Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 06 Mar 2026

Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor

in Alzheimer's Disease and Related Dementias

Zhiming Zeng
Xin Jia
Shushu Han
Cuidie Zeng
Jing Bi
Lingchen Liu
Yueming Wu
Tengao Gao
Lei Liang
Fangxiao Cheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1733820

145 views

Study Protocol

Published on 05 Mar 2026

A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial

in Alzheimer's Disease and Related Dementias

Yuanbao Sun
Zhuorong Zi
Songli Wang
Minghui Weng
Jin Peng
Linwan Liu
Jian Zhou
Nianjie Wang
Bo Liu
Kezhi Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1721346

Original Research

Published on 05 Mar 2026

Deep learning for FDG-PET classification in patients with Alzheimer’s disease, dementia with Lewy bodies and their mixed pathology: a solution for diagnostic heterogeneity

in Alzheimer's Disease and Related Dementias

Seonggyu Kim
Seun Jeon
Kwonhwi Cho
Sungwoo Kang
Sungkyu Bang
Byoung Seok Ye
Jong-Min Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1780858

Review

Accepted on 04 Mar 2026

Intervention of Ginseng-Derived Macromolecular Drugs in Alzheimer's Disease: Exploring Mechanisms and Assessing Potential

in Alzheimer's Disease and Related Dementias

Weiqiao Liu
Yunfan Bai
Wenyi Qu
Xiaoying Zhang
Shuo Zhou
Haoming Luo
Ming Zhu
Dongyang Li
Xiaoxue Fang

Frontiers in Aging Neuroscience

Retraction

Accepted on 04 Mar 2026

Retraction: Corrigendum: Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus

in Alzheimer's Disease and Related Dementias

Frontiers Editorial Office

Frontiers in Aging Neuroscience

Retraction

Accepted on 04 Mar 2026

Retraction: Identification of cerebral metal ion imbalance in the brain of ageing Octodon degus

in Alzheimer's Disease and Related Dementias

Frontiers Editorial Office

Frontiers in Aging Neuroscience

Original Research

Published on 04 Mar 2026

TAS2R38 taster variants-linked MGAM expression in Alzheimer’s disease: a novel target for precision drug repurposing

in Alzheimer's Disease and Related Dementias

Claire W. Su
Kewei Chen
Teresa Wu
Eric M. Reiman
Qi Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1768436

175 views

Review

Published on 04 Mar 2026

Targeting the astrocytic metabolic cascade in Alzheimer’s disease: mechanisms, challenges and opportunities

in Alzheimer's Disease and Related Dementias

Huawen Cao
Junyi Liang
Xiaohong Dong
Zhiqi Xia
Xiaoting Luo
Bin Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1767811

Review

Published on 04 Mar 2026

Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication

in Alzheimer's Disease and Related Dementias

Rutong Wang
Yingqi Feng
Ziyu Zhou
Jiajun Jiang
Runze Zhang
Wenhui Zou
Haotian Yang
Wenbo Lv
Shen Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1748418

109 views

Original Research

Published on 04 Mar 2026

Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway

in Alzheimer's Disease and Related Dementias

Xianhui Huang
Jiajia Liu
Yanna Ren
Dingding Liu
Jing Cai
Liping Cao
Tong Lei
Yuanhua Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1719664

Review

Accepted on 03 Mar 2026

Glial Lactate Metabolism and Transport in Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Yaxin Wang
Boxiang Feng
Ruiwei Hong
Dan Qiu
Jinfeng Zhao
Li Zhao

Frontiers in Aging Neuroscience

Original Research

Published on 03 Mar 2026

Associations of anticholinergic burden of medication with cognitive decline and longitudinal brain atrophy in the Alzheimer’s disease spectrum

in Alzheimer's Disease and Related Dementias

Stefan Teipel
Alice Grazia
Oliver Peters
Josef Priller
Anja Schneider
Jens Wiltfang
Claudia Bartels
Björn Hendrik Schott
Frank Jessen
Emrah Duezel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1751326

278 views

Review

Accepted on 27 Feb 2026

Mitochondrial dysfunction in Alzheimer's Disease and Related Sex Differences

in Alzheimer's Disease and Related Dementias

Afzal Misrani
Conelius Ngwa
Fudong Liu

Frontiers in Aging Neuroscience

Original Research

Accepted on 27 Feb 2026

Dysregulated Glucose Metabolism in the Visual Cortex of Human Subjects with Mild Cognitive Impairment and Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Ulrik N Mjaaseth
Mingfo Hsu
Joseph Arballo
Fawaz Haj
Viharkumar Patel

Frontiers in Aging Neuroscience

Perspective

Published on 27 Feb 2026

Rethinking cervical deep lymphovenous anastomosis in Alzheimer’s disease: problems and prospects

in Alzheimer's Disease and Related Dementias

Gaiqing Wang
Haiyan Li
Sen Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1722759

296 views

Review

Accepted on 26 Feb 2026

Molecular Mechanisms Underlying Exercise-Enhanced Autophagy in Improving Neuroplasticity in Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Qian Li
Renqing Zhao
Xin Tian
Haocheng Xu

Frontiers in Aging Neuroscience

Original Research

Accepted on 25 Feb 2026

Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the Dementia Platform Korea Trial-Ready Registry

in Alzheimer's Disease and Related Dementias

Young Hyeon Ahn
Jin Gu Kang
Dahyeon Choi
Dae-Jin Kim
Chan-Mo Yang
Sang-Yeol Lee
Young Hyun Jung
Sae Hwan Lee
Sung Hoon Yoon

Frontiers in Aging Neuroscience

Systematic Review

Published on 25 Feb 2026

Risk prediction models for cognitive impairment in patients with cerebral small vessel disease: a systematic review and meta-analysis

in Alzheimer's Disease and Related Dementias

Ting Li
Wen Shen
Yun Wang
Ping Jia
Xia Zeng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1679020

318 views

Systematic Review

Accepted on 24 Feb 2026

Efficacy of Dang Gui Shao Yao San in Treating Vascular Dementia in Animal Models: A Systematic Review and Meta-Analysis

in Alzheimer's Disease and Related Dementias

Gaoxuan Qu
Yifan Bi
Lingzhi Wang
Li Xu
Yan Zhang
Yan Ma
Caijun Tian
Zhe Zhang

Frontiers in Aging Neuroscience

Original Research

Accepted on 24 Feb 2026

PPARG as a Central Regulator of Ferroptosis in Alzheimer's Disease: Integrated Transcriptomic, Single-Cell, and Experimental Evidence

in Alzheimer's Disease and Related Dementias

Yuxuan Mo
Lingjia Tang
Ningning Wu
Hong Xu

Frontiers in Aging Neuroscience

Original Research

Accepted on 24 Feb 2026

Icaritin Ameliorates Mitochondrial Dysfunction and Autophagy Impairment in Cellular Models of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

LingQiong Xia
Tingting Liu
Zhengping Li
Xianfa Ao
Qiang Chen
Xinyu Zhou
Qianfeng Jiang
Nanqu Huang
Yong Luo

Frontiers in Aging Neuroscience

Review

Accepted on 23 Feb 2026

Molecular Mechanism of Alzheimer's disease using integrated multi-OMICs

in Alzheimer's Disease and Related Dementias

Mera Alhusaini
Bashair M Mussa
Rifat Hamoudi
Hamid Alhaj
Burcu Yener Ilce

Frontiers in Aging Neuroscience

Original Research

Published on 23 Feb 2026

Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment

in Alzheimer's Disease and Related Dementias

Zimeng Tang
Ruonan Huang
Xin Tan
Longjian Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1654758

243 views

Correction

Published on 23 Feb 2026

Correction: The efficacy versus evidence quality of multicomponent exercise for cognitive health in older adults: an umbrella review

in Alzheimer's Disease and Related Dementias

Weibao Liang
Chuannan Liu
Xujie Yan
Shuting Xu
Jianmin Dai
Wenbai Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1798753

202 views

2,251 articles

articles

Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor

A novel virtual reality-integrated multi-modal intervention for community-dwelling older adults with mild cognitive impairment: protocol for a randomized controlled trial

Deep learning for FDG-PET classification in patients with Alzheimer’s disease, dementia with Lewy bodies and their mixed pathology: a solution for diagnostic heterogeneity

Intervention of Ginseng-Derived Macromolecular Drugs in Alzheimer's Disease: Exploring Mechanisms and Assessing Potential

Retraction: Corrigendum: Identification of Cerebral Metal Ion Imbalance in the Brain of Ageing Octodon degus

Retraction: Identification of cerebral metal ion imbalance in the brain of ageing Octodon degus

TAS2R38 taster variants-linked MGAM expression in Alzheimer’s disease: a novel target for precision drug repurposing

Targeting the astrocytic metabolic cascade in Alzheimer’s disease: mechanisms, challenges and opportunities

Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communication

Exploring the neuroprotective mechanism of Tongqiao Huashuan granules in vascular dementia based on PLCγ1/IP3R signaling pathway

Glial Lactate Metabolism and Transport in Alzheimer's Disease

Associations of anticholinergic burden of medication with cognitive decline and longitudinal brain atrophy in the Alzheimer’s disease spectrum

Mitochondrial dysfunction in Alzheimer's Disease and Related Sex Differences

Dysregulated Glucose Metabolism in the Visual Cortex of Human Subjects with Mild Cognitive Impairment and Alzheimer's Disease

Rethinking cervical deep lymphovenous anastomosis in Alzheimer’s disease: problems and prospects

Molecular Mechanisms Underlying Exercise-Enhanced Autophagy in Improving Neuroplasticity in Alzheimer's disease

Liver–metabolic stress, apolipoprotein E ε4, and cognition and amyloid burden: findings from the Dementia Platform Korea Trial-Ready Registry

Risk prediction models for cognitive impairment in patients with cerebral small vessel disease: a systematic review and meta-analysis

Efficacy of Dang Gui Shao Yao San in Treating Vascular Dementia in Animal Models: A Systematic Review and Meta-Analysis

PPARG as a Central Regulator of Ferroptosis in Alzheimer's Disease: Integrated Transcriptomic, Single-Cell, and Experimental Evidence

Icaritin Ameliorates Mitochondrial Dysfunction and Autophagy Impairment in Cellular Models of Alzheimer's Disease

Molecular Mechanism of Alzheimer's disease using integrated multi-OMICs

Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment

Correction: The efficacy versus evidence quality of multicomponent exercise for cognitive health in older adults: an umbrella review