Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Published on 04 Jun 2025

Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS

in Alzheimer's Disease and Related Dementias

Lang Peng
Qingwei Xiang
Ge Jia
Renyi Yin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1540272

248 views

Original Research

Accepted on 03 Jun 2025

A new pathway for neuroprotection against Tau hyperphosphorylation via δ-Opioid receptor initiated inhibition of CDK5 and AMPK signaling

in Alzheimer's Disease and Related Dementias

Jiahui Li
Yuan Xu
Gianfranco Balboni
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587219

Original Research

Accepted on 03 Jun 2025

Voxel-based and surface-based morphometry in the cortical thickness, and cortical and subcortical grey matter volume in patients with mild to moderate Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Kaidi Li
Dingling Xie
Zhengyong Zhang
Chunyu Fu
Chunyang Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1546977

121 views

Review

Published on 02 Jun 2025

Neurobiological and therapeutic landmarks of depression associated with Alzheimer’s disease dementia

in Alzheimer's Disease and Related Dementias

Ilinca Untu
Michael Davidson
Gabriela-Dumitrita Stanciu
Jonathan Rabinowitz
Romeo-Petru Dobrin
Diana-Sabina Vieru
Bogdan-Ionel Tamba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1584607

488 views

Review

Accepted on 30 May 2025

Dysregulated calcium signaling in the aged primate association cortices: Vulnerability to Alzheimer's disease neuropathology

in Alzheimer's Disease and Related Dementias

Amy F T Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinar Bolat
Dibyadeep Datta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610350

141 views

Original Research

Accepted on 30 May 2025

Impact of Cognitive Decline on the Physical Functioning of Older Adults in Southern Brazil: A Cross-Sectional Study

in Alzheimer's Disease and Related Dementias

Andréa Kruger Gonçalves
Valeria Feijo Martins
Ana Carolina Kanitz
Flávia Gomes Martinez
Leonardo Alexandre Peyré-Tartaruga
Raphael Machado Castilhos
Aline Nogueira Haas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549764

142 views

Original Research

Published on 30 May 2025

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

in Alzheimer's Disease and Related Dementias

Li Wu
Renxin Zhang
Yichao Wang
Shaoxing Dai
Naixue Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571783

488 views

Original Research

Published on 30 May 2025

Blood essential trace elements and Alzheimer’s disease biomarkers in midlife

in Alzheimer's Disease and Related Dementias

Xin Wang
Kelly M. Bakulski
Carrie A. Karvonen-Gutierrez
Sung Kyun Park
David Morgan
Brian P. Jackson
Roger L. Albin
Henry L. Paulson

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1539749

406 views

Original Research

Accepted on 29 May 2025

a-klotho as a biomarker of amyloid b levels in the cerebrospinal fluid

in Alzheimer's Disease and Related Dementias

Jacob Raber
Alexandra Pederson
Emily Bunnell
Nora Mattek
Nora Gray
Steven G. Kohama
Alison R Weiss
Joseph Quinn
Henryk F Urbanski

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599402

184 views

Original Research

Accepted on 28 May 2025

The effect of periodontal status in the associations between socioeconomic status and cognitive performance: a mediation analysis in older adults

in Alzheimer's Disease and Related Dementias

Heming Zhang
Hongxia Xiang
Lin Zhang
Zhiyang Chen
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1524268

132 views

Original Research

Accepted on 27 May 2025

Effects of West Nile Virus on behavioral and cognitive performance, cortical Ab pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice

in Alzheimer's Disease and Related Dementias

Jacob Raber
Abigail O'Niel
Christopher J Parkins
Alexandra Pederson
Elizabeth Saltonstall
Emily Bunnell
Ria Aggarwal
Phoebe Sandholm
Kat Kessler
Henry F Harrison

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1600119

187 views

Original Research

Published on 27 May 2025

Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Marianna Riello
Monica Moroni
Stefano Bovo
Flavio Ragni
Manuela Buganza
Raffaella Di Giacopo
Marco Chierici
Lorenzo Gios
Matteo Pardini
Federico Massa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1565006

607 views

Original Research

Accepted on 26 May 2025

CITA GO-ON Study. A community based Multidomain Lifestyle Intervention to prevent cognitive decline. Protocol design and study progressrecruitment process

in Alzheimer's Disease and Related Dementias

Mikel Tainta
Mirian Ecay-Torres
Myriam Barandiaran
Ainara Estanga
Carolina Lopez
Miren Altuna
Ane Iriondo
Jon Saldias
Maite Garcia-Sebastian
Marta Cañada

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1539711

171 views

Original Research

Accepted on 23 May 2025

Brain microvascular calcification is increased in human donors with dementia compared to elderly controls: A pilot study

in Alzheimer's Disease and Related Dementias

Kelly Borges
Isabelle Lombardi
Mackenzie Sivilli
Joseph Aabye
Isabella Romano
Saud Nasruddin
Mugdha Vijay Padalkar
Daniel Moussouros
Olga V. Savinova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1557625

182 views

Original Research

Accepted on 22 May 2025

A High-Accuracy, Low-Cost Blood Test for Alzheimer's Disease: Validating P-tau181/Aβ42 in Real-World Cohorts

in Alzheimer's Disease and Related Dementias

Dequan Liu
Hang Li
Qing Liu
Haiyan Li
Yuanyuan Tang
Kaiting Cheng
Tong Li
Yulan Chu
Xiaodong Jia
Wenying Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599761

131 views

Original Research

Published on 15 May 2025

Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice

in Alzheimer's Disease and Related Dementias

Yejin Park
Subin Moon
Harry Jung
Songyi Park
Ju Won Kim
Dan-Gyeong Song
Yong-Ho In
Sang Won Han
Jong-Hee Sohn
Chan Hee Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579411

1,440 views