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ORIGINAL RESEARCH article

Front. Public Health
Sec. Aging and Public Health
Volume 12 - 2024 | doi: 10.3389/fpubh.2024.1364735
This article is part of the Research Topic Metabolic Diseases and Healthy Aging: Prevention and Public Health Policy Based on Risk Factors View all 5 articles

Associations between special diet and incidence risk of osteoporosis: A Mendelian randomization study

Provisionally accepted
Changwen Zhou Changwen Zhou lixue yang lixue yang *ce liu ce liu *hongzhong ma hongzhong ma *feng yang feng yang *liheng chen liheng chen *
  • Shaanxi University of Chinese Medicine, Xianyang, China

The final, formatted version of the article will be published soon.

    Introduction: Osteoporosis is a prevalent challenge in clinical orthopedics, affecting a significant percentage of individuals aged 50 and above. The goal of this study was to comprehensively understand the relationships between a specialized dietary regimen and the risk of developing osteoporosis.Methods: This study employed extensive genome-wide association study (GWAS) summary statistics derived from the UK Biobank. It encompassed 8 kinds of special diets and 7 datasets pertaining to osteoporosis and associated symptoms. The principal analytical approach employed was the inverse-variance weighted method. Additionally, sensitivity analysis was employed to elucidate the diverse multiplicity patterns observed in the final model.Results: Our results showed that there is significant evidence that a gluten-free diet is associated with osteoporosis [odds ratio (OR): 1.080, 95% confidence interval (CI): 1.048-1.112, p=4.23E-07)]. Furthermore, there exists a suggestive link between the three distinct dietary approaches and osteoporosis [(OR: 0.949, 95%CI: 0.929-0.970, p=3.00E-06) for comprehensive consumption; (OR: 1.053, 95%CI: 1.018-1.089, p=2.23E-03) for abstaining from wheat consumption; (OR: 1.036, 95%CI: 1.005-1.068, p=1.97E-02) for abstaining from sugar consumption]. No additional correlation between the special dietary regimens and osteoporosis has been observed.Conclusions: Our research has uncovered a notable correlation between a gluten-free diet and the occurrence of osteoporosis. Furthermore, it exerts a promoting influence on the onset of osteoporosis, which stands in direct contradiction to the therapeutic principles for Celiac Disease's complications. As such, a novel association among these three elements is postulated.

    Keywords: Osteoporosis, dietary habits, gluten-free diet, Mendelian randomization, Celiac Disease

    Received: 03 Jan 2024; Accepted: 06 May 2024.

    Copyright: © 2024 Zhou, yang, liu, ma, yang and chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    lixue yang, Shaanxi University of Chinese Medicine, Xianyang, China
    ce liu, Shaanxi University of Chinese Medicine, Xianyang, China
    hongzhong ma, Shaanxi University of Chinese Medicine, Xianyang, China
    feng yang, Shaanxi University of Chinese Medicine, Xianyang, China
    liheng chen, Shaanxi University of Chinese Medicine, Xianyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.