Frontiers in Aging Neuroscience

Original Research

Published on 12 Jan 2026

Neural control of anticipatory braking and lateral balance predicts fall risk in older adults: BMI-dependent mechanisms

Youjung Choi
Jiyoung Jeong
Hyungji Lee
Hyang Jun Lee
Ji Won Han
Ki Woong Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1699584

681 views

Original Research

Published on 12 Jan 2026

Identification and validation of an interpretable EEG-based machine learning model for the diagnosis of post-stroke cognitive impairment

Xinyang Wang
Jian Song
Weicheng Kong
Wei Wei
Haoran Shi
Peitao Xu
Yuqing Zhao
Jiayu Cai
Xiehua Xue

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1700771

844 views

Correction

Published on 12 Jan 2026

Correction: Differential effects of physical activity on behavioral and prefrontal responses during repetitive inhibitory control in older adults

Jae-Hoon Lee
Minchul Lee
Min-Seong Ha

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1768142

470 views

Original Research

Published on 09 Jan 2026

Mechanistic insights into the anti-neuroinflammatory effects of cassia obtusifolia in Parkinson’s disease: a network pharmacology-based study

Xinfu Lian
Yongjun Bai
Rong Xie
Wang Du
Lingbo Ma
Yuqian Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730009

901 views

Mini Review

Published on 09 Jan 2026

LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer’s disease

Yuepeng Deng
Haolin Yin
Zihao Lu
Huan Lan
Wenxiong Liu
Chao Zuo
Nanfang Pan
Xiaohe Tian
Qiyong Gong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1669405

1,655 views

Hypothesis and Theory

Published on 09 Jan 2026

The interplay of homeostasis, inflammation, and oxidative stress in neurodegenerative disorders: the role of biological markers, antioxidants, lithium, and TMS — a proposed framework for preventing neurodegenerative disorders through biomarkers and multimodal therapies

Leonard Lado
Aruna Misir

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607669

2,054 views

Original Research

Published on 09 Jan 2026

Cortical activation and functional connectivity between healthy elderly and Parkinson’s disease patients and between cognitive subgroups of Parkinson’s patients: a multichannel functional near-infrared spectroscopy study

Xiaodie Liu
Shanshan Zhou
Wenyi Chen
Mengyuan Chen
Yawen Pan
Huabao Xie
Yinghao Zhi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723770

698 views

Original Research

Published on 09 Jan 2026

A comprehensive evaluation of the associations between 12 composite inflammatory indices and all-cause mortality after stroke: a multicohort study

Longyi Zheng
Rundong He
Shuang Tang
Jia Duan
Wenli Xing
Ao Qian

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1754095

1,093 views

Original Research

Published on 09 Jan 2026

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

Ming Sun
Chao Wu
Jingjing Wu
Lixin Liu
Liang Gu
Zihao Wang
Xue Yang
Feng Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657523

1,122 views

Original Research

Published on 09 Jan 2026

Altered brain network dynamics and functional connectivity in subjective cognitive decline: an edge-centric network study

Xiaofan Wei
Baiwan Zhou
Juanling Li
Ruohong Xu
Wei Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1596537

1,016 views

Original Research

Published on 09 Jan 2026

Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease

Zhen Hu
Jing-jin Wan
Qin-qin Yan
Yu Fan
Jun Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1735522

1,284 views

Original Research

Published on 09 Jan 2026

The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts

Haining Zhang
Jiange Chen
Yuntian Ye
Hongyi Wang
Shun Fan
Wei Zhang
An Bao
Huanan Li
Jingui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1733007

1,007 views

Correction

Published on 08 Jan 2026

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Yu Wang
Li Wang
Yunhong Du
Xiaoye Ma
Lili Sun
Xiujie Zhang
Wenli Rong
Jianwei Li
Yao Shi
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1763134

744 views

Original Research

Published on 08 Jan 2026

Separating cognitive and motor contributions to iADL difficulties in Parkinson’s disease

Rekha Ravikumar
Marta Statucka
Melanie Cohn

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1732479

869 views

Original Research

Published on 08 Jan 2026

Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients

Wenfei Liang
Jingling Zhu
Xiuling Yang
Xiaohua He
Guoshun Li
Zhaobang Chen
Jiasheng Zhao
Kangqiang Yang
Bin Liao
Huiquan Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1654146

963 views

Original Research

Published on 08 Jan 2026

Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes

Joel Eyamu
Boncho Ku
Kahye Kim
Kun Ho Lee
Jaeuk U. Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675330

1,265 views

Original Research

Published on 07 Jan 2026

The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer’s disease: a resting-state fMRI study

Benqin Liu
Chunbing Chen
Pan Cai
Jiaren Zhang
Li Yang
Xu Chen
Xuejin Ma
Xuetao Jiang
Anjie Zhang
Linfeng Song

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1716076

1,271 views

Original Research

Published on 06 Jan 2026

Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women

Sheng-Min Wang
Chaiho Jeong
Yoo Hyun Um
Dong Woo Kang
Sunghwan Kim
Soyoung Lee
Chang Uk Lee
Howard J. Aizenstein
Ki-Hyun Baek
Hyun Kook Lim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1697255

1,295 views

Original Research

Published on 05 Jan 2026

Machine learning models for the prediction of levodopa response to tremor in Parkinson’s disease

Fangfei Li
Shinuan Lin
Rui Yan
Yusha Cui
Kang Ren
Zhonglue Chen
Lingyan Ma
Tao Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1690155

1,097 views

Perspective

Published on 05 Jan 2026

AI agents in Alzheimer’s disease management: challenges and future directions

Gerasimos Grammenos
Aristidis G. Vrahatis
Konstantinos Lazaros
Themis P. Exarchos
Panagiotis Vlamos
Marios G. Krokidis

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1735892

1,828 views

Original Research

Published on 05 Jan 2026

Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment

Jiyue Qin
Carol A. Derby
Grace Liu
Cuiling Wang
Richard P. Sloan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1707771

1,274 views

Original Research

Published on 05 Jan 2026

Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants

Yucheng Gu
Xiaoyuan Li
Nihong Chen
Feng Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708268

1,260 views

Original Research

Published on 05 Jan 2026

Factors associated with sleep disorders in elderly patients with Parkinson’s disease and cognitive impairment and the nomogram model development

Yimei Zhang
Liyan Sun
Haitao Chi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670915

1,010 views

Original Research

Published on 02 Jan 2026

Quantity and quality of care and staff knowledge regarding people with Parkinson’s disease in long-term nursing care: “real-life” results from the German Care4PD study

Odette Fründt
Verena Caroline Lamb
Anne-Marie Hanff
Tobias Mai
Christiane Kirchner
Ali Amouzandeh
Carsten Buhmann
Rejko Krüger
Alfons Schnitzler
Martin Südmeyer

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1701254

1,004 views

7,808 Publications

volumes

Volume 17 - 2025

Neural control of anticipatory braking and lateral balance predicts fall risk in older adults: BMI-dependent mechanisms

Identification and validation of an interpretable EEG-based machine learning model for the diagnosis of post-stroke cognitive impairment

Correction: Differential effects of physical activity on behavioral and prefrontal responses during repetitive inhibitory control in older adults

Mechanistic insights into the anti-neuroinflammatory effects of cassia obtusifolia in Parkinson’s disease: a network pharmacology-based study

LRP1 at the crossroads of Aβ clearance and therapeutic targeting in Alzheimer’s disease

The interplay of homeostasis, inflammation, and oxidative stress in neurodegenerative disorders: the role of biological markers, antioxidants, lithium, and TMS — a proposed framework for preventing neurodegenerative disorders through biomarkers and multimodal therapies

Cortical activation and functional connectivity between healthy elderly and Parkinson’s disease patients and between cognitive subgroups of Parkinson’s patients: a multichannel functional near-infrared spectroscopy study

A comprehensive evaluation of the associations between 12 composite inflammatory indices and all-cause mortality after stroke: a multicohort study

Single-cell analysis of microglial activation after traumatic brain injury reveals immune signaling pathways linked to mitochondrial dysfunction and brain aging

Altered brain network dynamics and functional connectivity in subjective cognitive decline: an edge-centric network study

Exploring rare coding variants in UK biobank: preliminary associations with motor neuron disease

The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts

Correction: Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Separating cognitive and motor contributions to iADL difficulties in Parkinson’s disease

Development and validation of a prognostic nomogram for predicting ventilator-associated pneumonia risk in elderly large vessel occlusion ischemic stroke after endovascular therapy patients

Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes

The alterations in brain network functional gradients and dynamic functional connectivity in Alzheimer’s disease: a resting-state fMRI study

Follicle-stimulating hormone linked to cognitive decline and amyloid burden in postmenopausal women

Machine learning models for the prediction of levodopa response to tremor in Parkinson’s disease

AI agents in Alzheimer’s disease management: challenges and future directions

Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment

Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants

Factors associated with sleep disorders in elderly patients with Parkinson’s disease and cognitive impairment and the nomogram model development

Quantity and quality of care and staff knowledge regarding people with Parkinson’s disease in long-term nursing care: “real-life” results from the German Care4PD study