Frontiers in Aging Neuroscience

Original Research

Published on 22 Apr 2025

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

in Alzheimer's Disease and Related Dementias

Lingjing Zhang
Yanwei Wang
Yuming Liu
Zi Ye
Zhaohui Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1492804

3,707 views
1 citation

Original Research

Published on 22 Apr 2025

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

in Alzheimer's Disease and Related Dementias

Li Zhao
Lingyun Liu
Miao Lin
Linyun Xie
Hui Hong
Qingze Zeng
Shuyue Wang
Ruiting Zhang
Zhenhua Zhao
Peiyu Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549072

4,098 views

Original Research

Published on 22 Apr 2025

Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease

in Neurocognitive Aging and Behavior

Han Liu
Wenhui Zheng
Jie Geng
Xia Zhou
Yu Xia
Yan Liu
Gang Zhang
Xiaoqun Zhu
Daping Lv
Zhongwu Sun

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1538850

3,161 views
1 citation

Systematic Review

Published on 22 Apr 2025

Comparative efficacy of rTMS on different targets in Alzheimer’s disease: a systematic review and meta-analysis

in Neurocognitive Aging and Behavior

Yushu Zhang
Ke Dong
Jiajia Yang
Qifan Guo
Yan Zhao
Xiaoxia Zhu
Dongxu Liu
Peng Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1536573

5,367 views
3 citations

Original Research

Published on 17 Apr 2025

Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

in Parkinson’s Disease and Aging-related Movement Disorders

Fei Huang
Jingwen Hao
Chanjuan Chen
Qun Liu
Dan He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1510654

3,990 views

Original Research

Published on 16 Apr 2025

The impact of BST1 rs4698412 variant on Parkinson’s disease progression in a longitudinal study

in Parkinson’s Disease and Aging-related Movement Disorders

Hao-Ling Xu
Yu Yang
Li-Na Chen
Yun-Jing Li
Guo-En Cai
Ying-Qing Wang
Yan-Hong Weng
Xiao-Ling Lin
Jing Jian
Xiao-Chun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1570347

2,809 views
1 citation

Editorial

Published on 16 Apr 2025

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

in Cellular and Molecular Mechanisms of Brain-aging

Anamaria Jurcau

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1602391

2,116 views

Original Research

Published on 16 Apr 2025

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

in Alzheimer's Disease and Related Dementias

Huan Chen
Fangzhen Guo
Yan Zhao
Wei Liu
Bingyu Chen
Chang Wang
Lining Huang
Sufang Jiang
Xiaowei Ma
Huiling Ren

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1572976

4,029 views
2 citations

Correction

Published on 16 Apr 2025

Corrigendum: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults

in Neurocognitive Aging and Behavior

Javier Oltra
Grégoria Kalpouzos
Ingrid Ekström
Maria Larsson
Yuanjing Li
Chengxuan Qiu
Erika J. Laukka

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599273

2,332 views

Methods

Published on 15 Apr 2025

The innovation and practice of the “hand as foot” teaching method in the teaching of Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Jingjing Yang
Dandan Yang
Jie Yu
Jiahui Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1519067

2,326 views
1 citation

Original Research

Published on 15 Apr 2025

Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset

in Parkinson’s Disease and Aging-related Movement Disorders

Tianqi Xu
Zhihuai Deng
Yinhui Yu
Wenchao Duan
Zeyu Ma
Haoran Liu
Lianling Li
Moxuan Zhang
Siyu Zhou
Pengda Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1564754

3,549 views
1 citation

Original Research

Published on 15 Apr 2025

Decoding immune cell dynamics in ischemic stroke: insights from single-cell RNA sequencing analysis

in Neuroinflammation and Neuropathy

Yating Lan
Chun Zou
Feiyu Nong
Qi Huang
Jingyi Zeng
Wenyi Song
Guining Liang
Qingyan Wei
Mika Pan
Donghua Zou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549518

4,600 views
1 citation

Original Research

Published on 15 Apr 2025

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors

in Alzheimer's Disease and Related Dementias

Alexandre Guimarães de Almeida Barros
Thayana Oliveira Soares
Ariane Flávia Almeida Lage
Marco Túlio Gualberto Cintra
Jonas Jardim de Paula
Olívio Brito Malheiro
Antonio Eiras Falcão
Christiano Altamiro Coli Nogueira
Leandro Braz de Carvalho
Marco Aurélio Romano Silva

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1557016

2,756 views

Original Research

Published on 14 Apr 2025

Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014

in Neurocognitive Aging and Behavior

Fan Wang
Xiangyang Wang
Chaowei Wang
Hao Liu
Zhixiu Xu
Dongli Li
Xiaowen Zhao
Jialu Zhao
Shaomin Li
Jianhua Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571159

3,560 views
1 citation

Original Research

Published on 14 Apr 2025

Cerebrospinal fluid levels of tumour necrosis factor-α and its receptors are not associated with disease progression in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Manal Aljuhani

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547185

2,054 views
1 citation

Original Research

Published on 14 Apr 2025

Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China

in Neurocognitive Aging and Behavior

Qingyue Wu
Jingyuan Yang
Xunqiong Zhou
Mingyan Chen
Xing Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1489033

2,323 views

Systematic Review

Published on 14 Apr 2025

Meta-analysis of the effects of multi-component exercise on cognitive function in older adults with cognitive impairment

in Neurocognitive Aging and Behavior

Hualei Liu
Zhiyuan Sun
Haiqing Zeng
Jincheng Han
Mengqi Hu
Dewei Mao
Xuewen Tian
Ran Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1551877

7,675 views
10 citations

Original Research

Published on 11 Apr 2025

Uncovering unseen ties: a network analysis explores activities of daily living limitations and depression among Chinese older adults

in Neurocognitive Aging and Behavior

Hongbo Sun
Youcai Zhou
Xianqiang Zhang
Zhongxin Liang
Jinlan Chen
Ping Zhou
Xinjie Xue

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1527774

4,314 views
1 citation

Original Research

Published on 11 Apr 2025

Normative characterization of age-related periodic and aperiodic activity in resting-state real-world clinical EEG recordings

in Neurocognitive Aging and Behavior

Sophie Leroy
Viktor Bublitz
Falk von Dincklage
Daria Antonenko
Robert Fleischmann

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540040

3,104 views
8 citations

Original Research

Published on 11 Apr 2025

Bundled assessment to replace on-road test on driving function in stroke patients: a binary classification model via random forest

in Neurocognitive Aging and Behavior

Lu Huang
Xin Liu
Jiang Yi
Yu-Wei Jiao
Tian-Qi Zhang
Guang-Yao Zhu
Shu-Yue Yu
Zhong-Liang Liu
Min Gao
Xiao-Qin Duan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1503672

2,082 views
1 citation

Original Research

Published on 11 Apr 2025

Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism

in Neurocognitive Aging and Behavior

Ronghua Ling
Xingxing Cen
Shaoyou Wu
Min Wang
Ying Zhang
Juanjuan Jiang
Jiaying Lu
Yingqian Liu
Chuantao Zuo
Jiehui Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1580910

3,920 views
3 citations

Original Research

Published on 11 Apr 2025

Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation

in Neurocognitive Aging and Behavior

Meixi Li
Jiaxi Song
Xiaoli Niu
Feng Mo
Xiaohua Xie
Xiuqin Li
Yu Yin
Tianjun Wang
Xiujuan Song
Jingze Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1521353

2,724 views
1 citation

Systematic Review

Published on 10 Apr 2025

Frontotemporal dementia: a systematic review of artificial intelligence approaches in differential diagnosis

in Alzheimer's Disease and Related Dementias

Serena Dattola
Augusto Ielo
Giuseppe Varone
Alberto Cacciola
Angelo Quartarone
Lilla Bonanno

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547727

7,588 views
5 citations

Correction

Published on 09 Apr 2025

Corrigendum: Boosting antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in parkinsonian brain via an Nrf2-driven Wnt/β-catenin prosurvival axis

in Parkinson’s Disease and Aging-related Movement Disorders

Maria Francesca Serapide
Francesca L'Episcopo
Cataldo Tirolo
Nunzio Testa
Salvatore Caniglia
Carmela Giachino
Bianca Marchetti

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1596878

1,210 views

7,815 articles

articles

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease

Comparative efficacy of rTMS on different targets in Alzheimer’s disease: a systematic review and meta-analysis

Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

The impact of BST1 rs4698412 variant on Parkinson’s disease progression in a longitudinal study

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Corrigendum: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults

The innovation and practice of the “hand as foot” teaching method in the teaching of Parkinson’s disease

Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset

Decoding immune cell dynamics in ischemic stroke: insights from single-cell RNA sequencing analysis

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors

Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014

Cerebrospinal fluid levels of tumour necrosis factor-α and its receptors are not associated with disease progression in Alzheimer’s disease

Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China

Meta-analysis of the effects of multi-component exercise on cognitive function in older adults with cognitive impairment

Uncovering unseen ties: a network analysis explores activities of daily living limitations and depression among Chinese older adults

Normative characterization of age-related periodic and aperiodic activity in resting-state real-world clinical EEG recordings

Bundled assessment to replace on-road test on driving function in stroke patients: a binary classification model via random forest

Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism

Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation

Frontotemporal dementia: a systematic review of artificial intelligence approaches in differential diagnosis

Corrigendum: Boosting antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in parkinsonian brain via an Nrf2-driven Wnt/β-catenin prosurvival axis

articles

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease

Comparative efficacy of rTMS on different targets in Alzheimer’s disease: a systematic review and meta-analysis

Reduced composite dietary antioxidant index increases the risk of Parkinson’s disease and all-cause mortality in Parkinson’s disease patients: evidence from the NHANES database

The impact of BST1 rs4698412 variant on Parkinson’s disease progression in a longitudinal study

Editorial: Similarities and differences between cellular and molecular mechanisms of normal brain aging and neurodegeneration

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Corrigendum: Cerebrovascular burden and neurodegeneration linked to 15-year odor identification decline in older adults

The innovation and practice of the “hand as foot” teaching method in the teaching of Parkinson’s disease

Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset

Decoding immune cell dynamics in ischemic stroke: insights from single-cell RNA sequencing analysis

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors

Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014

Cerebrospinal fluid levels of tumour necrosis factor-α and its receptors are not associated with disease progression in Alzheimer’s disease

Large inter-arm systolic blood pressure difference is associated with cognitive impairment in older adults: a cross-sectional study in rural southwest China

Meta-analysis of the effects of multi-component exercise on cognitive function in older adults with cognitive impairment

Uncovering unseen ties: a network analysis explores activities of daily living limitations and depression among Chinese older adults

Normative characterization of age-related periodic and aperiodic activity in resting-state real-world clinical EEG recordings

Bundled assessment to replace on-road test on driving function in stroke patients: a binary classification model via random forest

Explainable graph neural network based on metabolic brain imaging for differential diagnosis of parkinsonism

Baicalein ameliorates cognitive decline induced by chronic cerebral hypoperfusion through the SIRT1-mediated Notch1 pathway to improve angiogenesis and suppress neuroinflammation

Frontotemporal dementia: a systematic review of artificial intelligence approaches in differential diagnosis

Corrigendum: Boosting antioxidant self-defenses by grafting astrocytes rejuvenates the aged microenvironment and mitigates nigrostriatal toxicity in parkinsonian brain via an Nrf2-driven Wnt/β-catenin prosurvival axis

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice