People with dementia commonly have neuropsychiatric symptoms such as depression, anxiety, apathy, agitation, delusions, hallucinations, and sleep disorders, among other symptoms (Cummings, 2021). There is evidence that ~97% of people with dementia experience at least one neuropsychiatric symptom since the onset of dementia symptoms (Steinberg et al., 2008), and new research suggests neuropsychiatric symptoms may be present even in preclinical and early clinical stages of cognitive impairment (Eikelboom et al., 2021). However, it can be difficult to identify and treat these symptoms across stages of cognitive decline and neurodegeneration (Lyketsos, 2015). In preclinical stages, it can be challenging to parse out whether neuropsychiatric symptoms represent early manifestations of neurodegenerative disorders or are better explained by a primary psychiatric condition (Monastero et al., 2009). In addition, it is still poorly understood how trajectories of neuropsychiatric symptoms progress over time in neurodegenerative disease (Borsje et al., 2015), and whether neuropsychiatric symptoms may have a negative prognostic value for the progression of dementia (Peters et al., 2015).
Our Research Topic aims to highlight studies that focus on better understanding of the relationship between neuropsychiatric symptoms among neurodegenerative diseases. Understanding trajectories of neuropsychiatric symptoms will advance knowledge for earlier identification and treatment in individuals with Alzheimer's Disease and Related Dementias (ADRD). Characterizing molecular mechanisms underlying neuropsychiatric symptoms in ADRD will identify potential biological targets for drug development and repurposing efforts.
Research Topics of interest included the following:
Demographic effects on ADRD with potential implication on the study of neuropsychiatric symptoms in ADRD
Stanley et al. applied logistic regression analysis to determine gender-related differences in demographic and pharmacological factors in a large clinical sample of 9,290 individuals with Alzheimer's disease, 6,039 individuals with Vascular Dementia, and 412 individuals with mixed dementias: vascular-Alzheimer's disease. They found gender differences and similarities in age, medical history (e.g., tobacco use), and medication of individuals with Alzheimer's dementia, vascular dementia, and mixed dementias vascular-Alzheimer's disease, providing evidence for the necessity to investigate gender-related effects in ADRDs, including those probably associated with neuropsychiatric symptoms.
Valid psychometric tools to identify and determine meaningful changes of specific neuropsychiatric symptoms over time in ADRD
Meunier et al. conducted a post-hoc analysis of data from the brexpiprazole clinical program to determine a meaningful within-patient change (MWPC) threshold for the Cohen-Mansfield Agitation Inventory (CMAI) that quantifies the frequency of agitation behaviors in elderly persons. By analyzing data from 898 patients, the authors highlighted that a MWPC threshold of −20 points for the CMAI total score could predict dementia due to Alzheimer's disease in patients with agitation.
Epidemiological metrics of specific neuropsychiatric symptoms and their association with functional impairment in ADRD
Zhu et al. examined the prevalence and persistence of apathy in 676 well-characterized patients with Lewy Body Disease (LBD) and estimated the effect of apathy on functional impairment over time. They found that >50% of patients showed apathy both at baseline and follow-up evaluation, whereas apathy was strongly associated with greater functional impairment at baseline and faster rate of decline over time. Of note, these effects were beyond the effects on functional impairment from cognitive scores and parkinsonism, underscoring the importance of apathy evaluation in LBD.
Genetic basis and causal relationships between education and neuropsychiatric symptoms with potential implications in the study of ADRD
Chen et al. explored the shared genetic basis and causal relationships between educational attainment (EA) and neuropsychiatric disorders (NPDs) using the high-definition likelihood method, cross phenotype association study, transcriptome-wide association study and bidirectional Mendelian randomization with summary-level data for EA (N = 293,723) and NPDs (N range = 9,725 to 455,258). The authors identified significant genetic correlations between EA and 12 NPDs. Overall, the study revealed (a) 37 independent loci shared between EA and NPDs, (b) enriched shared genes in brain tissue, especially in the cerebellum, and (c) the role of three regions (6q16.1, 3p21.31, and 17q21.31) for the shared causes between EA and NPDs. The study provided evidence of potential biological pathways underlying both EA and NPDs.
Non-pharmacological treatment of neuropsychiatric symptoms in ADRD
Lastly, in a systematic review and meta-analysis study, González-Martín et al. focused on the effects of cognitive behavioral therapies (CBT) on depression in older adults with Alzheimer's disease. Despite the heterogeneity in the protocols used across the 11 studies included, the authors reported that psychosocial CBT is effective in improving depression in individuals with Alzheimer's disease.
In conclusion, this Research Topic of studies promoted discussion on neuropsychiatric symptoms in ADRD, highlighting the role of demographic and genetic factors and providing low-cost measures to effectively diagnose and treat ADRD-associated neuropsychiatric symptoms.
Statements
Author contributions
FC: Conceptualization, Writing – original draft, Writing – review & editing. CB: Conceptualization, Writing – original draft, Writing – review & editing. GP: Conceptualization, Writing – review & editing. CF: Conceptualization, Writing – review & editing. CM: Writing – original draft, Writing – review & editing.
Acknowledgments
We thank all authors for contributing to this Research Topic.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1
BorsjeP.WetzelsR. B.LucassenP. L.PotA. M.KoopmansR. T. (2015). The course of neuropsychiatric symptoms in community-dwelling patients with dementia: a systematic review. Int. Psychogeriatr.27, 385–405. 10.1017/S1041610214002282
2
CummingsJ. (2021). The role of neuropsychiatric symptoms in research diagnostic criteria for neurodegenerative diseases. Am. J. Geriatr. Psychiatr.29, 375–383. 10.1016/j.jagp.2020.07.011
3
EikelboomW. S.van den BergE.SingletonE. H.BaartS. J.CoesmansM.LeeuwisA. E.et al. (2021). Neuropsychiatric and cognitive symptoms across the Alzheimer disease clinical spectrum: cross-sectional and longitudinal associations. Neurology97, e1276–e1287. 10.1212/WNL.0000000000012598
4
LyketsosC. G. (2015). Neuropsychiatric symptoms in dementia: overview and measurement challenges. J. Prev. Alzheimers Dis.2, 155–156. 10.14283/jpad.2015.60
5
MonasteroR.MangialascheF.CamardaC.ErcolaniS.CamardaR. (2009). A systematic review of neuropsychiatric symptoms in mild cognitive impairment. J. Alzheimer's Dis.18, 11–30. 10.3233/JAD-2009-1120
6
PetersM. E.SchwartzS.HanD.RabinsP. V.SteinbergM.TschanzJ. T.et al. (2015). Neuropsychiatric symptoms as predictors of progression to severe Alzheimer's dementia and death: the Cache County Dementia Progression Study. Am. J. Psychiatry172, 460–465. 10.1176/appi.ajp.2014.14040480
7
SteinbergM.ShaoH.ZandiP.LyketsosC. G.Welsh-BohmerK. A.NortonM. C.et al. (2008). Point and 5-year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study. Int. J. Geriatr. Psychiatr.23, 170–177. 10.1002/gps.1858
Summary
Keywords
neuropsychiatric symptoms, Alzheimer's disease, dementias, agitation, Lewy Body Disease, apathy, cognitive behavioral therapies, depression
Citation
Christidi F, Bakirtzis C, Pathak GA, Fredericks C and Munro C (2024) Editorial: Crosslinking neuropsychiatric symptoms across the continuum of Alzheimer's disease and related dementias. Front. Dement. 3:1498924. doi: 10.3389/frdem.2024.1498924
Received
19 September 2024
Accepted
23 October 2024
Published
06 November 2024
Volume
3 - 2024
Edited and reviewed by
Florian Riese, University of Zurich, Switzerland
Updates
Copyright
© 2024 Christidi, Bakirtzis, Pathak, Fredericks and Munro.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Foteini Christidi christidi.f.a@gmail.com
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.