SYSTEMATIC REVIEW article
Front. Cardiovasc. Med.
Sec. Thrombosis and Haemostasis
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1573100
This article is part of the Research TopicExploring the Role of Exercise in Hypertension and Blood Pressure VariabilityView all 6 articles
Effect of HIIT on Hemostasis and Vascular Stiffness: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Provisionally accepted
- 1School of Teacher Education, Hezhou University, Hezhou, China
- 2School of Tourism and Sports Health, Hezhou University, Hezhou, China
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Background: Several small randomized trials have examined the effects of high-intensity interval training (HIIT) on hemostasis and vascular stiffness. However, a clear consensus regarding these effects has not been established. The study is to systematically review the evidence and quantify the impacts of HIIT compared with moderate-intensity continuous training (MICT) or usual care (UC) on hemostasis and vascular stiffness.Methods: Randomized controlled trials (RCTs) exploring the impact of HIIT, MICT, or UC on hemostasis and vascular stiffness were retrieved from PubMed, Embase, Web of Science, and Cochrane databases up to June 10, 2025. A meta-analysis was performed to compare the standardized mean differences (SMD) of changes from baseline to post-intervention in platelet count (PLT), fibrinogen (FIB), D-dimer (D-D), carotid-femoral pulse wave velocity (cfPWV), augmentation index (AIx), AIx normalized to a heart rate of 75 beats·min−1 (AIx@75HR), flow-mediated dilation (FMD), and brachial flow-mediated dilation normalized (nFMD), which were used to evaluate hemostasis and vascular stiffness. The 95% confidence interval(95%CI) was calculated along with the SMD. All analyses were conducted in R (version 4.3.3).Results: Overall, 68 RCTs involving 2,679 patients were included in the analysis. PLT (SMD [95% CI] = -0.26 [-0.51; -0.01]) and FIB (SMD [95% CI] = -0.60 [-1.18; -0.01]) in hemostasis were decreased. Decreased cfPWV (SMD [95% CI] = -0.22 [-0.38; -0.06]), AIx (SMD [95% CI] = -0.16 [-0.30; -0.02]), and AIx@75HR (SMD [95% CI] = -0.35 [-0.61; -0.10]), as well as increased FMD (SMD [95% CI] = 0.37 [0.02; 0.72]) were observed in vascular stiffness. However, there were no notable differences in the D-D and nFMD parameters.Conclusion: HIIT notably improved FIB, cfPWV, AIx, and FMD compared to MICT, or UC. Under certain conditions, PLT and AIx@75HR can also benefit from HIIT. It may be particularly advantageous for patients with cardiovascular disease.
Keywords: HIIT, Hemostasis, Vascular Stiffness, Systematic review, Meta-analysis
Received: 08 Feb 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Jiao, Li, Xie and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qingmei Li, School of Teacher Education, Hezhou University, Hezhou, China
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