ORIGINAL RESEARCH article
Front. Cell Dev. Biol.
Sec. Molecular and Cellular Pathology
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1608647
This article is part of the Research TopicAdvancements in Understanding and Managing Preeclampsia: Exploring Molecular Mechanisms, Biomarkers, and Clinical ImplicationsView all 10 articles
Maternal and fetal outcomes in 151 cases of thrombocytopenia in pregnancy
Provisionally accepted
- 1The First Hospital of China Medical University, Shenyang, China
- 2Shengjing Hospital of China Medical University, Shenyang, China
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Introduction: Thrombocytopenia during pregnancy is one of the important causes of maternal and perinatal mortality. This study aims to retrospectively analyze the clinical data of 151 pregnant patients with thrombocytopenia, in order to help obstetricians better understand the etiology, related risk factors and maternal and fetal outcomes of this disease.Methods: A total of 151 cases of pregnant women with thrombocytopenia were collected. According to the cause of thrombocytopenia, patients were divided into gestational thrombocytopenia (GT) group, hypertensive disorders in pregnancy (HDP) group, immune thrombocytopenia (ITP) group and the other group. According to the degree of thrombocytopenia, patients were divided into mild group, moderate group and severe group. According to different grouping criteria, the clinical characteristics, delivery outcomes and delivery modes, maternal treatments during pregnancy, maternal laboratory indexes, and neonatal birth conditions were compared.Results: Among the 151 patients, the GT group had the largest proportion. Moreover, the ITP group had a higher proportion of skin and mucous membrane bleeding during pregnancy, the smallest gestational age at first diagnosis and the lowest platelet count at first diagnosis. The treatment effect of glucocorticoids alone in the ITP group was not good. The HDP group had a higher neonatal intensive care unit (NICU) transfer rate and the lowest birth weight in newborns. In terms of severity, majority of the patients were in the mild group. The parameters of thromboelastography (TEG) were related to the pre-delivery platelet count of patients in the moderate and severe groups, but not in the mild group.Conclusion: In conclusion, ITP is associated with more severe thrombocytopenia and bleeding, often presenting in the early stage of pregnancy. In the treatment of ITP, the combined use of glucocorticoids and platelet transfusion is recommended. TEG parameter analysis suggests that patients in the moderate and severe groups may have changes in the blood coagulation and fibrinolysis systems. More attention should be paid to the monitoring of the newborns delivered by HDP patients.
Keywords: Pregnancy, Thrombocytopenia, Hypertensive disorders in pregnancy, immune thrombocytopenia, Postpartum Hemorrhage
Received: 09 Apr 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Ibeh, Guo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Feng Guo, Shengjing Hospital of China Medical University, Shenyang, China
Xiuhua Yang, The First Hospital of China Medical University, Shenyang, China
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