Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 24 Nov 2025

Preclinical Alzheimer's and vascular biomarkers alter brain aging in cognitively normal adults: a MRI-based study

in Alzheimer's Disease and Related Dementias

Unai Torres
David Bernal
Ibai Gurrutxaga
Ainara Estanga
Pablo Martínez-Lage
Olatz Arbelaitz

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1653074

132 views

Original Research

Published on 24 Nov 2025

Music-induced physiological markers for detecting Alzheimer's disease using machine learning

in Alzheimer's Disease and Related Dementias

Rodrigo Lima
Gonçalo Barradas
Sergi Bermúdez i Badia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701970

248 views

Original Research

Accepted on 21 Nov 2025

Machine Learning-Based Early Screening of Mild Cognitive Impairment Using Nutrition-Related Biomarkers and Functional Indicators

in Alzheimer's Disease and Related Dementias

Ling Yuan
Yao Zhang
Yiwen Wu
Anke Zhang
He Bai
Mengyao He
Zhaoxin Wang
Liqiang Zheng

Frontiers in Aging Neuroscience

Original Research

Accepted on 21 Nov 2025

Follicle-Stimulating Hormone Linked to Cognitive Decline and Amyloid Burden in Postmenopausal Women

in Alzheimer's Disease and Related Dementias

Sheng-Min Wang
Chaiho Jeong
Yoo Hyun Um
Dong Woo Kang
Sunghwan Kim
Soyoung Lee
Chang Uk Lee
Howard J Aizenstein
Ki-hyun Baek
Hyun Kook Lim

Frontiers in Aging Neuroscience

Review

Accepted on 21 Nov 2025

Mechanisms to Medicines: Navigating Drug Repurposing Strategies in Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Sara A Khan
Khushi Raza
Prachi Tiwari
Mohamed Eltenani
Syed Arman Rabbani
Suhel Parvez

Frontiers in Aging Neuroscience

105 views

Original Research

Accepted on 19 Nov 2025

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

in Alzheimer's Disease and Related Dementias

Melissa L Garcia
Adam R Denton
Nateka L Jackson
Michael David Scofield
Lori L McMahon

Frontiers in Aging Neuroscience

181 views

Original Research

Published on 19 Nov 2025

MRI-derived global small vessel disease burden serves as a marker of hippocampal sclerosis and clinical stage across the probable Alzheimer’s disease continuum

in Alzheimer's Disease and Related Dementias

Ya-Che Chen
Ting-Bin Chen
Hsin-Chieh Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692747

774 views

Original Research

Published on 19 Nov 2025

Dysfunctional default mode and visual networks underlie cognitive deficits in dementia with Lewy bodies: a resting-state fMRI study

in Alzheimer's Disease and Related Dementias

Zhou Su
Mengran Liu
Jun Kuai
Tingting Yi
Yuechang Zheng
Xinran Bao
Jiyu Ji

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1630826

296 views

Original Research

Accepted on 18 Nov 2025

Validation of the Robustness of Blood-based Biomarkers for Predicting Amyloid-β Positivity in Chinese Populations

in Alzheimer's Disease and Related Dementias

Ying Wang
Liang Cui
Fengfeng Pan
Zhen Zhang
Lin Huang
Ya Miao
Yihui Guan
Qihao Guo

Frontiers in Aging Neuroscience

229 views

Perspective

Accepted on 18 Nov 2025

Rethinking the Diagnosis of Primary Progressive Aphasia: Current Challenges and Future Directions

in Alzheimer's Disease and Related Dementias

Joel Macoir
Monica Lavoie
Guillaume Duboisdindien
Robert Jr Laforce

Frontiers in Aging Neuroscience

Systematic Review

Accepted on 18 Nov 2025

The EEG Analysis and Identification of Alzheimer's Disease: A Review

in Alzheimer's Disease and Related Dementias

Jinying Bi
Fei Wang
Fangzhou Hu
Shuai Han
Yuting Wang
Zhijian Fu
Xin Zhang

Frontiers in Aging Neuroscience

Original Research

Accepted on 17 Nov 2025

Exploring the Mahuang Fuzi Xixin Decoction's Mechanism for Treating Alzheimer's Disease (AD) Using Molecular Docking and Network Pharmacology

in Alzheimer's Disease and Related Dementias

Che Chen
Qianfeng Shao
Sheng Zhou

Frontiers in Aging Neuroscience

Opinion

Accepted on 17 Nov 2025

The mechanosensitive Piezo1 channel mechanism of Alzheimer's disease and implications to development of therapeutic or early detection strategy

in Alzheimer's Disease and Related Dementias

Lin-Hua Jiang
Mo Zhang
Huifang Hou
Hui Li
Xinyang Bai
Huina Song
Lu Wang

Frontiers in Aging Neuroscience

113 views

Original Research

Accepted on 17 Nov 2025

Anatomically Refined Entorhinal Cortex Segmentation Improves MRI-Based Early Diagnosis of Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Yongha Gi
Sangyoon Park
Hyungjin Lim
Jeongwon Lee
A Hyun Jung
Seol-Hee Baek
Jong Hyun Kim
Byung-Jo Kim
Myonggeun Yoon

Frontiers in Aging Neuroscience

Original Research

Accepted on 17 Nov 2025

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

in Alzheimer's Disease and Related Dementias

Kiyoshi Kikuchi
Seiya Takada
Shotaro Otsuka
Kazuki Nakanishi
Harutoshi Sakakima
Hyuma Makizako
Nobuhiro Tahara
Hisaaki Uchikado
Naoto Shiomi
Satomi Ooba

Frontiers in Aging Neuroscience

Mini Review

Accepted on 17 Nov 2025

LRP1 at the Crossroads of Aβ Clearance and Therapeutic Targeting in Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Yuepeng Deng
Haolin Yin
Zihao Lu
Huan Lan
Wenxiong Liu
Chao Zuo
Nanfang Pan
Xiaohe Tian
Qiyong Gong

Frontiers in Aging Neuroscience