Original Research ARTICLE
Recurrence is a noticeable cause of rifampicin-resistant Mycobacterium tuberculosis in the elderly in Jiangxi, China
- 1First Affiliated Hospital of Nanchang University, China
- 2Jiangxi Chest Hospital, China
- 3Department of clinical laboratory, Jiangxi Chest Hospital, China
Rifampicin-resistant tuberculosis (RR-TB) is widespread in elder people in Jiangxi Province, China, but the cause is unknown. This study would investigate the incidence of RR-TB and risk factors in elder people within a hospital setting in China. Here, we performed retrospective cohort study, including a comparative study to analyse RR-TB with rifampicin-susceptible TB (RS-TB) and 15-loci MIRU-VNTR method to determine relapse or reinfection. The results showed 23 recurrent cases existed in 151 RR-TB elderly tuberculosis patients, correspondingly, 24 in 466 RS-TB cases during this period. At the same time, elderly TB recurrence had significant difference between RR-TB and RS-TB (OR=0.35, 95%CI: 0.14-0.88; 2=5.28, P = 0.03). Comparing the risk factors of RR-TB and RS-TB in elderly patients, education level, age and pulmonary cavity were inextricably linked to elderly RR-TB. Furthermore, pulmonary cavity, HIV infection and alcohol consumption were associated with elderly RR-TB recurrence. These findings proved recurrence was an important source of elderly RR-TB, and elderly RR-TB prevention needs to focus on standard treatment.
Keywords: Tuberculosis, Recurrence, Rifampicin-resistant, elderly patients, China
Received: 26 Feb 2019;
Accepted: 17 Jun 2019.
Edited by:Aleksandra Barac, Faculty of Medicine, University of Belgrade, Serbia
Reviewed by:Ana Afonso, University of São Paulo, Brazil
JOSE R. LAPA E SILVA, Federal University of Rio de Janeiro, Brazil
Copyright: © 2019 Chen, peng, xiong, luo, peng, zou and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
MD, PhD. jin l. zou, First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China, Zou.email@example.com
MD, PhD. Sen K. Chen, First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China, firstname.lastname@example.org