Frontiers in Molecular Biosciences

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Featured Research Topic: EUSM 2026

Our new Research Topic, 'EUSM 2026 - Highlighting early career researchers in Metabolomics’ is now open for summaries and manuscripts. The collection is in collaboration with the EUSM summer school and is intended for submissions from all EUSM attendees.

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Thank you EUSM

Thank you to the European School of Metabolomics (EUSM) for having us at your recent summer school. It was a pleasure to interact with so many talented students working in the field, and we look forward to supporting them in an Open Access space

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Frontiers in Molecular Biosciences

Submit your research

Author guidelines

Editor guidelines

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Get in touch with us about sponsorships

Featured Research Topic: EUSM 2026

Thank you SynBioBeta

Thank you EUSM

Editors

cecilia giulivi

jean baum

matteo becatti

mikhail bogdanov

Articles

Metabolic reprogramming-related drug resistance in Osteosarcoma: From molecular mechanisms to therapeutic translation

Editorial: Advances in gut microbiota, metabolites and the metabolic disorders

Editorial: EGFR-Targeted Therapy in Lung Cancer: Unraveling Molecular Regulation, Overcoming Resistance, and Advancing Precision Clinical Practice

Recent advances in research on high-frequency mutations in the ATP7B gene associated with Wilson disease in the Chinese population: from genetic evolution to precision medicine

Cellular Biochemistry

Modulation of oxidative stress and metabolic burden in papillary thyroid cancer by SGLT2 and broad DPP inhibition

Circulating exosomal miRNA in acute coronary syndrome: mechanisms, clinical relevance and future directions

Current insights into PHF14: Molecular Features and Functional Roles

Editorial: Molecular perspectives on host-pathogen interactions in immune evasion, viral replication, and pathogenesis

Differential correlations of serum PFASs with thyroid hormones in girls with central and incomplete precocious puberty: a machine learning analysis

Exploring the toxicity of extracts, fractions, and their bioactive components from raw and roasted sea buckthorn seeds on selected human cells

Discovery and validation of programmed cell death–associated key biomarker genes in ischemic stroke via ssGSEA/WGCNA and LASSO–SVM-RFE

Regulation of mechanical intercellular junctions and components of the mitochondrial electron transport chain and the TCA cycle in the hypertrophic heart by pyridostigmine or trandolapril

Itraconazole induced ferroptosis in acute myeloid leukemia cells through TP53INP1

Molecular mechanisms underlying fetal bovine serum-induced developmental delay in mouse embryos: a data-independent acquisition (DIA)-based proteomics study

Pathophysiological Mechanisms of Benign Prostatic Obstruction in Men with Small Prostate Volume and the Emerging Role of Ultra-Minimally Invasive Prostatic Urethral Dilation: A Narrative Review

In vitro antioxidant and collagen restoration activities of a standardized Centella asiatica L. extract formulated with phospholipids

Coagulopathy in viral haemorrhagic fevers and beyond: molecular mechanisms and targeted interventions

Growth-rate analysis of clathrin assembly: inferring endocytic kinetics in living cells and tissues

Various parts of Caricapapaya L. - the cardioprotective potential and prospects for pharmacological use

The role of gut microbiota dysbiosis in the pathogenesis of hyperuricemic nephropathy

Molecular Diagnostics and Therapeutics

Editorial: EGFR-Targeted Therapy in Lung Cancer: Unraveling Molecular Regulation, Overcoming Resistance, and Advancing Precision Clinical Practice

Recent advances in research on high-frequency mutations in the ATP7B gene associated with Wilson disease in the Chinese population: from genetic evolution to precision medicine

Spectroscopic and calorimetric analysis of the interaction between 9-hydroxy-5-methyl-12(H)-quino[3,4-b][1,4] benzothiazinium chloride with potential anticancer activity and main carrier plasma proteins. In vitro studies

Transcriptome sequencing and validation of potential biomarkers associated with cognitive impairment after hypertensive intracerebral hemorrhage

Development and evaluation of explainable machine learning models for predicting prognosis in patients with primary biliary cholangitis

Heterogeneity and molecular typing characteristics of mast cells in rheumatoid arthritis

LUHMES-derived 3D organoids as an enhanced platform for modelling dopaminergic neurodegeneration in Parkinson's disease

Regulatory T Cells in the Bladder Cancer Tumor Microenvironment: Mechanisms of Immune Suppression and Therapeutic Opportunities

Crucial role of telomere maintenance-related genes in survival prediction and subtype identification in colorectal cancer

Profiling miRNA in salivary samples from subjects with endometriosis: a pilot study

Predictive value of insulin resistance related indicators for osteoporosis risk in patients with type 2 diabetes mellitus: a real-world study

Microglia-neuron Communication in Ischemic Stroke: From Homeostatic Signaling to Pathological Remodeling and Therapeutic Targeting

EMCN Is Associated with Vascular-Immune Crosstalk and Represents a Potential Biomarker in Lung Adenocarcinoma

Lactylation in Sepsis-Associated Acute Kidney Injury: Regulatory Mechanisms and Therapeutic Prospects

Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at IL1A to fight SASP in senescent macrophages

Unravelling Therapeutic Resistance: Role of Cancer Stem Cell and MicroRNA in Metastatic Prostate Cancer

Structural Biology, Biophysics and Evolution

Editorial: Advances in protein structure biology – use of AI and beyond

CHCHD3(MIC19): mitochondrial cristae structure regulation and disease associations

Site-specific evaluation of mutation-based mimics of histone glycation in the nucleosome

Addressing convergence in the emerging era of structural phylogenetics

Analysis of proteins by a radical-free and highly reducing method of two-dimensional polyacrylamide gel electrophoresis

Protein structure prediction powered by artificial intelligence: from biochemical foundations to practical applications

Homage to James Feeney, a pioneer of biological NMR – Part I

Homage to James Feeney, a pioneer of biological NMR – Part II

Purification of ribosomes from human embryonic stem (hES) cells for high-resolution Cryo-EM structural studies

ATP-sensitive peptide-based coacervates for intracellular delivery of therapeutic oligonucleotides

Connecting the dots: deep learning-based automated model building methods in cryo-EM

Reformulation of the protein databank for real-time search of geometrical attributes of protein structures

TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis

Recent progress in human telomerase structure and its therapeutic targeting

Identification of lysozyme in Venetin-1 nanoparticle from the coelomic fluid of the earthworm Dendrobaena veneta

A DNA2 mutation in the ATP-binding motif identified in a diagnostically unresolved individual

Metabolomics

Metabolic reprogramming-related drug resistance in Osteosarcoma: From molecular mechanisms to therapeutic translation

Editorial: Advances in gut microbiota, metabolites and the metabolic disorders

Geographic Authentication of Premium Tobacco Extracts Using Machine Learning Models Trained on LC-HRMS Fingerprints

Cross-Model Metabolomic Signatures of Dietary Anti-Inflammatory (Poly)phenols in Nutraceutical Development: A Systematic Review

Editorial: Advances in mass spectrometry: transforming analytical chemistry in molecular and spatial biology, multimodal omics, and bioanalysis

Metabolites associated with the inclusion of atlantic GRO® seaweed supplementation as a methane mitigation strategy in the diet of replacement beef heifers