REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Growth and Division
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1598326
REVIEW OF SENSORY SYSTEMS DEPLOYED BY EPIDERMAL KERATINOCYTES
Provisionally accepted
Mitsuhiro Denda1*
Peter M Elias2- 1Meiji University, Suginami, Tokyo, Japan
- 2University of California, San Francisco, San Francisco, California, United States
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Recent studies have shown that epidermal sensory receptors intercept and direct responses to potentially threatening environmental factors, including shifts in temperature, electric potential, sound, acidity, light, taste, and odor. In addition to stimulating epidermal responses, activation of keratinocytes by these stressors can directly signal the central nervous system. Changes in epidermal permeability barrier homeostasis also depend upon ion dynamics, particularly alterations in intraepidermal gradients of calcium (Ca 2+ ) and pH. The purpose of this review is to update readers about recent advances in the field of cutaneous sensory receptors, focusing upon their roles in mediating not only permeability barrier function, but also whole-body physiology and certain aspects of mental status.
Keywords: keratinocyte, epidermis, sensory receptor, barrier homeostasis, central nervous system, pH 4PDD, 4alpha-phorbol 12,13-didecanoate, ATP, adenosine triphosphate, Ca2+, ionized calcium, Cry J1, Japanese cedar pollen allergen, DMPC, 1,2-Dimyristoyl-snglycero-3-phosphocholine, DOPC, 1,2-Dioleoyl-sn-glycero-3-phosphocholine, NMDA, Nmethyl-D-aspartate
Received: 22 Mar 2025; Accepted: 16 May 2025.
Copyright: © 2025 Denda and Elias. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mitsuhiro Denda, Meiji University, Suginami, 168-8555, Tokyo, Japan
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