Frontiers in Aging Neuroscience

Original Research

Published on 09 Jan 2026

The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts

in Neuroinflammation and Neuropathy

Haining Zhang
Jiange Chen
Yuntian Ye
Hongyi Wang
Shun Fan
Wei Zhang
An Bao
Huanan Li
Jingui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1733007

970 views

Original Research

Published on 09 Jan 2026

Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease

in Parkinson’s Disease and Aging-related Movement Disorders

Zhen Hu
Jing-jin Wan
Qin-qin Yan
Yu Fan
Jun Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1735522

1,231 views

Original Research

Published on 09 Jan 2026

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

in Cellular and Molecular Mechanisms of Brain-aging

Ming Sun
Chao Wu
Jingjing Wu
Lixin Liu
Liang Gu
Zihao Wang
Xue Yang
Feng Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657523

1,044 views

Correction

Published on 08 Jan 2026

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

in Neurocognitive Aging and Behavior

Yu Wang
Li Wang
Yunhong Du
Xiaoye Ma
Lili Sun
Xiujie Zhang
Wenli Rong
Jianwei Li
Yao Shi
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1763134

730 views

Original Research

Published on 08 Jan 2026

Separating cognitive and motor contributions to iADL difficulties in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Rekha Ravikumar
Marta Statucka
Melanie Cohn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1732479

850 views

Original Research

Published on 08 Jan 2026

Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients

in Neuroinflammation and Neuropathy

Wenfei Liang
Jingling Zhu
Xiuling Yang
Xiaohua He
Guoshun Li
Zhaobang Chen
Jiasheng Zhao
Kangqiang Yang
Bin Liao
Huiquan Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1654146

934 views

Original Research

Published on 08 Jan 2026

Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes

in Alzheimer's Disease and Related Dementias

Joel Eyamu
Boncho Ku
Kahye Kim
Kun Ho Lee
Jaeuk U. Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675330

1,223 views

Original Research

Published on 07 Jan 2026

The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer’s disease: a resting-state fMRI study

in Alzheimer's Disease and Related Dementias

Benqin Liu
Chunbing Chen
Pan Cai
Jiaren Zhang
Li Yang
Xu Chen
Xuejin Ma
Xuetao Jiang
Anjie Zhang
Linfeng Song

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1716076

1,221 views

Original Research

Published on 06 Jan 2026

Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women

in Alzheimer's Disease and Related Dementias

Sheng-Min Wang
Chaiho Jeong
Yoo Hyun Um
Dong Woo Kang
Sunghwan Kim
Soyoung Lee
Chang Uk Lee
Howard J. Aizenstein
Ki-Hyun Baek
Hyun Kook Lim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1697255

1,245 views

Original Research

Published on 05 Jan 2026

Machine learning models for the prediction of levodopa response to tremor in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Fangfei Li
Shinuan Lin
Rui Yan
Yusha Cui
Kang Ren
Zhonglue Chen
Lingyan Ma
Tao Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1690155

1,073 views

Perspective

Published on 05 Jan 2026

AI agents in Alzheimer’s disease management: challenges and future directions

in Alzheimer's Disease and Related Dementias

Gerasimos Grammenos
Aristidis G. Vrahatis
Konstantinos Lazaros
Themis P. Exarchos
Panagiotis Vlamos
Marios G. Krokidis

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1735892

1,743 views

Original Research

Published on 05 Jan 2026

Factors associated with sleep disorders in elderly patients with Parkinson’s disease and cognitive impairment and the nomogram model development

in Parkinson’s Disease and Aging-related Movement Disorders

Yimei Zhang
Liyan Sun
Haitao Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670915

978 views

Original Research

Published on 05 Jan 2026

Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment

in Neurocognitive Aging and Behavior

Jiyue Qin
Carol A. Derby
Grace Liu
Cuiling Wang
Richard P. Sloan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1707771

1,235 views

Original Research

Published on 05 Jan 2026

Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants

in Neurocognitive Aging and Behavior

Yucheng Gu
Xiaoyuan Li
Nihong Chen
Feng Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708268

1,152 views

Original Research

Published on 02 Jan 2026

Quantity and quality of care and staff knowledge regarding people with Parkinson’s disease in long-term nursing care: “real-life” results from the German Care4PD study

in Parkinson’s Disease and Aging-related Movement Disorders

Odette Fründt
Verena Caroline Lamb
Anne-Marie Hanff
Tobias Mai
Christiane Kirchner
Ali Amouzandeh
Carsten Buhmann
Rejko Krüger
Alfons Schnitzler
Martin Südmeyer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701254

988 views

Original Research

Published on 31 Dec 2025

Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Qianyi Zheng
Dongling Zhang
Junyan Sun
Junling Wang
Lili Chen
Xuemei Wang
Tao Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1709735

1,777 views

Original Research

Published on 29 Dec 2025

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson’s disease and heart failure

in Parkinson’s Disease and Aging-related Movement Disorders

Zhen Ni
Gaoge Wang
Yingyan Li
Huan Chen
Hongwei Hou
Qingyuan Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1709337

1,295 views

Original Research

Published on 19 Dec 2025

Treadmill exercise alleviates Alzheimer’s disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming

in Alzheimer's Disease and Related Dementias

Fei Liang
Feng Sun
Cuijun Guo
Huacong Zhong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1734837

2,614 views

Original Research

Published on 18 Dec 2025

Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis

in Neurocognitive Aging and Behavior

Lei Wang
Hongjuan Liu
Xianfeng Meng
Zhengjiao Tuo
Yuning Zhou
Peiyi Wu
Enhui Wang
Yuxin Shen
Ziyi Wang
Caijiu Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1722050

1,085 views

Review

Published on 17 Dec 2025

The application of fecal microbiota transplantation in Parkinson’s disease

in Cellular and Molecular Mechanisms of Brain-aging

Boyan Wang
Di Ma
Na Li
Tianfei Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1713899

1,698 views

Review

Published on 17 Dec 2025

Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

in Neuroinflammation and Neuropathy

Yuliu Li
Yiqing Tan
Wei Zuo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1702993

871 views

Original Research

Published on 16 Dec 2025

Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus

in Neurocognitive Aging and Behavior

Xiaofeng Wang
Ziao Xu
Bohang Liu
Xuefei Ji
Liao Guan
Lei Ye
Hongwei Cheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672254

1,325 views

Original Research

Published on 16 Dec 2025

Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism

in Alzheimer's Disease and Related Dementias

Yitong Xiao
He Li
Xinyuan Han
Yixiao Liu
Jiayu Sun
Chenxi Sun
Yichen Wang
Tianyuan Ye
Xiaorui Cheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622286

1,256 views

Original Research

Published on 16 Dec 2025

A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment

in Parkinson’s Disease and Aging-related Movement Disorders

Xinchao Hu
Yu Liu
Yuan Cao
Chunli Wei
Kun Liu
Jing-Hua Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723169

1,512 views

7,799 articles

articles

The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts

Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Separating cognitive and motor contributions to iADL difficulties in Parkinson’s disease

Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients

Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes

The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer’s disease: a resting-state fMRI study

Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women

Machine learning models for the prediction of levodopa response to tremor in Parkinson’s disease

AI agents in Alzheimer’s disease management: challenges and future directions

Factors associated with sleep disorders in elderly patients with Parkinson’s disease and cognitive impairment and the nomogram model development

Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment

Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants

Quantity and quality of care and staff knowledge regarding people with Parkinson’s disease in long-term nursing care: “real-life” results from the German Care4PD study

Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson’s disease

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson’s disease and heart failure

Treadmill exercise alleviates Alzheimer’s disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming

Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis

The application of fecal microbiota transplantation in Parkinson’s disease

Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus

Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism

A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment