Frontiers in Aging Neuroscience | Neuroinflammation and Neuropathy

Original Research

Published on 11 Feb 2026

Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases

in Neuroinflammation and Neuropathy

Jayashankar Jayaprakash
Solomon Tebeje Gizaw
Divyavani Gowda
Hiroshi Hinou
Shin-Ichiro Nishimura
Shu-Ping Hui
Siddabasave Gowda B. Gowda

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1757306

293 views

Review

Accepted on 10 Feb 2026

Interconnected Roles of Astrocytes and the Blood–Brain Barrier in Parkinson's Disease: Pathological Evidence, Mechanistic Insights, and Knowledge Gaps

in Neuroinflammation and Neuropathy

Anna C Stoll
Ashley S. Harms

Frontiers in Aging Neuroscience

Original Research

Published on 10 Feb 2026

Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats

in Neuroinflammation and Neuropathy

Hany A. Elkattawy
Mohamed El-Sherbiny
Nehal Elsherbiny
Reham M. Wahid
Sherein F. El-Sayed
Hanan A. Henidi
Randa El-Gamal
Sultan Alshehri
Syed Mohammed Basheeruddin Asdaq

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1742343

513 views

Original Research

Published on 06 Feb 2026

Physical exercise/melatonin interaction in young rats fed a low-protein diet: a behavioral, electrophysiological, and redox balance analysis

in Neuroinflammation and Neuropathy

Maria Luísa Figueira de Oliveira
Jennyfer Martins de Carvalho
José Anderson da Silva Gomes
Valéria Bianca de Souza Santos
Leucio Duarte Vieira Filho
Arthur Gabriel Alves Furtado de Carvalho Noya
Rubem Carlos Araujo Guedes

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1740062

416 views

Original Research

Published on 05 Feb 2026

IL1A enhances TNF-induced retinal ganglion cell death

in Neuroinflammation and Neuropathy

Katherine M. Andersh
Michael MacLean
Gareth R. Howell
Richard T. Libby

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1754881

436 views

Systematic Review

Published on 04 Feb 2026

Research trends on neuroinflammation in Parkinson’s disease: an exploratory analysis

in Neuroinflammation and Neuropathy

Yan-Jun Chen
Ming-Rong Xie
Fang Liu
Sheng-Qiang Zhou
Bo Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1699038

588 views

Original Research

Published on 03 Feb 2026

Spinal glial cell derived extra-pituitary prolactin contributes to postoperative pain in females

in Neuroinflammation and Neuropathy

Mayur J. Patil
Sergei Belugin
Michael Henry
Anahit H. Hovhannisyan
Priscilla A. Barba-Escobedo
Jennifer M. Mecklenburg
Vincent Goffin
Gregory Dussor
Theodore J. Price
Armen N. Akopian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1741102

457 views

Systematic Review

Accepted on 02 Feb 2026

The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer's and Parkinson's disease: a systematic review and meta-analysis

in Neuroinflammation and Neuropathy

Ana Flavia Fernandes Ferreira
Ana Caroline Santos-Silva
Beatriz Gangale Muratori
Luiz R G Britto

Frontiers in Aging Neuroscience

146 views

Original Research

Accepted on 30 Jan 2026

Cooling the Burn: EMLA Alone vs Paravertebral Block Plus EMLA for Improving Tolerability of 8% Capsaicin Patch Application in Thoracic Postherpetic Neuralgia – A Retrospective Cohort Study

in Neuroinflammation and Neuropathy

Hassan A Moria

Frontiers in Aging Neuroscience

139 views

Original Research

Published on 30 Jan 2026

From knowledge landscapes to network mechanisms: charting regulated cell death pathways in ALS

in Neuroinflammation and Neuropathy

Jingxuan Zhang
Zilin Zhao
Tianyue Xiang
Da Teng
Hejia Wan
Qiong Zhang
Xiaohui Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1742805

815 views

Review

Published on 27 Jan 2026

Dual roles of lactate and lactylation modification in the nervous system: neuroprotection and neuroinjury

in Neuroinflammation and Neuropathy

TianLu Ran
YunLong Shen
DeJian Peng
Li Tang
ZiHeng Pan
XinYi Zeng
Hui Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1713583

395 views

Original Research

Published on 22 Jan 2026

Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis

in Neuroinflammation and Neuropathy

Shuoxi Liao
Hui Yang
Li Song
Lingli Shi
Zhike Lan
Wenrong Zhao
Zeyan Bao
Qiongli Hu
Xiaomei Tang
Sidian Zhuang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1713733

500 views

Original Research

Published on 21 Jan 2026

Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study

in Neuroinflammation and Neuropathy

Xinhao Chen
Chengxia Wei
Danli Zhao
Chenmei Zhou
Wenjing Wang
Gendi Lu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1733972

476 views

Review

Published on 20 Jan 2026

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

in Neuroinflammation and Neuropathy

Laurence Leclerc
Johanne Poudrier
Christopher Power
Grace Y. Lam
Emilia Liana Falcone

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1744415

5,438 views

Original Research

Published on 14 Jan 2026

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

in Neuroinflammation and Neuropathy

Juhong Zhang
Haizhu Ma
Jing Ke
Ziyi Tang
Zhiji Chen
Guijun Yang
Li Yang
Jialin Guo
Xiaoqi Yan
Changxiu Peng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1694514

838 views

Original Research

Published on 13 Jan 2026

Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024

in Neuroinflammation and Neuropathy

Zhilin Huang
Wanting Liu
Yating Zhang
BiXiang Zha
Ping Wang
Jun Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708008

1,196 views

Original Research

Published on 12 Jan 2026

Subclinical infection combined with surgery induced cognitive dysfunction: a novel adult mouse model for perioperative neurocognitive disorder

in Neuroinflammation and Neuropathy

Chenchen Xia
Xiao Zhang
Wanbing Dai
Yizhe Zhang
Ye Liu
Xiangyang Cheng
Yeke Zhu
Lili Huang
Minghao Tang
Yongxing Yao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1691681

820 views

Hypothesis and Theory

Published on 09 Jan 2026

The interplay of homeostasis, inflammation, and oxidative stress in neurodegenerative disorders: the role of biological markers, antioxidants, lithium, and TMS — a proposed framework for preventing neurodegenerative disorders through biomarkers and multimodal therapies

in Neuroinflammation and Neuropathy

Leonard Lado
Aruna Misir

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607669

1,972 views

Original Research

Published on 09 Jan 2026

Mechanistic insights into the anti-neuroinflammatory effects of cassia obtusifolia in Parkinson’s disease: a network pharmacology-based study

in Neuroinflammation and Neuropathy

Xinfu Lian
Yongjun Bai
Rong Xie
Wang Du
Lingbo Ma
Yuqian Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730009

857 views

Original Research

Published on 09 Jan 2026

A comprehensive evaluation of the associations between 12 composite inflammatory indices and all-cause mortality after stroke: a multicohort study

in Neuroinflammation and Neuropathy

Longyi Zheng
Rundong He
Shuang Tang
Jia Duan
Wenli Xing
Ao Qian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1754095

1,040 views

Original Research

Published on 09 Jan 2026

The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts

in Neuroinflammation and Neuropathy

Haining Zhang
Jiange Chen
Yuntian Ye
Hongyi Wang
Shun Fan
Wei Zhang
An Bao
Huanan Li
Jingui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1733007

970 views

Original Research

Published on 08 Jan 2026

Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients

in Neuroinflammation and Neuropathy

Wenfei Liang
Jingling Zhu
Xiuling Yang
Xiaohua He
Guoshun Li
Zhaobang Chen
Jiasheng Zhao
Kangqiang Yang
Bin Liao
Huiquan Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1654146

934 views

Review

Published on 17 Dec 2025

Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

in Neuroinflammation and Neuropathy

Yuliu Li
Yiqing Tan
Wei Zuo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1702993

871 views

Original Research

Published on 11 Dec 2025

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

in Neuroinflammation and Neuropathy

Songmei Ma
Lin Lin
Shuwen Zheng
Zhenjing Liu
Li Kong
Haiyun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599858

1,476 views

652 articles

articles

Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases

Interconnected Roles of Astrocytes and the Blood–Brain Barrier in Parkinson's Disease: Pathological Evidence, Mechanistic Insights, and Knowledge Gaps

Oxytocin restores cognitive function and attenuates neuroinflammation in chronic sleep-deprived aged rats

Physical exercise/melatonin interaction in young rats fed a low-protein diet: a behavioral, electrophysiological, and redox balance analysis

IL1A enhances TNF-induced retinal ganglion cell death

Research trends on neuroinflammation in Parkinson’s disease: an exploratory analysis

Spinal glial cell derived extra-pituitary prolactin contributes to postoperative pain in females

The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer's and Parkinson's disease: a systematic review and meta-analysis

Cooling the Burn: EMLA Alone vs Paravertebral Block Plus EMLA for Improving Tolerability of 8% Capsaicin Patch Application in Thoracic Postherpetic Neuralgia – A Retrospective Cohort Study

From knowledge landscapes to network mechanisms: charting regulated cell death pathways in ALS

Dual roles of lactate and lactylation modification in the nervous system: neuroprotection and neuroinjury

Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis

Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

The differential expression profiles of miRNA in serum-derived exosomes and its potential role in age-related hearing loss

Research trends and frontiers of astrocytes in cognitive impairment: a bibliometric analysis from 2015 to 2024

Subclinical infection combined with surgery induced cognitive dysfunction: a novel adult mouse model for perioperative neurocognitive disorder

The interplay of homeostasis, inflammation, and oxidative stress in neurodegenerative disorders: the role of biological markers, antioxidants, lithium, and TMS — a proposed framework for preventing neurodegenerative disorders through biomarkers and multimodal therapies

Mechanistic insights into the anti-neuroinflammatory effects of cassia obtusifolia in Parkinson’s disease: a network pharmacology-based study

A comprehensive evaluation of the associations between 12 composite inflammatory indices and all-cause mortality after stroke: a multicohort study

The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts

Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients

Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database