REVIEW article
Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1572909
This article is part of the Research TopicInnovative Tumor Therapies: Targeting Angiogenesis and MetabolismView all 6 articles
Hypoxia-Driven Angiogenesis and Metabolic Reprogramming in Vascular Tumors
Provisionally accepted
- 1Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China, Chengdu, Sichuan Province, China
- 2Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 3NHC Key Laboratory of Chronobiology (Sichuan University), Chengdu, Sichuan Province, China
- 4The Joint Laboratory for Pulmonary Development and Related Diseases, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 5Sichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 6Department of Radiotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, National Clinical Research Center for Geriatrics, Sichuan University, Chengdu, China
- 7Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
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Hypoxia is a hallmark of the tumor microenvironment (TME), and it plays a crucial role in the occurrence and progression in vascular tumors. Under hypoxic conditions, hypoxia-inducible factor 1-alpha (HIF-1α) is stabilized, inducing changes in the expression of various target genes involved in angiogenesis, metabolism, and cell survival. This includes the upregulation of pro-angiogenic factors like VEGF, which promotes the formation of dysfunctional blood vessels, contributing to the worsening of the hypoxic microenvironment. At the same time, hypoxia induces a metabolic shift toward glycolysis, even in the presence of oxygen, supporting tumor cell survival and proliferation by providing necessary energy and biosynthetic precursors. This review discusses the molecular mechanisms by which hypoxia regulates angiogenesis and metabolic reprogramming in vascular tumors, highlighting the intricate link between these processes, and explores potential therapeutic strategies to target these pathways in order to develop effective treatment strategies for patients.
Keywords: vascular tumors, hypoxia, HIF-1α, Angiogenesis, metabolic reprogramming, Tumor Microenvironment
Received: 07 Feb 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Liu, Yu, Liu, Xie, Hu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fan Hu, Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, 610065, Sichuan Province, China
Hanmin Liu, Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China, Chengdu, Sichuan Province, China
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