Frontiers in Aging Neuroscience

Hypothesis and Theory

Published on 28 Nov 2025

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

in Alzheimer's Disease and Related Dementias

Tommaso Costa
Donato Liloia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708234

1,077 views
1 citation

Original Research

Published on 28 Nov 2025

Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis

in Neuroinflammation and Neuropathy

Dewang Gao
Jiayu Lv
Xinhui Li
Wen Yong
Wenlong Yu
Lu Wang
Shangjia Ma
Hua Li
Shuaiqiang Zhang
Zi Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667025

1,056 views

Brief Research Report

Published on 27 Nov 2025

Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration

in Alzheimer's Disease and Related Dementias

Luca Sacchi
Marina Arcaro
Giorgio Bocca
Lia Schmid
Tiziana Carandini
Laura Ghezzi
Manuela Pintus
Anna Margherita Pietroboni
Chiara Fenoglio
Maria Serpente

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688996

1,474 views

Original Research

Published on 27 Nov 2025

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer’s disease mouse model: a pilot study

in Alzheimer's Disease and Related Dementias

Eun Ho Kim
Yoon-Jin Lee
Yong Suk Moon
Oh Dae Kwon
Dong Rak Kwon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1689593

1,196 views

Original Research

Published on 26 Nov 2025

Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations

in Parkinson’s Disease and Aging-related Movement Disorders

Vinod Metta
Anjana Soorajkumar
Tom Loney
Nasna Nassir
K. Ray Chaudhuri
Mohammed Jashim Uddin
Hani T. S. Benamer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676115

1,006 views

Review

Published on 26 Nov 2025

Unvalidated efficacy and significant risks hinder clinical use of deep cervical lymphatic-venous anastomosis for Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Rui Zhang
Ying Ying Liu
Xun Xia
Xinjun Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1671741

1,878 views

Original Research

Published on 26 Nov 2025

Clinical and neuropsychological features associated with progression in subjective cognitive decline

in Alzheimer's Disease and Related Dementias

Rafael Villino-Rodríguez
Mirla M. Ríos-Rivera
Genoveva Montoya-Murillo
Jonathan Patricio Baldera
Salomón Salazar-Londoño
María Cruz Rodríguez-Oroz
Miguel Germán Borda
Adolfo Jiménez-Huete
Mario Riverol

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1680762

1,351 views

Original Research

Published on 26 Nov 2025

Primitive reflexes as behavioral biomarkers of cognitive aging: associations with physical activity and resilience—a pilot study

in Neurocognitive Aging and Behavior

Anna Horváth-Pápai
Eliza Eszter Tóth
István Barthalos
Zoltán Alföldi
Johanna Takács
Ferenc Ihász

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1687512

1,344 views

Original Research

Published on 25 Nov 2025

VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model

in Parkinson’s Disease and Aging-related Movement Disorders

Mei Jiang
Xu Deng
Zijie Qiu
Yuan Fu
Zixiong Qiu
Jiankai Zhang
Hongxia Fu
Jie Li
Yao Luo
Xiaojun Cui

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692687

1,389 views

Original Research

Published on 25 Nov 2025

Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum

in Parkinson’s Disease and Aging-related Movement Disorders

Chenxi Pan
Enchun Zhao
Jingru Ren
Gaiyan Zhou
Yajie Wang
Ronggui Zhang
Yang Shen
Weiguo Liu
Jiu Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1685244

982 views

Original Research

Published on 24 Nov 2025

Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study

in Alzheimer's Disease and Related Dementias

Unai Torres
David Bernal
Ibai Gurrutxaga
Ainara Estanga
Pablo Martínez-Lage
Olatz Arbelaitz

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1653074

1,433 views

Original Research

Published on 24 Nov 2025

Music-induced physiological markers for detecting Alzheimer's disease using machine learning

in Alzheimer's Disease and Related Dementias

Rodrigo Lima
Gonçalo Barradas
Sergi Bermúdez i Badia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701970

1,078 views

Review

Published on 21 Nov 2025

Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration

in Parkinson’s Disease and Aging-related Movement Disorders

Chang Liu
Wei He
JianHua Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678460

2,122 views

Original Research

Published on 20 Nov 2025

Is cognitive reserve associated with cognitive function across stroke severity? A longitudinal study among Chinese stroke patients

in Neurocognitive Aging and Behavior

Yinuo Ou
Yanrong Zhang
Yalin Lv
Silian Ding
Xiangjing Kong
Hanzhang Xu
Bei Wu
Hui Wei
Juan Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1652238

1,227 views

Correction

Published on 19 Nov 2025

Correction: Neuroimaging insights into lung disease-related brain changes: from structure to function

in Neurocognitive Aging and Behavior

Zhixi Zhang
Miao He
Yubo Liu
Zhongtian Guan
Chunlin Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1738176

743 views
1 citation

Original Research

Published on 19 Nov 2025

Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies

in Parkinson’s Disease and Aging-related Movement Disorders

Zhou Su
Jun Kuai
Tingting Yi
Hao Wu
Jinghuan Gan
Zhihong Shi
Shuai Liu
Yong Ji

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637930

1,258 views

Mini Review

Published on 19 Nov 2025

Neuroimmune dynamics and brain aging: mechanisms and consequences

in Cellular and Molecular Mechanisms of Brain-aging

Ludmila Müller
Svetlana Di Benedetto
Viktor Müller

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1715045

2,178 views
3 citations

Original Research

Published on 19 Nov 2025

MRI-derived global small vessel disease burden serves as a marker of hippocampal sclerosis and clinical stage across the probable Alzheimer’s disease continuum

in Alzheimer's Disease and Related Dementias

Ya-Che Chen
Ting-Bin Chen
Hsin-Chieh Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692747

1,879 views

Original Research

Published on 19 Nov 2025

Singing for memory: neural and cognitive effects of a choral intervention in older adults

in Neurocognitive Aging and Behavior

Miriam Napadow
Håkan Fischer
Maria Sandgren
Máté Magyar
Zsuzsanna Lénárd
László Harmat
Örjan de Manzano

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679873

3,005 views

Original Research

Published on 19 Nov 2025

Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose/AlCl3

in Cellular and Molecular Mechanisms of Brain-aging

Shreshta Jain
Divya Vohora

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676926

1,958 views

Original Research

Published on 19 Nov 2025

Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study

in Alzheimer's Disease and Related Dementias

Zhou Su
Mengran Liu
Jun Kuai
Tingting Yi
Yuechang Zheng
Xinran Bao
Jiyu Ji

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1630826

1,037 views

Original Research

Published on 19 Nov 2025

Vitamin D-linked vulnerability and functional connectivity alterations in the superior frontal gyrus contributing to cognitive impairment in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Lingling Lv
Lixia Qin
Shenglan Hu
Changlian Tan
Haiyan Liao
Hainan Zhang
Feng Ren
Chunyu Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657723

1,312 views

Original Research

Published on 17 Nov 2025

Mediating role of muscle quality in the liver–brain axis: integrated analysis of CT markers of body composition, brain aging, and biomarkers

in Neuroinflammation and Neuropathy

Minchul Kim
Chongwon Pae
Joon Ho Moon
Inpyeong Hwang
Kyu Sung Choi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676721

1,821 views

Correction

Published on 17 Nov 2025

Correction: Current application status of non-invasive brain stimulation techniques in Alzheimer's disease: a bibliometric analysis

in Alzheimer's Disease and Related Dementias

Shan Cong
Meng Wang
Long Yan
Li Sun
Bowen Zheng
Jinying Xie
Tao Yu
Yulin Qian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730649

1,212 views
1 citation

7,799 articles

articles

Are current etiological theories of Alzheimer’s disease falsifiable? An epistemological assessment

Association of white matter hyperintensity with systemic inflammation markers and cognitive assessments: a cross-sectional study via SHAP analysis

Association between Klotho levels in cerebrospinal fluid and choroid plexus enlargement in neurodegeneration

Evaluation of microcurrent as an adjunct to donepezil therapy in an Alzheimer’s disease mouse model: a pilot study

Absence of the LRRK2 mutation in Emirati Parkinson’s disease patients in contrast to other Arab populations

Unvalidated efficacy and significant risks hinder clinical use of deep cervical lymphatic-venous anastomosis for Alzheimer’s disease

Clinical and neuropsychological features associated with progression in subjective cognitive decline

Primitive reflexes as behavioral biomarkers of cognitive aging: associations with physical activity and resilience—a pilot study

VPS35 D620N mutation impairs neurogenesis and promotes ferroptosis in Parkinson’s disease by using molecular docking, molecular dynamic simulation, and cellular model

Multimodal MRI reveals distinct hippocampal subregional alterations in de novo Parkinson’s disease across the cognitive spectrum

Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study

Music-induced physiological markers for detecting Alzheimer's disease using machine learning

Exercise regulates mitophagy to alleviate parkinsonian neurodegeneration

Is cognitive reserve associated with cognitive function across stroke severity? A longitudinal study among Chinese stroke patients

Correction: Neuroimaging insights into lung disease-related brain changes: from structure to function

Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies

Neuroimmune dynamics and brain aging: mechanisms and consequences

MRI-derived global small vessel disease burden serves as a marker of hippocampal sclerosis and clinical stage across the probable Alzheimer’s disease continuum

Singing for memory: neural and cognitive effects of a choral intervention in older adults

Decanoic acid, an MCT dietary component, alleviates cognitive impairment, cellular senescence, and promotes autophagy in accelerated aging and neurotoxic mouse models induced by chronic administration of D-galactose and D-galactose/AlCl3

Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study

Vitamin D-linked vulnerability and functional connectivity alterations in the superior frontal gyrus contributing to cognitive impairment in Parkinson’s disease

Mediating role of muscle quality in the liver–brain axis: integrated analysis of CT markers of body composition, brain aging, and biomarkers

Correction: Current application status of non-invasive brain stimulation techniques in Alzheimer's disease: a bibliometric analysis