Frontiers in Bioengineering and Biotechnology

Original Research

Published on 05 Jul 2024

11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells attenuate inflammation in models of sepsis

in Cell and Gene Therapy

Rahul Y. Mahida
Zhengqiang Yuan
Krishna K. Kolluri
Aaron Scott
Dhruv Parekh
Rowan S. Hardy
Michael A. Matthay
Gavin D. Perkins
Sam M. Janes
David R. Thickett

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1422761

3,686 views

Original Research

Published on 18 Jun 2024

Use of CRISPRoff and synthetic Notch to modulate and relay endogenous gene expression programs in engineered cells

in Cell and Gene Therapy

Shuqun Shi
Catherine A. Hamann
Joanne C. Lee
Jonathan M. Brunger

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1346810

2,977 views
2 citations

Original Research

Published on 31 May 2024

Non-viral expression of chimeric antigen receptors with multiplex gene editing in primary T cells

in Cell and Gene Therapy

Dan Cappabianca
Jingling Li
Yueting Zheng
Cac Tran
Kassandra Kasparek
Pedro Mendez
Ricky Thu
Travis Maures
Christian M. Capitini
Robert Deans

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1379900

5,505 views

Review

Published on 24 May 2024

Designing cytochrome P450 enzymes for use in cancer gene therapy

in Cell and Gene Therapy

Saskya E. Carrera-Pacheco
Alexander Mueller
Juan A. Puente-Pineda
Johana Zúñiga-Miranda
Linda P. Guamán

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1405466

12,058 views
7 citations

Review

Published on 23 May 2024

Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications

in Cell and Gene Therapy

André Branco
Janakiram Rayabaram
Cláudia C. Miranda
Ana Fernandes-Platzgummer
Tiago G. Fernandes
Suchitra Sajja
Cláudia L. da Silva
Mohan C. Vemuri

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1380950

5,974 views
2 citations

Systematic Review

Published on 06 May 2024

Evaluating the efficacy of mesenchymal stem cells for diabetic neuropathy: A systematic review and meta-analysis of preclinical studies

in Cell and Gene Therapy

Yu Li
Guangren Yue
Shuying Yu
Xinhao Cheng
Yilin Cao
Ximei Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1349050

2,548 views
2 citations

Original Research

Published on 26 Apr 2024

Cell-free fat extract regulates oxidative stress and alleviates Th2-mediated inflammation in atopic dermatitis

in Cell and Gene Therapy

Zexin Fu
Qinhao Gu
Lu Wang
Lulu Chen
Liuyi Zhou
Qiang Jin
Ting Li
Ye Zhao
Sufan Wu
Xuejiao Luo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1373419

2,695 views
2 citations

Original Research

Published on 17 Apr 2024

Low-intensity pulsed ultrasound promotes the osteogenesis of mechanical force-treated periodontal ligament cells via Piezo1

in Cell and Gene Therapy

Fu Zheng
Tong Wu
Feifei Wang
Huazhi Li
Hongyi Tang
Xinyu Cui
Cuiying Li
Yixiang Wang
Jiuhui Jiang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1347406

4,828 views
9 citations

Original Research

Published on 09 Apr 2024

Harnessing accurate mitochondrial DNA base editing mediated by DdCBEs in a predictable manner

in Cell and Gene Therapy

Jiaxin Qiu
Haibo Wu
Qin Xie
Yuxiao Zhou
Yining Gao
Junbo Liu
Xueyi Jiang
Lun Suo
Yanping Kuang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1372211

2,478 views
4 citations

Original Research

Published on 05 Apr 2024

A novel method for the establishment of autologous skin cell suspensions: characterisation of cellular sub-populations, epidermal stem cell content and wound response-enhancing biological properties

in Cell and Gene Therapy

Michael Peake
Chris Dunnill
Khalidah Ibraheem
Adrian Smith
Douglas J. Clarke
Nikolaos T. Georgopoulos

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1386896

3,085 views
1 citation

Original Research

Published on 21 Mar 2024

Novel bioactive extract from yarrow obtained by the supercritical antisolvent-assisted technique inhibits lipid metabolism in colorectal cancer

in Cell and Gene Therapy

Marta Gómez de Cedrón
Maria de las Nieves Siles-Sanchez
Diego Martín-Hernandez
Laura Jaime
Susana Santoyo
Ana Ramírez de Molina

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1256190

20,477 views
2 citations

Mini Review

Published on 15 Mar 2024

Ethical implications of developing RNA-based therapies for cardiovascular disorders

in Cell and Gene Therapy

Mihaela Hostiuc
Alexandru Scafa
Bogdan Iancu
Daniela Iancu
Oana-Maria Isailă
Oana Mihaela Ion
Ana Stroe
Camelia Diaconu
Dragos Epistatu
Sorin Hostiuc

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1370403

2,988 views
3 citations

Mini Review

Published on 18 Jan 2024

Beyond the promise: evaluating and mitigating off-target effects in CRISPR gene editing for safer therapeutics

in Cell and Gene Therapy

Rui Lopes
Megana K. Prasad

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1339189

12,738 views
22 citations

Original Research

Published on 17 Jan 2024

Genetically engineered CD80–pMHC-harboring extracellular vesicles for antigen-specific CD4+ T-cell engagement

in Cell and Gene Therapy

Irina A. Ishina
Inna N. Kurbatskaia
Azad E. Mamedov
Elena I. Shramova
Sergey M. Deyev
Kamila S. Nurbaeva
Yury P. Rubtsov
Alexey A. Belogurov
Alexander G. Gabibov
Maria Y. Zakharova

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1341685

2,932 views
2 citations

Review

Published on 08 Jan 2024

Advancing genome editing with artificial intelligence: opportunities, challenges, and future directions

in Cell and Gene Therapy

Shriniket Dixit
Anant Kumar
Kathiravan Srinivasan
P. M. Durai Raj Vincent
Nadesh Ramu Krishnan

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1335901

42,076 views
51 citations

Brief Research Report

Published on 20 Dec 2023

Quantitative analysis of preferential utilization of AAV ITR as the packaging terminal signal

in Cell and Gene Therapy

Xin Li
Lohra Mickelle Miller
Matthew Chrzanowski
Jiahe Tian
Martin F. Jarrold
Roland W. Herzog
Weidong Xiao
Benjamin Draper
Junping Zhang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2023.1327433

5,681 views
5 citations