Abstract
Tension pneumoperitoneum is characterized by excessive accumulation of gas in the peritoneal cavity, which leads to cardiorespiratory distress. We present the case of a 4-year-old female Labrador retriever who presented with a severe abdominal distension and panting. Radiography revealed a large volume of free gas in the peritoneal cavity with decreased serosal detail. After emergency needle decompression, ultrasound-guided aspiration of the peritoneal effusion helped confirm septic peritonitis. Computed tomography revealed a gastric mass measuring approximately 3.7 × 5.0 × 5.5 cm, which was suspected to have caused the gastric perforation. A large volume of free gas was present in the peritoneal cavity, causing compression and centralization of the abdominal organs. A low-attenuating cleft suggestive of perforation site near the gastric mass was also observed. Exploratory laparotomy confirmed gastric perforation of approximately 2.2 cm adjacent to the gastric mass. The patient was finally diagnosed with tension pneumoperitoneum caused by gastric perforation. The mass was resected with a 1–2-cm surgical margin, and imprinting cytology indicated gastric carcinoma. The patient was aggressively treated with fluid, analgesic, antithrombotic, and antibacterial therapy. However, the patient’s condition continued to deteriorate, and euthanasia was performed at the owner’s request. Our report is the first to describe the multimodal imaging features of a dog with tension pneumoperitoneum secondary to gastric perforation caused by gastric neoplasm.
1 Introduction
Tension pneumoperitoneum (TPP) is a type of pneumoperitoneum characterized by the excessive accumulation of gas in the peritoneal cavity, leading to cardiorespiratory distress (1–5). Excessive gas within the peritoneal cavity increases intraabdominal pressure and pushes the diaphragm cranially, leading to respiratory distress accompanied by tachypnea (1, 2). Excess gas compresses the caudal vena cava and reduces venous return, ultimately leading to hypotension and tachycardia (1, 2). Therefore, urgent decompression is necessary to reduce intraabdominal pressure.
For the prompt diagnosis of TPP, diagnostic imaging plays a pivotal role. Distinctive signs indicative of TPP, including cranial displacement of the diaphragm, medial displacement of the liver, central crowding of viscera, and the presence of massive pneumoperitoneum, can be identified through abdominal radiography (2, 6). To investigate the causes of TPP, Computed tomography can be helpful. The most common causes of TPP, gastrointestinal (GI) perforation, is characterized on CT by the discontinuity of the GI wall at the site of perforation or by accompanying indirect findings suggestive of GI perforation.
2 Case description
A 4-year-old intact female Labrador retriever dog, weighing 21 kg, presented with anorexia and lethargy for 20 days. Physical examination revealed severe abdominal distension, fever (40.7°C), increased heart rate (132 bpm) and breathing difficulty accompanied by panting.
Blood examination revealed leukocytosis (35.1 × 109 cells/L; reference range: 6–17 × 109 cells/L) with severe neutrophilia (30.3 × 109 cells/L; reference range: 3.9–8 × 109 cells/L) and monocytosis (2.3 × 109 cells/L; reference range: 0.2–1.1 × 109 cells/L). Plasma biochemical analysis revealed increased levels of alkaline phosphatase (825 U/L; reference range: 29–155 U/L), amylase (1768 U/L; reference range: 388–1,007 U/L), lactate (4.9 mg/dL; reference range: 0.5–2.5 mg/dL), C-reactive protein (59.9 mg/L: reference range: 0–20 mg/L), and D-dimer (2.0 mg/dL; reference range: 0–0.3 mg/dL). The serum glucose level was within the reference range (77 mg/dL; reference range: 67–147 mg/dL).
Abdominal radiography (Titan 2000; Comed Medical Systems Co., Ltd., Seoul, Korea; 82 kVp, 10.2 mAs, 320 mA) revealed a large volume of free gas in the peritoneal space (Figures 1A,C) with marked abdominal distension and cranial displacement of the diaphragm. Peritoneal gas was observed outlining the outer wall of the small bowel. In addition, a radiopaque stripe of approximately 7 mm in thickness and 25 cm in length was identified on the mid-abdomen, suggestive of a ligament or peritoneal reflection. The overall abdominal serosal detail was reduced. The radiographic findings indicated that the panting and breathing distress were caused by massive pneumoperitoneum. Emergent needle decompression and peritoneal effusion sampling were performed; however, despite improvement in respiration and reduction in abdominal distension, a large amount of free gas was persistent (Figures 1B,D). In the peritoneal fluid analysis, a significant elevation in white blood cells (> 17 × 109 cells/L; reference range: < 7 × 109 cells/L) and total protein (3.6 g/dL; reference range: < 2.0 g/dL) was observed and the glucose concentration was 28 mg/dL.
Figure 1
Computed tomography (CT) was performed using a 164-detector row CT scanner (Brivo CT 385; GE Medical Systems, Milwaukee, WI, United States; 120 kVp, 110 mAs, 1.25-mm slice thickness) with the dog under general anesthesia and positioned in ventral recumbency. A power injector (CT Power Injector; GE Medical Systems, Milwaukee, WI, United States) was used to administer 600 mg iodine/kg iohexol (Omnihexol 300; Korea United Pharmaceutical, Seoul, Korea). In post-contrast images, we found a gastric mass with homogeneous enhancement, measuring approximately 3.7 × 5.0 × 5.5 cm and extending from the cardia to the fundus of the stomach (Figure 2). Small gas bubbles were present between the omentum and gastric mass (Figures 2A,B). A substantial amount of free gas was present in the peritoneal cavity (Figure 2), causing compression and centralization of the abdominal organs (Figures 3A–C). Diffuse peritoneal effusion and fat stranding were observed throughout the peritoneal cavity, particularly around the stomach (Figure 3D). Furthermore, a low-attenuating cleft that could be indicative of perforation site was observed near the gastric mass. These imaging findings led to a tentative diagnosis of gastric perforation caused by gastric neoplasia, resulting in TPP and peritonitis.
Figure 2
Figure 3
The dog underwent exploratory laparotomy for identifying and correcting the perforation site and performing peritoneal lavage. A gastric perforation site (Figure 2D) of approximately 2.2 cm was identified near the gastric mass. Severe generalized peritonitis with fibrin deposition along the peritoneum and slightly opaque yellow ascites were observed. The mass was resected with a surgical margin of 1 ~ 2 cm, and after peritoneal lavage and drainage, the abdomen was closed. Biopsy was not performed owing to a lack of the owner’s consent. However, imprinting cytology indicated gastric carcinoma. The patient was treated with fluid therapy, analgesic, antithrombotic agents, and antibacterial therapy. Despite aggressive treatment, the patient’s condition worsened, and euthanasia was performed the day after surgery at the owner’s request.
3 Discussion
In this case report, we described a case of TPP in a dog, in which imaging findings led to a tentative diagnosis of gastric perforation caused by gastric neoplasia, TPP, and peritonitis. GI perforation can cause TPP through a “one-way valve” mechanism, in which the liver and omentum covering the perforation site act as a valve, allowing air to escape from the GI tract but preventing it from reentering the tract (1, 2, 7). However, TPP is a rare consequence of GI tract perforation and can occur in conjunction with aerophagia (4). In the present case, aerophagia is likely to have occurred owing to panting caused by abdominal pain, ultimately leading to TPP (8). In addition, the omentum around the perforation site may have acted as a valve, preventing the air from reentering the stomach.
TPP has been reported to have gastrointestinal, pulmonary, and urological causes in humans. Previous studies showed that GI causes (27/36) were the most common (6). To date, three veterinary cases of TPP have been reported. Of them, one case was experimentally induced in a dog, whereas the remaining two occurred in cats and were caused by perforations in the stomach and duodenum (4, 5, 7). Although the number of cases is small, the present and previous cases indicate that GI perforation may be the primary cause of TPP in veterinary medicine, similar to that in humans. To the best of our knowledge, no cases of spontaneous TPP caused by gastric perforation in a dog has been reported. Here, we report a case of TPP caused by gastric perforation in a dog.
Gastric perforation in dogs has several causes, including gastric ulcers, neoplasms, abdominal trauma, and iatrogenic causes. It occurred in approximately 35–45% of dogs with gastroduodenal ulcerative disease and primary neoplasms (9–11). In this case, there was no history of trauma or iatrogenic factors, and the presence of perforation around the gastric mass suggests a diagnosis of spontaneous perforation due to gastric carcinoma. Spontaneous perforation caused by gastric tumor is known to occur when ulceration and tumor necrosis extend to the deep layers of the gastric wall, specifically the subserosa (11). While gastric wall rupture due to gastric cancer is reported to occur in humans at rates ranging from 0.56 to 3.9%, there have been no documented frequency of tumor induced perforation in dogs (12).
The diagnosis of TPP in humans is based on the clinical signs and abdominal radiographic findings (13). The clinical signs of TPP include tympanitic abdominal distension, respiratory distress, and hemodynamic collapse, which are associated with massive pneumoperitoneum. In the present case, breathing distress and tympanitic abdominal distension were observed. Further, the characteristic abdominal radiography findings of TPP in humans include cranial displacement of the diaphragm, saddle bag sign indicative of medial displacement of liver, central crowding of viscera, football sign indicative of massive pneumoperitoneum, where the abdominal cavity is outlined by gas, and Rigler sign indicative of large amounts of pneumoperitoneum when gas is outlining both sides of the bowel wall (2, 6). Additionally, a radiopaque stripe was identified on abdominal radiography. This finding can resemble those observed in humans with a massive pneumoperitoneum, attributed to peritoneal ligaments such as the falciform ligament or umbilical ligaments (13). However, it is important to note that in this case, imaging was performed in the prone position (ventral recumbency), as opposed to humans imaged in the supine position (dorsal recumbency). Therefore, there are anatomical differences in the identity of the radiopaque stripe, and it is considered to be associated with one of the peritoneal ligaments. Although the exact nature of the radiopaque stripe could not be precisely determined, its similarity to features observed in humans with massive pneumoperitoneum suggests that it could be helpful in the diagnosis of TPP (2, 3, 7).
In humans, CT findings of TPP include compression of multiple bowel loops by massive amount of gas, centralization of abdominal organs, and compression of the inferior vena cava. Similar findings were observed in our case, including compression of the small intestine and centralization of the abdominal organs. However, no compression of the caudal vena cava was observed; this may be attributable to the emergency decompression before CT or ventral recumbency during imaging, which differs from the position used during CT in humans. Therefore, the CT findings of TPP may be similar among dogs and humans, indicating that the CT diagnostic criteria used for humans may be applicable to dogs.
In humans, TPP caused by GI tract perforation requires laparotomy and continuous intraperitoneal drainage (2–7), and CT is a commonly used diagnostic tool to detect GI perforations. Discontinuities in the GI wall, which typically appear as low-attenuation clefts on CT, should be identified to accurately locate the perforation. The frequency of detecting these discontinuities is generally less than 50% (14, 15). Despite this low frequency, the predictive value for the site of perforation is relatively high, ranging from 82 to 90%. Indirect findings such as intestinal wall thickening, abnormal wall enhancement, abscess, and inflammatory masses located near the perforation site are also helpful in predicting the perforation site (16). In this case, there was an area around the gastric mass that raised suspicion of a perforation site; however, due to adhesion to the omentum, the presence of ascites, and a collapsed stomach, it was difficult to definitively confirm the perforation site (14). Despite the difficulty in accurately localizing the perforation site on CT, a perforation near the gastric mass was anticipated because of the focal gastric wall thickening (16, 17). From this perspective, CT may help not only to determine the need for laparotomy but also to plan the surgical procedure in patients with TPP.
The diagnosis of septic peritonitis is based on increased white blood cell count, higher total protein levels, and peritoneal fluid glucose concentration. In this case, we observed elevated white blood cells counts (> 17 × 109 cells/L; reference range: 7 × 109 cells/L), increased total protein levels (3.6 g/dL; reference range: <2.0 g/dL), and peritoneal fluid glucose levels consistently below 55 mg/dL (sensitivity 57%, specificity 100%), with a difference of more than 20 mg/dL (sensitivity 100%, specificity 100%) compared to the blood glucose level. This confirms the diagnosis of septic peritonitis (15, 18). Therefore, the abnormalities noted in the blood tests, including severe neutrophilia, monocytosis, increased C-reactive protein, and D-dimer levels, are indicated of severe inflammatory response.
In conclusion, TPP is a rare but life-threatening complication of gastric perforation in dogs. Imaging modalities, such as radiography and CT, are valuable tools for the diagnosis and detection of its underlying causes. In this case, massive pneumoperitoneum was detected on both radiography and CT, with characteristic findings such as gas outlining the peritoneal cavity, gas on both sides of the bowel wall, cranial displacement of the diaphragm, and a radiopaque stripe on abdominal radiographs. CT also revealed intra-abdominal visceral compression and centralization of the abdominal organs. Moreover, CT was particularly useful in diagnosing the underlying cause of TPP in the present case: gastric perforation caused by a gastric tumor.
Statements
Data availability statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.
Ethics statement
Ethical review and approval were not required for the animal study because the case report is a description of a clinical case. Written informed consent was obtained from the patients/participants for the publication of this case report.
Author contributions
MK: Conceptualization, Investigation, Writing – original draft, Writing – review & editing. JJ: Visualization, Writing – review & editing. CC: Visualization, Writing – review & editing. KE: Visualization, Writing – review & editing. JK: Conceptualization, Visualization, Writing – review & editing, Writing – original draft.
Acknowledgments
This paper was supported by Konkuk University in 2023.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1.
JooWJKuwaharaYAsakaYMizuDHaraSAriyoshiK. Tension pneumoperitoneum caused by intestinal perforation from underlying colon cancer: a case report. J Med Case Rep. (2020) 14, 112–6. doi: 10.1186/s13256-020-02437-2
2.
DasPMukherjeeRPathakDGangopadhyayAHalderSSinghSK. Tension pneumoperitoneum: a very rare complication of acute gangrenous appendicitis. Ann R Coll Surg Engl. (2016) 98:e197–9. doi: 10.1308/rcsann.2016.0240
3.
CanivetJLYansTPiretSFrerePBeguinY. Barotrauma-induced tension pneumoperitoneum. Acta Anaesth Belg. (2003) 54:233–6. PMID:
4.
ItohTNibeKNaganobuK. Tension pneumoperitoneum due to gastric perforation in a cat. J Ve Med Sci Belg. (2005) 67:617–9. doi: 10.1292/jvms.67.617
5.
BernabeAVallesNEchalecuMSGarrigosAAgutA. Tension pneumoperitoneum secondary to duodenal perforation presumptively due to the administration of meloxicam in a cat. Vet Rec Case Rep. (2021) 9: e40–4. doi: 10.1002/vrc2.40
6.
ChanSYKirschCMJensenWASherckJJoseS. Alerts, notices, and case reports tension pneumoperitoneum report of a case. West J Med. (1996) 165:61–4. PMID:
7.
OlindeAJCarpenterDMaherJM. Tension pneumoperitoneum a cause of acute aortic occlusion. Arch Surg. (1983) 118:1347–50. doi: 10.1001/archsurg.1983.01390110089020
8.
HamelPESSternAWGrossoFV. Gastric perforation in a dog: postmortem computed tomography and forensic autopsy findings. Forensic. Imaging. (2020) 20:200359. doi: 10.1016/j.fri.2020.200359
9.
HintonLEMcloughlinMAJohnsonSEWeisbrodeSE. Spontaneous gastroduodenal perforation in 16 dogs and seven cats(1982-1999). J Am Anim Hosp Assoc. (2002) 38:176–87. doi: 10.5326/0380176
10.
ParrahJDMoulviBAGaziMAMakhdoomiDMAtharHDarSet al. Gastric ulceration in dog: a review. Vet World. (2013) 6:449–54. doi: 10.5455/vetworld.2013.449-454
11.
OhkuraYLeeSKajiDOtaYHarutaSTakejiYet al. Spontaneous perforation of primary gastric malignant lymphoma: a case report and review of the literature. World J Surg Oncol. (2015) 13:35. doi: 10.1186/s12957-015-0458-0
12.
IgnjatovicNStojanovDDjordjevicMIgnjatovicJStojanovDBMilojkovicB. Perforation of gastric cancer-what should the surgeon do?Bosn J Basic Med Sci. (2016) 16:222–6. doi: 10.17305/BJBMS.2016.1020
13.
ChiuYHChenJDTiuCMChouYHYenDHTHuangCIet al. Reappraisal of radiographic signs of pneumoperitoneum at emergency department. Am J Emerg Med. (2009) 27:320–7. doi: 10.1016/j.ajem.2008.03.004
14.
GrassiRRomanoSPintoARomanoL. Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients. Eur J Radiol. (2004) 50:30–6. doi: 10.1016/j.ejrad.2003.11.012
15.
RagetlyGRBennettDRARagetlyCA. Septic peritonitis: etiology, pathophysiology, and diagnosis. Compend Contin Educ Vet. (2011) 33:E1–6. PMID:
16.
SungHKSangSSYongYJSukHHJinWKHeoungKK. Gastrointestinal tract perforation: MDCT findings according to the perforation sites. Korean J Radiol. (2009) 10:63–70. doi: 10.3348/kjr.2009.10.1.63
17.
BoysenSRTidwellASPenninckDG. Ultrasonographic findings in dogs and cats with gastrointestinal perforation. Vet Radiol Ultrasound. (2003) 44:556–64. doi: 10.1111/j.1740-8261.2003.tb00507.x
18.
BonczynskiJJLudwigLLBartonLJLoarAPetersonME. Comparison of peritoneal fluid and peripheral blood pH, bicarbonate, glucose, and lactate concentration as a diagnostic tool for septic peritonitis in dogs and cats. Vet Surg. (2003) 32:161–6. doi: 10.1053/jvet.2003.50005
Summary
Keywords
computed tomography, dog, gastric perforation, radiography, tension pneumoperitoneum
Citation
Kim M, Jeong J, Cho C, Eom K and Kim J (2024) Case report: Radiography and computed tomography of tension pneumoperitoneum caused by gastric perforation in a dog. Front. Vet. Sci. 10:1281966. doi: 10.3389/fvets.2023.1281966
Received
23 August 2023
Accepted
27 December 2023
Published
11 January 2024
Volume
10 - 2023
Edited by
Angela Marolf, The Ohio State University, United States
Reviewed by
Francisco Ruben Carvallo Chaigneau, Virginia Tech, United States; Teruo Itoh, Aoba Animal Hospital, Japan
Updates
Copyright
© 2024 Kim, Jeong, Cho, Eom and Kim.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jaehwan Kim, jaehwan@konkuk.ac.kr
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.