign variable showed positive and significant correlations between the Beighton score and the “compliance” sign variable (rs = 0.167; p = 0.000), as well as with the “bird hands flying” variable (rs = 0.150; p = 0.001). Thus, the presence of the “greeting” sign and/or “flying bird hands” correlated with the Beighton scores for GJH.
Analyses to verify the correlation between the variables referring to the clinical signs of the hands are presented in Table 4.
Body Postures and Skills Never Presented, Always Presented, Presented Only in the Past, by Age-Group and in the Total Sample
The analyses show that sit “concave” was always possible for 261 (54.15%) individuals of the total sample. When also considering those who were able to do so in the past, they represented the majority with 337 (69.92%), as the difference was not significant in the total sample (p = 0.556) and by age-group (p = 0.502). The ability to sit in a “W” posture was always possible for 189 (39.21%) of the total sample. When also considering those who were able to sit in a “W” posture in the past, they represented the majority with 269 (55.81%) of the total sample, with difference not significant in the total sample (p = 0.429) and in the age-group (p = 0.284). The absolute and percentage frequencies of body postures and skills in the age-groups never presented, always presented, and presented only in the past by age-group and in the total sample and p values of the variables in the age-groups and in the total sample are presented in Table 5.
Table 5. Absolute and percentage frequencies of body postures and skills never presented, always presented, and presented only in the past by age-group and in the total sample and p values.
Psychosocial Characteristics in the Total Sample
Among the characteristics of psychosocial implications, fatigue accounted for more than half of the total sample. Clumsy, stubborn, or apathy individuals and individuals with attention deficit accounted for slightly less than half of the total sample. Anxiety, having been stigmatized as “lazy,” insomnia, sleepiness, social isolation, apathy, depression, and impaired spatial and/or temporal orientation comprised 15.76–28.01% of the participants. An analysis of the total sample referring to pain in the lower limbs as a symptom was reported by the majority and “growing pain” by more than one third of the total sample. The absolute values and percentages are presented in Table 6.
Analyses to verify in the total sample if there is a correlation between the total Beighton score and “growing pain” to show that the more the total Beighton score increases, there is a tendency not to have “growing pain,” and the difference was not significant (p = 0.827), according to Spearman's test (rs = −0.010).
Aspects Related to Neuropsychomotor Development
Analysis of characteristics related to neuropsychomotor development showed that 19.92% showed delayed walking, 15.35% did not crawl or crawled differently, and school performance was impaired for 12.86%. Variables related to motor performance show that for higher total Beighton scores, there is a tendency for motor implications and correlation between the variables. Analyses to verify whether there was a correlation between total Beighton scores and having crawled differently show that as the total Beighton score increased, there was a greater tendency to crawl differently; however, the difference was non-significant (p = 0.548), according to the Spearman's test (rs = 0.027).
Analysis also showed that the higher the total Beighton score, the greater the tendency not to crawl, with the difference being non-significant (p = 0.954), according to the Spearman test (corr = −0.003). For those who crawl differently, there was a tendency to have impaired school performance, and the difference was significant (p = 0.036), according to the Spearman's test (Corr = 0.095); for those who crawl differently, there was a tendency to have delayed ambulation, and the difference was not significant (p = 0.190), according to Spearman's test (Corr = 0.060). Participants who did not crawl showed a tendency to have impaired school performance, with a non-significant difference (p = 0.064), according to Spearman's test (Corr = 0.084); those who did not crawl showed a tendency for delayed walking, with significant difference (p = 0.003), according to Spearman's test (Corr = 0.136), and for those whose school performance was impaired, there was a tendency for delayed walking, with significant difference (p = 0.014), according to Spearman's test (Corr = 0.112). The values are presented in Table 7.
Table 7. Correlation analysis between motor performance variables, Beighton score, impaired school performance, and motor performance variables.
Although the process of joint movement in the human species is complex, with few references to normality standards, JH seems to sensitize scholars, which can be verified by the large number of publications on the subject found in the specialized literature and with emphasis on conditions related to JH. Analyses of this study included both genders and the different age-groups including participants from almost all the Brazilian states and the Federal District and show that the characteristic of JH predominates in the upper limbs, decreases with increasing age, with most children, adolescents, and adults having a total Beighton score ≥6. However, this reference score ≥6 was proposed by the new nosology (2) only for prepubertal children and adolescents.
In this context, the prevalence of JH in the upper limbs in the total sample, predominant signs in the hands, verification of significant correlations between total Beighton score, “flying bird hands” sign, “compliance” sign, adaptation for writing, weak hands for handling, and tiredness due to writing must be considered. These characteristics in the hands, among others, such as Steinberg's sign and Walker-Murdoch's sign (25), can justify inadequate neuropsychomotor development, with motor and cognitive deficits, benign motor delay (20), and frequent falls (21–24). The “flying bird hands” sign was cited by Lamari et al. (19) and Bravo (26).
It is also emphasized by the fact that most of the individuals in the present study are capable of always sitting in the “concave” position, due to weakness, mainly, of the abdominal and paravertebral muscles. When considering this capacity only, in the past, they totaled 69.92% of the total sample. The ability to sit in the “W” position also stands out, because of hypermobility of the hips, which has always been possible for a little less than half of the total sample, and when considering also those who in the past were capable of sitting in the “W” position, they represented the majority of the total sample.
All these findings together may contribute and corroborate to explain the fact that part of this study population is not able to crawl or has crawled differently, as well as the delay in ambulation and the presence of fatigue since the beginning of neuropsychomotor development. These conditions may, in part, explain the psychosocial implications, such as anxiety, stigmatization as “lazy,” sleep disorders, apathy, impaired spatial and/or temporal orientation, depression, and finally, social isolation. The composition of the tissues of the locomotor system, along with the insufficient condition of its biomechanics, is suggestive of insufficiency for the daily demands.
It is essential to identify this population from childhood, because the locomotor system of the child with JH may present clinical signs in the first year of life (17–19). In 2005, a study with 1,120 Brazilian children aged 4–7 years of both sexes was carried out to identify hypermobile children (9). It was found that most preschool children obtained a Beighton score ≥4 (64.6%), score ≥5 by 38.2%, and ≥6 by 27% of them. The study concluded that the parameter related to score ≥4 was used for children and that other parameters should be differentiated for children. Further, inclusion of many studies could have compromised results because they included different ages in the same sample and analyzed by the same criteria and parameters. In 2017, an International Consortium for EDS proposed the 2017 International Classification for EDS and recognized 13 subtypes of EDS with secondary diagnostic criteria described for each subtype (2). Among the 13 subtypes, there is the subtype hypermobile EDS, similar to HSD, an underrecognized group of connective tissue diseases that involves a spectrum ranging from asymptomatic hypermobility or hypermobility affecting only one joint to GJH.
Another study by Yazgan et al. (62) with children investigated the prevalence and characteristics of JH in prepuberty with JH defined using the Beighton criteria. The prevalence of the characteristics with scores ≥4 was 39.3%, ≥5 with 22.7%, and ≥6 with 13.3%. The difference in the age-groups between the study populations of Lamari et al. (9) and of Yazgan et al. (62) may have accounted for the significant reduction in the presence of the JH traits that corroborate the process of tissue maturity with a decrease in joint mobility and definition of the hypermobile population even in childhood.
Morris et al. (63) analyzed JH in a cohort study of 1,584 Australian adolescents using the Beighton scoring system. The prevalence of AGH was 60.6% and 36.7% among girls and boys, respectively, considering the Beighton score ≥4; when defined as ≥6, it was 26.1 and 11.5%. The high prevalence rates of GJH as defined by the commonly used Beighton cut-off values in this cohort highlight the need to question the appropriateness of these cut-off points in future studies and be powered for sex-specific analyses due to the different prevalence rates of JH in male and female samples.
Analyses of the present study corroborate the literature on the effects of biological aging of the tissues that contribute to diminishing the JH and conceal joints affected by JH. The effect of age can negatively impact the range of motion of the joint, which has led some researchers to hypothesize the occurrence of chronic musculoskeletal symptoms in adults who progressively lose the JH. The five-point questionnaire was introduced as a rapid screening tool to investigate historical JH in adults who presumably lost GJH (64). Castori et al. (65) supported this hypothesis. This questionnaire is simple and a reproducible self-report that can be used as an adjunct in the clinical evaluation of chronic and diffuse pain syndromes where JH is often missed, as well as for individuals who have progressively lost GJH. However, it does not nominally include the characteristics observed in clinical practice, which would facilitate their historical identification, a condition that would adequate the targeted treatment. In this context, the present study investigated the physical characteristics both nominally and individually. It was observed that majority of the study sample sat concave or in the “W” position. These postures and body skills are frequent in just under half or more than half of the different age-groups. They are antifunctional and anti-aesthetic postures and can compromise the conformation of the joints and consequently the mechanics of the locomotor system and facilitate falls.
Hershenfeld et al. (41) identified psychosocial impairment in hypermobile individuals, and Tinkle et al. (42) pointed out psychological dysfunction and emotional problems as common among those with EDS, which can lead to avoidance behavior, exacerbation of dysfunction and disability, marginalization, resentment, distrust and hostility between patient, family, and health team. Being ignored, disrespected, and receiving a psychological and/or psychiatric explanation may have consequences for ignoring or not confronting the presence of comorbid psychological problems, resulting in suboptimal treatment. In the same year, Bulbena et al. (48) concluded that there is a growing amount of evidence pointing to the high prevalence of psychiatric conditions among individuals with hEDS.
Other authors have also demonstrated a high prevalence of anxiety disorders, with panic disorder and simple phobia (44, 66). It is evident that anxiety disorders, depression, and neurological development disorders such as attention deficit hyperactivity are, among other clinical manifestations, associated with JH (43, 44).
In this study, among the psychosocial characteristics, fatigue accounted for more than half of the total sample. Clumsy, stubborn, or restless individuals and with attention deficit accounted for just under half of the total sample. Anxiety, stigmatized as “lazy,” insomnia, sleepiness, social isolation, apathy, depression, and impaired spatial and/or temporal orientation represented a minimum of 15.76% and a maximum of 28.01%. In this context, fatigue in hEDS is considered multifactorial (17, 67, 68). It is present in most affected individuals, manifesting with a persistent feeling of tiredness, lack of energy, and feeling of exhaustion, with impaired concentration (51). Increased rates of celiac disease were identified in hEDS, suggesting intestinal malabsorption as a possible factor for fatigue (51, 69). Results of this study on fatigue corroborate the literature, and Bravo (26) found symptoms of chronic fatigue, dizziness, and fainting in 40% of men and 64% of women under 30 years of age. The manifestation of fatigue and musculoskeletal pain, in general, receives little medical attention (52).
Recent studies show manifestation of malaise, lack of concentration and memory, and low self-esteem and self-worth, with a change in the role in society, anxiety, and depression (46), and providing evidence for a longitudinal association between JH and depression at 18 years of age (70). Depressive feelings are common in hEDS and can be understood as secondary to disease-related difficulties such as pain, disability, frustration with the medical system, living a restricted life, etc. (47).
Patients with hEDS often suffer from anxiety disorder, and the link between these two variables has been repeatedly found in the literature (48). It is also associated with a higher frequency and intensity of fears, a higher anxiety severity, greater somatic complaints, and a higher frequency of the so-called endogenous anxiety disorders (49). In 2021, De Vries et al. showed that adolescents and young adults with combined GJH and anxiety were significantly impaired, showing decreased physical and psychosocial functioning with a decreased workload, increased fatigue, and disabling pain. This study confirms the association between GJH and anxiety (50).
In general, people who suffer from EDS report how they must deal with the social image that people around them have, because although they look normal, they have many restrictions that limit their daily routines. Thus, they are labeled lazy, apathetic, and tired people who cannot accomplish tasks, when in fact they are too exhausted to do so (53). In a current qualitative study, participants described internalized negative feelings about their own bodies. They described themselves as “weird” or “useless,” feeling shame and guilt. They found difficulty in keeping up and maintaining contact with friends and family, which generated feelings of frustration and anger among participants, as their joints did not always support their desires. In addition, due to the invisible nature of this disease, they faced judgments from friends, family, and strangers (54).
The transition from the lying to orthostatic position can lead to a state of physical discomfort, with dizziness and fainting, among others, due to lack of oxygen to the brain. Thus, some patients present an excessive resting pattern. Therefore, patients with EDS are often labeled as hyperactive or lazy or still as unsociable and depressed (71).
Shame, guilt, and stigma can have negative psychosocial consequences, decreases self-esteem, and may lead to depression (54). There is anecdotal evidence that symptoms can be triggered by an event, which then has long-term consequences, eventually leading to feelings of isolation (55).
Patients with hEDS report sleeping problems, including insomnia and non-restorative sleep (14, 59). Several factors can interfere with sleep in this population, including pain, dysautonomia, and use of medications (72). Baeza-Velasco et al. (39) cited that reduced sleep is related to the complaint of pain, with psychosocial consequences and chronicity for the quality of life. This study showed that 26 (43.9%) individuals of the total sample reported some sleep disorder. Of these, 16 (28.1%), represented by the majority, reported sleepiness, seven others (12.3%) insomnia, and two (3.5%) daytime sleepiness and nocturnal insomnia. Fibromyalgia is a common concomitant (73, 74) and is strongly associated with sleep disturbances, including abnormal sleep architecture (75). Chronic fatigue and orthostatic intolerance are common in hEDS (76). Hakim and Grahame (14) demonstrated for the first time the significantly increased risk of these symptoms in hEDS. Wandele et al. (77) concluded that autonomic symptoms contribute to the burden of symptoms such as fatigue, dizziness, fainting, syncope, memory, and concentration problems (56–58).
Results in our study showed that pain in the lower limbs was referred by the majority and “growing pain” by more than one third of the total sample, as well as the more the total Beighton score increases, there is a tendency not to have “growing pain.” Matsudo et al. (60) corroborate our results. These authors also identified the lower limbs as the most predominant location for “growing pain.” Early recognition and appropriate treatment of problems such as sleep function, mobility, chronic pain, and psychological conditions are important for successful holistic treatment of patients with EDS (61).
Psychosocial aspects are multifactorial and suggestive of manifestations since childhood, influenced by the composition of less robust tissues, with consequences on body mechanics and motor performance in daily, instrumental, recreational, sports, and occupational activities. Added to these factors, the manifestation of pain since childhood, which together may justify the psychosocial implications, with damage to social inclusion.
In the total sample, the JH characteristic prevails in the upper limbs of female children, adolescents and adults, with a total Beighton score ≥6. Most sit in the “concave” position and less than half also sit in the “W” position and with atypical hand postures. The higher Beighton scores, which include the upper limbs, show a tendency to not crawl or crawl differently, delayed ambulation, and impaired school performance. The predominance of JH in the upper limbs is suggestive of a justification for not crawling or crawling differently. Characteristics of atypical motor performance in hands and sitting posture, in addition to fatigue, pain since childhood, anxiety, apathy, depression, sleep disorders, stigmatization, attention deficit, spatial and/or temporal orientation impairment, and social isolation are characteristics. suggestive of psychosocial implications at different ages. Future studies with motor and psychosocial aspects of people with JH will help to identify the phenotype of this population and consequent guidance for clinical management based on the motor and psychosocial aspects of people with JH.
Data Availability Statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
The studies involving human participants were reviewed and approved by Comitê de ética em pesquisa—CEP—Faculdade de Medicina de São José do Rio Preto. Written informed consent from the participants' legal guardian/next of kin was not required to participate in this study in accordance with the national legislation and the institutional requirements.
All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
1. De Paepe A, Malfait F. The Ehlers-Danlos syndrome, a disorder with many faces. Clin Genet. (2012) 82:1–11. doi: 10.1111/j.1399-0004.2012.01858.x
2. Malfait F, Francomano C, Byers P, Belmont J, Berglund B, Black J, et al. The 2017 International classification of the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. (2017) 175:8–26. doi: 10.1002/ajmg.c.31552
3. Grahame R. Joint hypermobility: emerging disease or illness behaviour? Clin Med (Lond). (2013) 13 Suppl 6:s50–2. doi: 10.7861/clinmedicine.13-6-s50
4. Castori M, Colombi M. Generalized joint hypermobility, joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type. Am J Med Genet C Semin Med Genet. (2015) 169C:1–5. doi: 10.1002/ajmg.c.31432
5. Beighton P, Solomon I, Soskolne L. Articular mobility in an African population. Ann Rheum Dis. (1973) 32:413–8. doi: 10.1136/ard.32.5.413
6. Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A, et al. framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet. (2017) 175:148–57. doi: 10.1002/ajmg.c.31539
7. Malfait S, Eeckloo K, Van Biesen W, Van Hecke A. The effectiveness of bedside handovers: a multilevel, longitudinal study of effects on nurses and patients. J Adv Nurs. (2019) 75:1690–701. doi: 10.1111/jan.13954
8. Copetti M, Morlino S, Colombi M, Grammatico P, Fontana A, Castori M. Severity classes in adults with hypermobile Ehlers-Danlos syndrome/hypermobility. Spectrum disorders: A pilot study of 105 Italian patients. Rheumatology. (2019) 58:1722–30. doi: 10.1093/rheumatology/kez029
9. Lamari NM, Chueire AG, Cordeiro JA. Analysis of joint mobility patterns among preschool children. São Paulo Med J. (2005) 123:119–23. doi: 10.1590/s1516-31802005000300006
10. Remvig L, Jensen DV, Ward RC. Are diagnostic criteria for general joint hypermobility and benign joint hypermobility syndrome based on reproducible and valid tests? A review of the literature. J Rheumatol. (2007) 34:798–803.
11. Stern CM, Pepin MJ, Stoler JM, Kramer DE, Spencer SA, Stein CJ. Musculoskeletal conditions in a pediatric population with Ehlers-Danlos Syndrome. J Pediatr. (2017) 181:261–6. doi: 10.1016/j.jpeds.2016.10.078
12. Rikken-Bultman DG, Wellink L, van Dongen PW. Hypermobility in two Dutch school populations. Eur J Obstet Gynecol Reprod Biol. (1997) 73:189–92. doi: 10.1016/s0301-2115(97)02745-0
13. Lamari NM, Lamari MM. Characterization of brazilian children with joint hypermobility. Int J Physiatry. (2016) 2:011. doi: 10.23937/2572-4215.1510011
14. Hakim AJ, Grahame R. Non-musculoskeletal symptoms in joint hypermobility syndromeIndirect evidence for autonomic dysfunction? Rheumatology. (2004) 43:1194–5. doi: 10.1093/rheumatology/keh279
15. Quatman CE, Ford KR, Myer GD, Paterno MV, Hewett TE. The effects of gender and pubertal status on generalized joint laxity in young athletes. J Sci Med Sport. (2008) 11:257–63. doi: 10.1016/j.jsams.2007.05.005
16. Demmler JC, Atkinson MD, Reinhold EJ, Choy E, Lyons RA, Brophy ST. Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: a national electronic cohort study and case-control comparison. BMJ Open. (2019) 9:e031365. doi: 10.1136/bmjopen-2019-031365
17. Engelbert RH, Bank RA, Sakkers RJ, Helders PJ, Beemer FA, Uiterwaal CS. Pediatric generalized joint hypermobility with and without musculoskeletal complaints: a localized or systemic disorder? Pediatrics. (2003) 111:e248–54. doi: 10.1542/peds.111.3.e248
18. Scheper MC, de Vries JE, de Vos R, Verbunt J, Nollet F, Engelbert RH. Generalized joint hypermobility in professional dancers: a sign of talent or vulnerability? Rheumatology. (2013) 52:651–8. doi: 10.1093/rheumatology/kes220
19. Lamari MM, Lamari NM, Medeiros MP, Pavarino EC. Signos y Síntomas en niños y adolescentes con Hipermovilidad Articular: Un estudio transversal cuantitativo observacional. Rev Chil Reumatol. (2020) 36:42–53. Available online at: https://sochire.cl/wp-content/uploads/2021/09/r-928-1-1599230662.pdf
20. Mintz-Itkin R, Lerman-Sagie T, Zuk L, Itkin-Webman T, Davidovitch M. Does physical therapy improve outcome in infants with joint hypermobility and benign hypotonia? J Child Neurol. (2009) 24:714–9. doi: 10.1177/0883073808329526
21. Sahin F, Yilmaz F, Ozmaden A, Kotevolu N, Sahin T, Kuran B. Reliability and validity of the Turkish version of the Berg Balance Scale. J Geriatr Phys Ther. (2008) 31:32–7. doi: 10.1519/00139143-200831010-00006
22. Rombaut L, Malfait F, De Wandele I, Cools A, Thijs Y, De Paepe A, et al. Medication, surgery, and physiotherapy among patients with the hypermobility type of Ehlers-Danlos syndrome. Arch Phys Med Rehabil. (2011) 92:1106–12. doi: 10.1016/j.apmr.2011.01.016
23. Rombaut L, Malfait F, De Wandele I, Thijs Y, Palmans T, De Paepe A, et al. Balance, gait, falls, and fear of falling in women with the hypermobility type of Ehlers-Danlos syndrome. Arthritis Care Res. (2011) 63:1432–9. doi: 10.1002/acr.20557
24. Clayton HA, Cressman EK, Henriques DY. Proprioceptive sensitivity in Ehlers-Danlos syndrome patients. Exp Brain Res. (2013) 230:311–21. doi: 10.1007/s00221-013-3656-4
25. Grahame R, Hakim AJ. Arachnodactyly—a key to diagnosing heritable disorders of connective tissue. Nat Rev Rheumatol. (2013) 9:358–64. doi: 10.1038/nrrheum.2013.24
26. Bravo JF. Síndrome de Ehlers-Danlos con especial énfasis en el síndrome de hiperlaxitud articular. Rev Med Chil. (2009) 137:1488–97. doi: 10.4067/S0034-98872009001100013
27. Tinkle BT, Levy HP. Symptomatic joint hypermobility: the hypermobile type of Ehlers-Danlos Syndrome and the Hypermobility Spectrum Disorders. Med Clin North Am. (2019) 103:1021–33. doi: 10.1016/j.mcna.2019.08.002
28. Jasiewicz B, Potaczek T, Tesiorowski M, Lokas K. Spine deformities in patients with Ehlers-Danlos syndrome, type IV—late results of surgical treatment. Scoliosis. (2010) 5:26. doi: 10.1186/1748-7161-5-26
29. Tibbo ME, Wyles CC, Houdek MT, Wilke BK. Outcomes of primary total knee arthroplasty in patients with Ehlers-Danlos syndromes. J Arthroplasty. (2019) 34:315–8. doi: 10.1016/j.arth.2018.09.079
30. Nourissat G, Vigan M, Hamonet C, Doursounian L, Deranlot J. Diagnosis of Ehlers-Danlos syndrome after a first shoulder dislocation. J Shoulder Elbow Surg. (2018) 27:65–9. doi: 10.1016/j.jse.2017.05.028
31. Wolf JM, Cameron KL, Owens BD. Impact of joint laxity and hypermobility on the musculoskeletal system. J Am Acad Orthop Surg. (2011) 19:463–71. doi: 10.5435/00124635-201108000-00002
32. Vareková R, Vareka I, Janura M, Svoboda Z, Elfmark M. Evaluation of postural asymmetry and gross joint mobility in elite female volleyball athletes. J Hum Kinet. (2011) 29:5–13. doi: 10.2478/v10078-011-0034-9
33. Rietveld AB. Dancers' and musicians' injuries. Clin Rheumatol. (2013) 32:425–34. doi: 10.1007/s10067-013-2184-8
34. Juul-Kristensen B, Johansen K, Hendriksen P, Melcher P, Sandfeld J, Jensen BR. Girls with generalized joint hypermobility display changed muscle activity and postural sway during static balance tasks. Scand J Rheumatol. (2016) 45:57–65. doi: 10.3109/03009742.2015.1041154
35. Yao Q, Wang S, Shin JH Li G, Wood K. Motion characteristics of the lumbar spinous processes with degenerative disc disease and degenerative spondylolisthesis. Eur Spine J. (2013) 22:2702–9. doi: 10.1007/s00586-013-2918-y
36. Sperotto F, Balzarin M, Parolin M, Monteforte N, Vittadello F, Zulian F. Joint hypermobility, growing pain and obesity are mutually exclusive as causes of musculoskeletal pain in schoolchildren. Clin Exp Rheumatol. (2014) 32:131–6. Available online at: https://www.clinexprheumatol.org/abstract.asp?a=6570
37. Russek LN, Stott P, Simmonds J. Recognizing and effectively managing hypermobility-related conditions. Phys Ther. (2019) 99:1189–200. doi: 10.1093/ptj/pzz078
38. Zarate N, Farmer AD, Grahame R, Mohammed SD, Knowles CH, Scott SM, et al. Unexplained gastrointestinal symptoms and joint hypermobility: is connective tissue the missing link? Neurogastroenterol Motil. (2010) 22:252–e78. doi: 10.1111/j.1365-2982.2009.01421.x
39. Baeza-Velasco C, Gély-Nargeot MC, Bulbena Vilarrasa A, Bravo JF. Joint hypermobility syndrome: problems that require psychological intervention. Rheumatol Int. (2011) 31:1131–6. doi: 10.1007/s00296-011-1839-5
40. Berglund B, Pettersson C, Pigg M, Kristiansson P. Self-reported quality of life, anxiety and depression in individuals with Ehlers-Danlos syndrome (EDS): a questionnaire study. BMC Musculoskelet Disord. (2015) 16:89. doi: 10.1186/s12891-015-0549-7
41. Hershenfeld SA, Wasim S, McNiven V, Parikh M, Majewski P, Faghfoury H, et al. Psychiatric disorders in Ehlers-Danlos syndrome are frequent, diverse and strongly associated with pain. Rheumatol Int. (2016) 36:341–8. doi: 10.1007/s00296-015-3375-1
42. Tinkle B, Castori M, Berglund B, Cohen H, Grahame R, Kazkaz H, et al. Hypermobile EhlersDanlos syndrome (aka Ehlers-Danlos syndrome type III and Ehlers-Danlos syndrome hypermobility type): clinical description and natural history. Am J Med Genet C Semin Med Genet. (2017) 175:48–69. doi: 10.1002/ajmg.c.31538
43. Baeza-Velasco C, Pailhez G, Bulbena A, Baghdadli A. Joint hypermobility and the heritable disorders of connective tissue: clinical and empirical evidence of links with psychiatry. Gen Hosp Psychiatry. (2015) 37:24–30. doi: 10.1016/j.genhosppsych.2014.10.002
44. Bulbena A, Pailhez G, Bulbena-Cabré A, Mallorquí-Bagué N, Baeza-Velasco C. Joint hypermobility, anxiety and psychosomatics: two and a half decades of progress toward a new phenotype. Adv Psychosom Med. (2015) 34:143–57. doi: 10.1159/000369113
45. Vaivre-Douret L. Developmental coordination disorders: state of art. Neurophysiol Clin. (2014) 44:13–23. doi: 10.1016/j.neucli.2013.10.133
46. To M, Strutton PH, Alexander CM. Central fatigue is greater than peripheral fatigue in people with joint hypermobility syndrome. J Electromyogr Kinesiol. (2019) 48:197–204. doi: 10.1016/j.jelekin.2019.07.011
47. Baeza-Velasco C, Bourdon C, Montalescot L, de Cazotte C, Pailhez G, Bulbena A, et al. Low- and high-anxious hypermobile Ehlers-Danlos syndrome patients: comparison of psychosocial and health variables. Rheumatol Int. (2018) 38:871–8. doi: 10.1007/s00296-018-4003-7
48. Bulbena A, Baeza-Velasco C, Bulbena-Cabré A, Pailhez G, Critchley H, Chopra P, et al. Psychiatric and psychological aspects in the Ehlers-Danlos syndromes. Am J Med Genet C Semin Med Genet. (2017) 175:237–45. doi: 10.1002/ajmg.c.31544
49. Bulbena-Cabre A, Duñó L, Almeda S, Batlle S, Camprodon-Rosanas E, Martín-Lopez LM, et al. Joint hypermobility is a marker for anxiety in children. Rev Psiquiatr Salud Ment. (2019) 12:68–76. doi: 10.1016/j.rpsm.2019.01.004
50. de Vries J, Verbunt J, Stubbe J, Visser B, Ramaekers S, Calders P, et al. Generalized Joint Hypermobility and Anxiety in Adolescents and Young Adults, the Impact on Physical and Psychosocial Functioning. Healthcare. (2021) 9:525. doi: 10.3390/healthcare9050525
51. Castori M, Morlino S, Celletti C, Celli M, Morrone A, Colombi M, et al. Management of pain and fatigue in the joint hypermobility syndrome (a.k.a. Ehlers-Danlos syndrome, hypermobility type): principles and proposal for a multidisciplinary approach. Am J Med Genet A. (2012) 158A:2055–70. doi: 10.1002/ajmg.a.35483
52. Voermans NC, Knoop H, Bleijenberg G, van Engelen BG. Fatigue is associated with muscle weakness in Ehlers-Danlos syndrome: an explorative study. Physiotherapy. (2011) 97:170–4. doi: 10.1016/j.physio.2010.06.001
53. Palomo-Toucedo IC, Leon-Larios F, Reina-Bueno M, Vázquez-Bautista MDC, Munuera-Martínez PV, Domínguez-Maldonado G. Psychosocial Influence of Ehlers-Danlos syndrome in daily life of patients: a qualitative study. Int J Environ Res Public Health. (2020) 17:6425. doi: 10.3390/ijerph17176425
54. Bennett SE, Walsh N, Moss T, Palmer S. Understanding the psychosocial impact of joint hypermobility syndrome and Ehlers-Danlos syndrome hypermobility type: a qualitative interview study. Disabil Rehabil. (2021) 43:795–804. doi: 10.1080/09638288.2019.1641848
55. Clark CJ, Knight I. A humanisation approach for the management of Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome-Hypermobility Type (JHS/EDS-HT). Int J Qual Stud Health Well-being. (2017) 12:1371993. doi: 10.1080/17482631.2017.1371993
56. Lamari NM, Medeiros MP, Lamari MM. Systemic manifestations of Ehlers-Danlos syndrome hypermobility type. MOJ Cell Sci Rep. (2017) 4:30–3.
57. Moss C, Fernandez-Mendoza J, Schubart J, Sheehan T, Schilling AL, Francomano C, et al. Nighttime sleep and daytime functioning in Ehlers-Danlos syndrome: a cohort study of syndrome subtypes. Sleep. (2018) 41:A343–A343. https://doi.org/10.1093/sleep/zsy061.923
58. Miliken L, Sedky K. Ehlers-Danlos syndrome and narcolepsy: an incidental relationship? J Sleep Dis Res. (2019) 1:16–20. doi: 10.14302/issn.2574-4518.jsdr-18-2511
59. Murray B, Yashar BM, Uhlmann WR, Clauw DJ, Petty EM. Ehlers-Danlos syndrome, hypermobility type: a characterization of the patients' lived experience. Am J Med Genet A. (2013) 161A:2981–8. doi: 10.1002/ajmg.a.36293
60. Matsudo SM, Paschoal VCP, Amancio OMS. Atividade física e sua relação com o crescimento e a maturação biológica de crianças. Cad Nutr. (1997) 14:1–12.
61. Gensemer C, Burks R, Kautz S, Judge DP, Lavallee M, Norris RA. Hypermobile Ehlers-Danlos syndromes: complex phenotypes, challenging diagnoses, and poorly understood causes. Dev Dyn. (2021) 250:318–44. doi: 10.1002/dvdy.220
62. Yazgan P, Geyikli I, Zeyrek D, Baktiroglu L, Kurcer MA. Is joint hypermobility important in prepubertal children? Rheumatol Int. (2008) 28:445–51. doi: 10.1007/s00296-008-0528-5
63. Morris SL, O'Sullivan PB, Murray KJ, Bear N, Hands B, Smith AJ. Hypermobility and musculoskeletal pain in adolescents. J Pediatr. (2017) 181:213–221.e1. doi: 10.1016/j.jpeds.2016.09.060
64. Hakim AJ, Grahame R. A simple questionnaire to detect hypermobility: An adjunct to the assessment of patients with diffuse musculoskeletal pain. Int J Clin Pract. (2003) 57:163–6.
65. Castori M, Celletti C, Camerota F, Grammatico P. Chronic fatigue syndrome is commonly diagnosed in patients with Ehlers-Danlos syndrome hypermobility type/joint hypermobility syndrome. Clin Exp Rheumatol. (2011) 29:597–8.
66. Sánchez-Meca J, Rosa-Alcázar AI, Iniesta-Sepúlveda M, Rosa-Alcázar A. Differential efficacy of cognitive-behavioral therapy and pharmacological treatments for pediatric obsessive-compulsive disorder: a meta-analysis. J Anxiety Disord. (2014) 28:31–44. doi: 10.1016/j.janxdis.2013.10.007
67. Ali Zekry O, Ali Ahmed M, Ali Elsayed Abd Elwahid H. The impact of fatigue on health related quality of life in adolescents with benign joint hypermobility syndrome. Egypt Rheumatol. (2013) 35:77–85. https://doi.org/10.1016/j.ejr.2012.12.002
68. Pacey V, Tofts L, Adams RD, Munns CF, Nicholson LL. Quality of life prediction in children with joint hypermobility syndrome. J Paediatr Child Health. (2015) 51:689–95. doi: 10.1111/jpc.12826
69. Beckers AB, Keszthelyi D, Fikree A, Vork L, Masclee A, Farmer AD, et al. Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: a review for the gastroenterologist. Neurogastroenterol Motil. (2017) 29:13013. doi: 10.1111/nmo.13013
70. Eccles JA, Scott HE, Davies KA, Bond R, David AS, Harrison NA, Critchley HD. Joint hypermobility and its relevance to common mental illness in adolescents: a population-based longitudinal study. medRxiv 2020.09.14.2019. https://doi.org/10.1101/2020.09.14.20191130
71. Baeza-Velasco C, Bulbena A, Polanco-Carrasco R, Jaussaud R. Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers-Danlos syndrome hypermobility-type: a narrative review. Disabil Rehabil. (2019) 41:1110–8. doi: 10.1080/09638288.2017.1419294
72. Voermans NC, Knoop H, Bleijenberg G, van Engelen BG. Pain in ehlers-danlos syndrome is common, severe, and associated with functional impairment. J Pain Symptom Manage. (2010) 40:370–8. doi: 10.1016/j.jpainsymman.2009.12.026
73. Ofluoglu D, Gunduz OH, Kul-Panza E, Guven Z. Hypermobility in women with fibromyalgia syndrome. Clin Rheumatol. (2006) 25:291–3. doi: 10.1007/s10067-005-0040-1
74. Ting TV, Hashkes PJ, Schikler K, Desai AM, Spalding S, Kashikar-Zuck S. The role of benign joint hypermobility in the pain experience in juvenile fibromyalgia: An observational study. Pediatr Rheumatol Online J. (2012) 10:16. doi: 10.1186/1546-0096-10-16
75. Besteiro González JL, Suárez Fernández TV, Arboleya Rodríguez L, Muñiz J, Lemos Giráldez S, Alvarez Fernández A. Sleep architecture in patients with fibromyalgia. Psicothema. (2011) 23:368–73.
76. Mathias CJ, Low DA, Iodice V, Owens AP, Kirbis M, Grahame R. Postural tachycardia syndrome-current experience and concepts. Nat Rev Neurol. (2011) 8:22–34. doi: 10.1038/nrneurol.2011.187
77. De Wandele I, Calders P, Peersman W, Rimbaut S, De Backer T, Malfait F, et al. Autonomic symptom burden in the hypermobility type of Ehlers-Danlos syndrome: a comparative study with two other EDS types, fibromyalgia, and healthy controls. Semin Arthritis Rheum. (2014) 44:353–61. doi: 10.1016/j.semarthrit.2014.05.013
Keywords: Ehlers-Danlos syndrome, pain, joint hypermobility, articular instability, fatigue, anxiety, psychosocial
Citation: Lamari MM, Lamari NM, Araujo-Filho GM, Medeiros MP, Pugliesi Marques VR and Pavarino ÉC (2022) Psychosocial and Motor Characteristics of Patients With Hypermobility. Front. Psychiatry 12:787822. doi: 10.3389/fpsyt.2021.787822
Received: 01 October 2021; Accepted: 29 December 2021;
Published: 28 March 2022.
Edited by:Antonio Bulbena, Universitat Autònoma de Barcelona, Spain
Reviewed by:Leslie Russek, Clarkson University, United States
Carla Masala, University of Cagliari, Italy
Copyright © 2022 Lamari, Lamari, Araujo-Filho, Medeiros, Pugliesi Marques and Pavarino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Neuseli M. Lamari, firstname.lastname@example.org