Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 15 May 2025

Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice

in Alzheimer's Disease and Related Dementias

Yejin Park
Subin Moon
Harry Jung
Songyi Park
Ju Won Kim
Dan-Gyeong Song
Yong-Ho In
Sang Won Han
Jong-Hee Sohn
Chan Hee Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579411

441 views

Systematic Review

Published on 15 May 2025

Diagnostic value of olfactory function testing for Alzheimer’s disease and mild cognitive impairment: a systematic review and meta-analysis

in Alzheimer's Disease and Related Dementias

Yuxuan Liu
Yunpeng Cao
Hongquan Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1551939

317 views

Review

Published on 14 May 2025

Iron responsive elements mRNA regulate Alzheimer’s amyloid precursor protein translation through iron sensing

in Alzheimer's Disease and Related Dementias

Mateen A. Khan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1483913

285 views

Correction

Published on 14 May 2025

Corrigendum: Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer's disease in rodent models by targeting the microbiota-gut-brain axis

in Alzheimer's Disease and Related Dementias

Diling Chen
Xin Yang
Jian Yang
Guoxiao Lai
Tianqiao Yong
Xiaocui Tang
Ou Shuai
Gailian Zhou
Yizhen Xie
Qingping Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1593725

198 views

Original Research

Published on 14 May 2025

Plasma neurofilament light chain mediates the effect of subsyndromal symptomatic depression on cognitive decline in older adults

in Alzheimer's Disease and Related Dementias

Chunhua Zhang
Bingyu Li
Kok Pin Ng
Guojuan Huang
Xijin Wang
Min Kong
Maowen Ba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547394

272 views

Original Research

Published on 14 May 2025

Unravelling the interplay: brain regional atrophy and neuropsychological function in early Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Doyun Heo
Min-Seong Kim
Yun-Jin Lee
Seon-Kyeong Kim
Yong Sung Kim
Wonjae Sung
Hee-Jin Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1508849

409 views

Original Research

Published on 14 May 2025

Identification and validation of pyroptosis-related genes in Alzheimer’s disease based on multi-transcriptome and machine learning

in Alzheimer's Disease and Related Dementias

Yuntai Wang
Yilin Li
Lu Zhou
Yihuan Yuan
Chuanfei Liu
Zimeng Zeng
Yuanqi Chen
Qi He
Zhuoze Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1568337

399 views

Original Research

Accepted on 13 May 2025

Blood Essential Trace Elements and Alzheimer's Disease Biomarkers in Midlife

in Alzheimer's Disease and Related Dementias

Xin Wang
Kelly M Bakulski
Carrie A Karvonen-Gutierrez
Sung Kyun Park
David Morgan
Brian P Jackson
Roger Albin
Henry Paulson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1539749

Original Research

Accepted on 13 May 2025

Association Between Sarcopenic Obesity and Dementia in the Chinese Elderly Using Different Definitions of Obesity: Evidence from the CHARLS

in Alzheimer's Disease and Related Dementias

Lang Peng
Qingwei Xiang
Ge Jia
Renyi Yin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540272

Review

Accepted on 12 May 2025

Infections with Chlamydia pneumoniae and SARS-CoV-2 and Alzheimer's disease pathogenesis

in Alzheimer's Disease and Related Dementias

Alexa Romanella
Maegan McCall
Rachel Corwin
Alaha Abdul Faruq
Emily Lingo
Sanya Bhambhani
Christine Hammond
Brian Joseph Balin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587782

206 views

Review

Published on 12 May 2025

Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Dandan Shi
Xiaochen Guo
Ziqi Ning
Yaoyao Zhang
Fang Liu
Meixia Liu
Yun Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1544241

263 views

Original Research

Accepted on 09 May 2025

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

in Alzheimer's Disease and Related Dementias

Li Wu
Renxin Zhang
Yichao Wang
Shaoxing Dai
Naixue Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571783

Original Research

Published on 09 May 2025

Blood biomarkers as surrogate endpoints in Alzheimer’s disease research

in Alzheimer's Disease and Related Dementias

Guogen Shan
Hui Li
Yahui Zhang
Guoqiao Wang
Charles Bernick

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576373

411 views

Review

Accepted on 07 May 2025

Advancements in Multi-Omics Research to Addressing Challenges in Alzheimer's Disease: A Systems Biology Approach Utilizing Molecular Biomarkers and Innovative Strategies

in Alzheimer's Disease and Related Dementias

Madison Cardillo
Keyura Katam
Prashanth Survajahala

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591796

Review

Published on 07 May 2025

Polyphenols and miRNA interplay: a novel approach to combat apoptosis and inflammation in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Minji Zhou
Xiu'e Pang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571563

848 views

Study Protocol

Published on 07 May 2025

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)

in Alzheimer's Disease and Related Dementias

Gessica Sala
Luca Cuffaro
Federico Emanuele Pozzi
Simona Andreoni
Chiara Bazzini
Elisa Conti
Chiara Paola Zoia
Simone Beretta
Lucio Tremolizzo
Giuseppe Bellelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581892

619 views