ORIGINAL RESEARCH article
Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
This article is part of the Research TopicPrecision Strategies for Atrial Fibrillation: Diagnosis, Risk, and Treatment InnovationsView all 11 articles
Evaluation of the Novel Multi-points Surface Thermometry Cryoballoon in the Treatment of Paroxysmal Atrial Fibrillation
Provisionally accepted
- West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
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Background: Cryoballoon ablation（CBA）is extensively utilized to treat paroxysmal atrial fibrillation (PAF). The Multi-points Surface Thermometry Cryoballoon (CryoMST; Shanghai MicroPort Scientific Corp, China) has recently been introduced. Objectives: To evaluate the clinical efficiency and potential benefits of CryoMST in PAF. Methods: A propensity-score matched study compared 16 patients with PAF undergoing initial CBA with CryoMST against cohorts treated with Arctic Front Advance™ (n=48), radiofrequency ablation (RFA, n=48), and pulsed-field ablation (PFA, n=16). Peri-procedural and 12-month outcome data were compared among the four groups to assess the efficacy and safety of the CryoMST. Results: The CryoMST cohort showed significant reductions in total procedure time (83.00 [Q1, Q3: 75.00, 89.25] vs. 102.00 [Q1, Q3: 85.00, 127.75] min), ablation time (20.00 [Q1, Q3: 18.74, 21.00] vs. 46.00 [Q1, Q3: 38.00, 55.75] min), fluoroscopy time (12.93 [Q1, Q3: 11.15, 16.96] vs. 17.85 [Q1, Q3: 12.35, 23.38] min), fluoroscopy dose (81.80 [Q1, Q3: 69.93, 96.03] vs. 200.00 [Q1, Q3: 134.75, 311.50] mGy), and contrast agent volume (16.00 [Q1, Q3: 11.00, 22.00] vs. 52.50 [Q1, Q3: 45.00, 57.00] ml) compared to the Arctic Front Advance™ group (P < 0.05). CryoMST accurately predicted pulmonary vein occlusion, showing high concordance with pulmonary vein angiograph (sensitivity 89.3%, specificity 100.0%, Kappa value = 0.87, p < 0.001). At 12-month follow-up, rates of arrhythmia recurrence and complications did not differ among the groups. Conclusions: The CryoMST system demonstrates excellent diagnostic accuracy for pulmonary vein occlusion, obviating the need for routine venography. It significantly reduces procedure time, radiation exposure, and contrast use compared to conventional CBA, while maintaining comparable 12-month efficacy and safety to established ablation modalities for PAF.
Keywords: Atrial Fibrillation, Cryoballoon ablation, Multi-points Surface thermometry cryoballoon, Pulmonary vein isolation (PVI), pulsed-field ablation (PFA)
Received: 11 Sep 2025; Accepted: 30 Nov 2025.
Copyright: © 2025 Bai, Jia, Sun, Chan, Wang, Wang, Liu, Shen, Sun and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiayu Sun
Kaijun Cui
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