Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Mini Review

Published on 25 Apr 2025

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

in Alzheimer's Disease and Related Dementias

Ya-nan Ma
Xiqi Hu
Kenji Karako
Peipei Song
Wei Tang
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576020

772 views

Original Research

Accepted on 24 Apr 2025

Mirodenafil Improves Cognitive Function by Reducing Microglial Activation and Blood-Brain Barrier Permeability in ApoE4 KI Mice

in Alzheimer's Disease and Related Dementias

Yejin Park
Subin Moon
Harry Jung
Songyi Park
Ju Won Kim
Dan-Gyeong Song
Yong-Ho In
Sang Won Han
Jong-Hee Sohn
Chan Hee Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579411

Review

Accepted on 23 Apr 2025

Iron Responsive Elements (IREs)-mRNA Regulate Alzheimer's Amyloid Precursor Protein (APP) Translation through Iron Sensing

in Alzheimer's Disease and Related Dementias

Mateen A. Khan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1483913

Original Research

Accepted on 23 Apr 2025

Blood biomarker as surrogate endpoint in Alzheimer's disease research

in Alzheimer's Disease and Related Dementias

Guogen Shan
Hui Li
Yahui Zhang
Guoqiao Wang
Charles Bernick

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576373

136 views

Systematic Review

Published on 23 Apr 2025

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

in Alzheimer's Disease and Related Dementias

Giulia Marafioti
Laura Culicetto
Desirèe Latella
Angela Marra
Angelo Quartarone
Viviana Lo Buono

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549134

823 views

Review

Published on 23 Apr 2025

The role of quantitative EEG biomarkers in Alzheimer’s disease and mild cognitive impairment: applications and insights

in Alzheimer's Disease and Related Dementias

Yue Yuan
Yang Zhao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522552

874 views

Original Research

Published on 22 Apr 2025

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

in Alzheimer's Disease and Related Dementias

Lingjing Zhang
Yanwei Wang
Yuming Liu
Zi Ye
Zhaohui Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1492804

938 views

Original Research

Published on 22 Apr 2025

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

in Alzheimer's Disease and Related Dementias

Li Zhao
Lingyun Liu
Miao Lin
Linyun Xie
Hui Hong
Qingze Zeng
Shuyue Wang
Ruiting Zhang
Zhenhua Zhao
Peiyu Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549072

804 views

Original Research

Accepted on 21 Apr 2025

Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer's disease biomarkers and brain structure

in Alzheimer's Disease and Related Dementias

Zihao Zhang
Lingzhi Ma
Liangyu Huang
Yangke Zhu
Haihua Guo
Lanyang Wang
Wei Zhang
Lan Tan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1457160

Study Protocol

Accepted on 18 Apr 2025

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the World-Wide FINGERS network)

in Alzheimer's Disease and Related Dementias

Gessica Sala
Luca Cuffaro
Federico Emanuele Pozzi
Simona Andreoni
Chiara Bazzini
Elisa Conti
Chiara Paola Zoia
Simone Beretta
Lucio Tremolizzo
Giuseppe Bellelli

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1581892

113 views

Review

Accepted on 17 Apr 2025

Polyphenols and miRNA interplay: A novel approach to combat apoptosis and inflammation in Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Minji zhou
Xiue Pang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571563

162 views

Original Research

Accepted on 16 Apr 2025

Unravelling the Interplay: Brain Regional Atrophy and Neuropsychological Function in Early Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Doyun HEO
Minseong KIM
Yunjin LEE
Seonkyeong KIM
Wonjae SEONG
Yongseong KIM
Heejin Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1508849

125 views

Original Research

Published on 16 Apr 2025

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

in Alzheimer's Disease and Related Dementias

Huan Chen
Fangzhen Guo
Yan Zhao
Wei Liu
Bingyu Chen
Chang Wang
Lining Huang
Sufang Jiang
Xiaowei Ma
Huiling Ren

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1572976

880 views

Original Research

Published on 15 Apr 2025

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors

in Alzheimer's Disease and Related Dementias

Alexandre Guimarães de Almeida Barros
Thayana Oliveira Soares
Ariane Flávia Almeida Lage
Marco Túlio Gualberto Cintra
Jonas Jardim de Paula
Olívio Brito Malheiro
Antonio Eiras Falcão
Christiano Altamiro Coli Nogueira
Leandro Braz de Carvalho
Marco Aurélio Romano Silva

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1557016

765 views

Review

Accepted on 14 Apr 2025

Applications of Event-Related Potentials in Alzheimer's Disease ：Present Status and Prospects (a systematic review and analysis) Author names and affiliations

in Alzheimer's Disease and Related Dementias

Qian Liang
Zhilin Chen
Xiaohui Tang
Xijin Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1513049

Original Research

Published on 14 Apr 2025

Cerebrospinal fluid levels of tumour necrosis factor-α and its receptors are not associated with disease progression in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Manal Aljuhani

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547185

319 views

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

Mirodenafil Improves Cognitive Function by Reducing Microglial Activation and Blood-Brain Barrier Permeability in ApoE4 KI Mice

Iron Responsive Elements (IREs)-mRNA Regulate Alzheimer's Amyloid Precursor Protein (APP) Translation through Iron Sensing

Blood biomarker as surrogate endpoint in Alzheimer's disease research

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

The role of quantitative EEG biomarkers in Alzheimer’s disease and mild cognitive impairment: applications and insights

Early identification of mild cognitive impairment: an innovative model using ocular biomarkers

Relationship between cerebrospinal fluid circulation markers, brain degeneration, and cognitive impairment in cerebral amyloid angiopathy

Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer's disease biomarkers and brain structure

Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the World-Wide FINGERS network)

Polyphenols and miRNA interplay: A novel approach to combat apoptosis and inflammation in Alzheimer's disease

Unravelling the Interplay: Brain Regional Atrophy and Neuropsychological Function in Early Alzheimer's Disease

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice

Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors

Applications of Event-Related Potentials in Alzheimer's Disease ：Present Status and Prospects (a systematic review and analysis) Author names and affiliations

Cerebrospinal fluid levels of tumour necrosis factor-α and its receptors are not associated with disease progression in Alzheimer’s disease

Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice