Frontiers in Aging Neuroscience

Original Research

Published on 07 Apr 2025

Substantia nigra and blood gene signatures and biomarkers for Parkinson’s disease from integrated multicenter microarray-based transcriptomic analyses

in Parkinson’s Disease and Aging-related Movement Disorders

Hui-Hui Fan
Na-Na Hou
Dao-Lu Zhang
Dan-Ni Liu
Rong-Ting Tang
Hai-Tao Luo
Ya-Dan Song
Lei Cui
Xiong Zhang
Jian-Hong Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540830

931 views

Original Research

Published on 07 Apr 2025

Calcineurin-mediated regulation of growth-associated protein 43 is essential for neurite and synapse formation and protects against α-synuclein-induced degeneration

in Alzheimer's Disease and Related Dementias

Ekaterina Grebenik
Sofia Zaichick
Gabriela Caraveo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566465

1,015 views

Original Research

Published on 04 Apr 2025

Exploring the link between estimated glucose disposal rate and Parkinson’s disease: cross-sectional and mortality analysis of NHANES 2003–2016

in Parkinson’s Disease and Aging-related Movement Disorders

Xiaoting Li
Zhaohao Zeng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1548020

1,517 views

Review

Published on 04 Apr 2025

Aerobic exercise, an effective intervention for cognitive impairment after ischemic stroke

in Neurocognitive Aging and Behavior

Mingjin Zhu
Wenjun Chen
Jie Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1514271

1,768 views

Original Research

Published on 04 Apr 2025

Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway

in Parkinson’s Disease and Aging-related Movement Disorders

Liping Huang
Qiaofeng Li
Jingyi Wu
Yingying He
Junwei Huang
Sipeng Xie
Canfeng Yang
Qingling Ruan
Zhongliu Zhou
Minzhen Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1568002

1,500 views

Original Research

Published on 03 Apr 2025

Mapping the scientific research on exercise therapy for Alzheimer’s disease: a scientometric study of hotspots and emerging trends

in Alzheimer's Disease and Related Dementias

Shi Long Song
Wen Bing Yu
Xin Min Cai
Jie Ma
Lu Lu Zou
Li Li Gao
Shi Ming Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1536515

1,823 views

Original Research

Published on 03 Apr 2025

Lifetime estrogen exposure and domain-specific cognitive performance: results from the IGNITE study

in Neurocognitive Aging and Behavior

Amber Watts
Shannon Donofry
Hayley Ripperger
Nicole M. Eklund
Lu Wan
Chaeryon Kang
George Grove
Lauren E. Oberlin
Swathi Gujral
Eric D. Vidoni

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1524474

1,483 views

Original Research

Published on 02 Apr 2025

Evaluation of the efficacy of Tai Chi on the cognitive function of patients with mild cognitive dysfunction and research on its mechanism

in Neurocognitive Aging and Behavior

Lin Lin
Yao-Xi He
Quan Wen
Jia-Yang Liu
Yu Dai
Yu-Zhe Fei
Hang Li
Chang-Qing Li
Huan Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1435996

1,452 views

Original Research

Published on 02 Apr 2025

Synapses-associated research in Parkinson’s disease: an explored trends analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1537119

1,179 views

Original Research

Accepted on 01 Apr 2025

Cerebral pulsatility might be a driver of neurofunctional reorganization in the aging brain: An MRI and NIRS Study

in Neurocognitive Aging and Behavior

Hanieh Mohammadi
Parikshat Sirpal
Louis Bherer
Frederic Lesage
Yves Joanette

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1486775

178 views

Original Research

Published on 31 Mar 2025

Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study

in Alzheimer's Disease and Related Dementias

Cassandre Palix
Léa Chauveau
Francesca Felisatti
Anne Chocat
Laurent Coulbault
Oriane Hébert
Florence Mézenge
Brigitte Landeau
Sacha Haudry
Séverine Fauvel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1508677

1,338 views

Original Research

Published on 31 Mar 2025

Serine-129 phosphorylated α-synuclein drives mitochondrial dysfunction and calcium dysregulation in Parkinson’s disease model

in Neurocognitive Aging and Behavior

Jie Jiao
Weijin Liu
Ge Gao
Hui Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1538166

1,944 views

Original Research

Published on 28 Mar 2025

Age-related hearing loss associated with cognitive impairment in the Polish cohort of the PURE study

in Neurocognitive Aging and Behavior

Katarzyna Połtyn-Zaradna
Katarzyna Pazdro-Zastawny
Dorota Szcześniak
Alicja Basiak-Rasała
Maria Wołyniec
Katarzyna Zatońska
Tomasz Zatoński

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540803

1,434 views

Original Research

Published on 28 Mar 2025

Higher dietary butyrate intake is associated with better cognitive function in older adults: evidence from a cross-sectional study

in Alzheimer's Disease and Related Dementias

Jiayu Tu
Jun Zhang
Gang Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522498

2,294 views

Original Research

Published on 28 Mar 2025

Neural network localization in Parkinson’s disease with impulse control disorders

in Parkinson’s Disease and Aging-related Movement Disorders

Hucheng Yang
Siyu Gu
Haihua Sun
Fengmei Zhang
Zhenyu Dai
Pinglei Pan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549589

1,359 views

Review

Published on 27 Mar 2025

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression

in Alzheimer's Disease and Related Dementias

Cong He
Baojiang Chen
Hecai Yang
Xiaoqing Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1554398

2,671 views