Frontiers in Aging

Original Research

Published on 25 Jun 2025

The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy

in Interventions in Aging

Jiexian Chen
Joshua Berg
Calvin M. Burns
Hanyi Jia
Xinna Li
Richard A. Miller
S. Joseph Endicott
Gonzalo Garcia

Frontiers in Aging

doi 10.3389/fragi.2025.1621808

927 views

Original Research

Published on 25 Jun 2025

Age and sex-specific changes in mitochondrial quality control in skeletal and cardiac muscle

in Aging, Metabolism and Redox Biology

Catherine B. Springer-Sapp
Olayinka Ogbara
Maria Canellas Da Silva
AbryAnna Henderson
Yuan Liu
Steven J. Prior
Sarah Kuzmiak-Glancy

Frontiers in Aging

doi 10.3389/fragi.2025.1606110

815 views

Original Research

Accepted on 24 Jun 2025

Chronic Pain in the Chilean population: Risk factors prevalence and cognitive associations

in Healthy Longevity

Hernán Hernández
Carolina Ochoa-Rosales
Agustin Ibanez
Lorena Oyanedel
Loreto Olavarría
Nickole Marín-Díaz
Ariel Andrés Caviedes
Jessica Hazelton
Teresita Ramos Franco
Hernando Santamaria-García

Frontiers in Aging

doi 10.3389/fragi.2025.1548667

163 views

Original Research

Published on 23 Jun 2025

Intrinsic capacity, functional and psychosocial aspects of older adults participating in a multicomponent physical exercise program

in Healthy Longevity

Sarah Giulia Bandeira Felipe
Clarisse Bielh Printes
Fabiane de Oliveira Brauner
Douglas Katusohi Sato
Rafael Reimann Baptista

Frontiers in Aging

doi 10.3389/fragi.2025.1562383

2,359 views

Review

Published on 23 Jun 2025

Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies

in Aging, Metabolism and Redox Biology

Dalia M. Miller
Stephen L. Archer
Kimberly J. Dunham-Snary

Frontiers in Aging

doi 10.3389/fragi.2025.1585508

1,231 views

Mini Review

Published on 20 Jun 2025

Rapamycin for longevity: the pros, the cons, and future perspectives

in Aging, Metabolism and Redox Biology

Kelley M. Roark
Philip H. Iffland

Frontiers in Aging

doi 10.3389/fragi.2025.1628187

2,508 views

Original Research

Published on 19 Jun 2025

Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers

in Interventions in Aging

Yuan Zhong
Siqi Huang
Meixia Zou
Yiming Chen
Peifeng Shen
Yanan He
Yuanchao Li
Chunlong Liu
Zhibiao Chen

Frontiers in Aging

doi 10.3389/fragi.2025.1592464

1,290 views

Brief Research Report

Published on 17 Jun 2025

Effects of an intergenerational Kindermusik class on stress and affect in older adults with dementia and their caregivers: a pilot study using ecological momentary assessment

in Interventions in Aging

Amber Thro
Phyllis Babcock
T. Lee Covington
Kelly Green
Carol Penney
Jason Fanning
Christina E. Hugenschmidt

Frontiers in Aging

doi 10.3389/fragi.2025.1448293

876 views

Original Research

Published on 17 Jun 2025

Prognostic value of cough force measured by peak expiratory flow in a 4-year longitudinal cohort study of geriatric patients with oropharyngeal dysphagia

in Interventions in Aging

Kiril Stoev
Rainer Wirth
Bendix Labeit
Paul Muhle
Sonja Suntrup-Krueger
Rainer Dziewas
Gero Lueg
Ulrike Sonja Trampisch
Maryam Pourhassan

Frontiers in Aging

doi 10.3389/fragi.2025.1512813

705 views

Original Research

Published on 17 Jun 2025

Normative values to assess functional fitness in older adults in a region of Chile

in Healthy Longevity

Marco Cossio-Bolaños
Rubén Vidal-Espinoza
Luis F. Castelli Correia de Campos
Jose Sulla-Torres
Camilo Urra-Albornoz
Fernando Alvear-Vasquez
Jose Fuentes-Lopez
Marcella Silva Ramos de Lazari
Rossana Gomez-Campos

Frontiers in Aging

doi 10.3389/fragi.2025.1554783

1,221 views

Review

Published on 13 Jun 2025

Assessment of burden and needs of family caregivers for the elderly, a scoping review

in Healthy Longevity

Elodie Le Toullec
Anne Le Gagne
Emilie Leblong
Alain Somat
Patrice Piette

Frontiers in Aging

doi 10.3389/fragi.2025.1578911

1,668 views

Original Research

Published on 12 Jun 2025

Circulatory titin and miR-451a are possible sarcopenia biomarkers in elderly people

in Musculoskeletal Aging

Roberta Mancuso
Lorenzo Agostino Citterio
Simone Agostini
Rossella Miglioli
Riccardo Nuzzi
Laura Antolini
Fabio Trecate
Mario Clerici

Frontiers in Aging

doi 10.3389/fragi.2025.1587438

857 views

Original Research

Published on 10 Jun 2025

Telomere length and COVID-19 disease severity: insights from hospitalized patients

in Molecular Mechanisms of Aging

Stijn Vos
Dries S. Martens
Elien De Waele
Geert Dewyspelaere
Geert Mistiaen
Pieter Goeminne
Tim S. Nawrot

Frontiers in Aging

doi 10.3389/fragi.2025.1577788

1,194 views

Original Research

Published on 10 Jun 2025

EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice

in Musculoskeletal Aging

You-Min Kim
Seung Eon Lee
Yaechan Song
Tae Wook Nam
Jaehoon Lee
Je Kyung Seong
Wan Namkung
Han-Woong Lee

Frontiers in Aging

doi 10.3389/fragi.2025.1564730

911 views

Original Research

Published on 10 Jun 2025

Knowledge, attitude, and practice of osteoporosis prevention in elder patients following lumbar fusion surgery: a cross‐sectional study

in Musculoskeletal Aging

Shaoying Sheng
Manman Wang
Chengfei Yu
Qing Li
Zhan Wang
Yaojing Ma

Frontiers in Aging

doi 10.3389/fragi.2025.1543839

697 views

Original Research

Published on 06 Jun 2025

The curvilinear associations between Life’s Crucial 9 and frailty: cross-sectional study of NHANES 2003 - 2023

in Interventions in Aging

Bo Wang
Chunqi Jiang
Ning Wang
Yinuo Qu
Jun Wang
Guang Zhao
Xin Zhang

Frontiers in Aging

doi 10.3389/fragi.2025.1528338

1,435 views