REVIEW article
Front. Cardiovasc. Med.
Sec. Heart Failure and Transplantation
Clinical Research Progress of Renal Denervation for Heart Failure Treatment: Current Evidence, Controversies, and Future Directions
Dan Zhang 1
Dong Wang 1
Xiaosu Wang 1
Jingdan Yu 1
Bo Liu 2
1. Department of Clinical Laboratory, Wuhan Asia General Hospital, Wuhan, China
2. Department of Critical Care Medicine, Wuhan Asia General Hospital, Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430056, China, wuhan, China
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Abstract
Heart failure (HF) management continues to evolve, yet morbidity and mortality remain high, particularly among patients with comorbid hypertension and heightened sympathetic activity. In this narrative review, we summarize the mechanistic rationale for renal sympathetic denervation (RDN) in HF, synthesize available clinical evidence across HF phenotypes, and highlight key controversies and future research priorities. We emphasize differential responses across geographic regions and consider how ongoing trials may refine patient selection, procedural strategies, and endpoints. As evidence grows, RDN may become an adjunct device-based therapy for selected HF patients, but definitive outcome trials are still needed before routine implementation.
Summary
Keywords
Catheter-based intervention, Heart Failure, HFPEF, HFREF, Neuromodulation, renal denervation, Sympathetic Nervous System
Received
19 January 2026
Accepted
13 February 2026
Copyright
© 2026 Zhang, Wang, Wang, Yu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Bo Liu
Disclaimer
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