REVIEW article
Front. Cardiovasc. Med.
Sec. Cardio-Oncology
Cardiotoxicity Associated with Anticancer Therapies for Gynecological Tumors
Liu Yang 1,2
Jixian Liao 1,2
Li Jing 2,1
Zanhong Wang 2,1
1. Third Hospital of Shanxi Medical University, Taiyuan, China
2. Shanxi Bethune Hospital, Taiyuan, China
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Abstract
The continuous advancement in the management of gynecological cancers has contributed to improved patient survival. Nevertheless, cardiovascular toxicity resulting from anti-tumor treatments has emerged as a significant threat to long-term quality of life and non-cancer-related mortality. This review systematically elaborates on the cardiovascular risk of the conventional treatment of gynecological tumor viz chemotherapy, targeted therapy, immunotherapy, endocrine therapy and radiotherapy. The molecular mechanisms of each therapy will also be discussed, including oxidative stress, mitochondrial dysfunction, endothelial injury and immune-mediated inflammation. Additionally, we outline the major risk factors associated with anticancer therapy related cardiovascular toxicity and give an insight into monitoring, diagnosis and management of complications.
Summary
Keywords
Cardio-oncology, cardiovascular toxicity, Gynecologic cancers, Management, Monitoring, risk stratification
Received
03 January 2026
Accepted
09 February 2026
Copyright
© 2026 Yang, Liao, Jing and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Zanhong Wang
Disclaimer
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