Frontiers in Cell and Developmental Biology | Molecular and Cellular Pathology

Original Research

Published on 30 Jan 2026

The D826V point mutation in IREB2 induces lipogenesis in adipose tissues

in Molecular and Cellular Pathology

Yibing Lv
Chunyu Wu
Junyi Xiao
Wenke Yang
Chenyang Wang
Jinming Wang
Jianmei Huang
Zhenglong Guo
Shixiu Liao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1724485

400 views

Original Research

Published on 30 Jan 2026

A switch from α5β1 to αvβ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells

in Molecular and Cellular Pathology

Kassidy L. Johns
Jennifer A. Faralli
Mark S. Filla
Nandini Shah
Kate E. Keller
Donna M. Peters

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1730542

633 views

Review

Published on 30 Jan 2026

HIF-1α at the intersection of hypoxia, ferroptosis-associated stress, and cell death crosstalk in osteomyelitis

in Molecular and Cellular Pathology

Jinglin Li
Fuyin Yang
Xuan Deng
Yang Yu
Xianpeng Huang
Xuxu Yang
Lidan Yang
Tao Zhang
Huazhang Xiong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1672284

627 views

Original Research

Accepted on 29 Jan 2026

Danggui Shaoyao San ameliorates neuroinflammation in a D-galactose-induced Alzheimer's disease rat model by suppressing the JAK2/STAT3 pathway and modulating Th17/Treg -related immune dysregulation

in Molecular and Cellular Pathology

Gangying Fu
Shuyao Tang
Xin Sun
Jiajun Tong
Mengfen Zhou
Ping Li
Pan Meng
Shaowu Cheng
Zhenyan Song

Frontiers in Cell and Developmental Biology

136 views

Original Research

Published on 29 Jan 2026

Comparative performance of GPT-4, GPT-o3, GPT-5, Gemini-3-Flash, and DeepSeek-R1 in ophthalmology question answering

in Molecular and Cellular Pathology

Ping Zhang
Jiaoman Wang
Xinya Hu
Xiaoqing Wang
Xianming Fan
Wei Chi
Weihua Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1744389

923 views

Review

Accepted on 28 Jan 2026

Photobiomodulation for the treatment of knee osteoarthritis: therapeutic effects and molecular mechanism

in Molecular and Cellular Pathology

Peng Xia
Tianxiang Fan
Yangxi Huang
Hanwen Zheng
Ruoxi Ma
Wenjin Zhou
Zhi YAO
Deli Wang
Guoqing Cui
Marco Pang

Frontiers in Cell and Developmental Biology

258 views

Review

Published on 28 Jan 2026

Advances in Traditional Chinese Medicine for chronic obstructive pulmonary disease through multi-omics approaches

in Molecular and Cellular Pathology

Kun Yang
Jun Wang
Yizhao Ma
Hailong Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1761374

769 views

Original Research

Published on 27 Jan 2026

Establishing and validating a predictive model for long-term control outcomes following orthokeratology lenses wear: a five-year cohort study

in Molecular and Cellular Pathology

Zixun Wang
Xiaoling Zhang
Xiaoxue Hu
Hui Miao
Shujun Zhang
Feng Chang
Ruihua Wei
Zheng Guo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1743506

733 views

Original Research

Published on 26 Jan 2026

Quantitative color fundus photography parameters as potential biomarkers of axial length progression: evidence from a machine learning cohort study

in Molecular and Cellular Pathology

Zixun Wang
Feifei Han
Xiaoling Zhang
Jingjie Ding
Jingtao Yu
Xueshuo Xie
Zhiqing Li
Bei Du
Ruihua Wei

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1753213

584 views

Original Research

Published on 23 Jan 2026

VEGF-A isoforms induce the expression of APLN in endothelial cells during human prenatal lung development

in Molecular and Cellular Pathology

Antony Hoarau
Andrew Frauenpreis
Randa Belgacemi
Emma Loeffler
Osshaya Maalouf
Ian A. Glass
Denise Al Alam
Soula Danopoulos

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1729884

864 views

Review

Published on 22 Jan 2026

Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics and computational advances

in Molecular and Cellular Pathology

Chinmay Nitin. Mokal
Mrinmoy Das
Sridhar Hannenhalli
Piyush Agrawal

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1754209

1,223 views

Original Research

Published on 22 Jan 2026

Loss of CAMKK2 and iron-transport proteins—transferrin and its receptor—in the Alzheimer’s disease hippocampus: link to tau pathology

in Molecular and Cellular Pathology

Mohammad Golam Sabbir
Behzad Mansouri
Bram Ramjiawan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2026.1716718

958 views

Mini Review

Accepted on 13 Jan 2026

Phosphatases in Tumor Cell Immune Escape: A Perspective Based on the Camouflage, Coercion, Cytoprotection

in Molecular and Cellular Pathology

Chencheng Zhang
Shudong Zhu

Frontiers in Cell and Developmental Biology

255 views

Review

Published on 12 Jan 2026

Mechanisms and therapeutic prospects of hypoxia-inducible factor 1-alpha in acute kidney injury: a systematic review

in Molecular and Cellular Pathology

Peng Kang
Fan Cheng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1660433

1,122 views

Review

Published on 12 Jan 2026

Proteolytic enzyme models as tunable preclinical platforms for investigating intervertebral disc degeneration

in Molecular and Cellular Pathology

Jan Gewiess
Annamarie D’Intino
Alejandra Santos
Mauro Alini
Andrea J. Vernengo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1683282

787 views

Review

Published on 12 Jan 2026

Impact of follistatin-like 1 on cardiac repair processes following myocardial infarction

in Molecular and Cellular Pathology

Fang He
Xueying Wang
Yongbin Man
Qianqian Xu
Xuejie Yi
Jiao Liu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1746363

912 views

Review

Published on 12 Jan 2026

Progress on the mechanism of Polycystin-1 in bone remodeling

in Molecular and Cellular Pathology

JinShi Guo
GuangXuan Hu
XiaoYing Li
XueJie Yi
Bo Chang
Tao Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1693704

758 views

Original Research

Published on 09 Jan 2026

Development of a novel prognostic model based on TRPM4-Induced sodium overload–mediated cell death in kidney cancer

in Molecular and Cellular Pathology

Wei Wang
Duo Zhao
Zijun Zhou
Bin Chen
Changwen Zhang
E. Du
Longchao Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1755318

1,052 views

Original Research

Published on 08 Jan 2026

Orally administered fluorescein angiography for ultra-wide-field imaging: is a safe and effective modality across different age groups and fundus diseases?

in Molecular and Cellular Pathology

Yuke Ji
Xinya Hu
Yuting Hu
Sisi Lai
Xiaofeng Lu
Xuan Li
Zixiao Liu
Shaochong Zhang
Weihua Yang
Xue Yao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1733128

636 views

Original Research

Published on 07 Jan 2026

Deciphering the immunomodulatory mechanisms of Periplaneta americana L. extract CII-3: insight from integrated metabolomics and network pharmacology

in Molecular and Cellular Pathology

Yilin Wang
Yingxiang Wu
Xi Liu
Zhiyan Lu
Tianqian Li
Yang Jin
Yan Wang
Jiali Zhu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1718560

861 views

Original Research

Accepted on 06 Jan 2026

The Actin Regulator DBNL Is a Critical Mediator of Sympathetic Stress-Induced Bone Loss

in Molecular and Cellular Pathology

Qin Yin
Jun Gu
Ruijun Bai
Kai Zhao
Qiubo Wang
Yu Liu
Haifeng Li

Frontiers in Cell and Developmental Biology

210 views

Mini Review

Published on 06 Jan 2026

A primer on tRNAs, tRNA-m1A58 modification, and tRNA derivatives in T-cell activation

in Molecular and Cellular Pathology

Chuanxiang Zhao
Juxiang Shen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1683213

737 views

Original Research

Published on 06 Jan 2026

Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation

in Molecular and Cellular Pathology

Beijie Qi
Weihan Yu
Hanyi Wang
Yuqi Li
Shuang Deng
Chengqing Yi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1727624

594 views

Review

Published on 05 Jan 2026

The varied functions of the giant muscle scaffold protein obscurin

in Molecular and Cellular Pathology

James Novac Di Paola
Frieder Schöck

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1689326

1,007 views

2,492 articles

articles

The D826V point mutation in IREB2 induces lipogenesis in adipose tissues

A switch from α5β1 to αvβ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells

HIF-1α at the intersection of hypoxia, ferroptosis-associated stress, and cell death crosstalk in osteomyelitis

Danggui Shaoyao San ameliorates neuroinflammation in a D-galactose-induced Alzheimer's disease rat model by suppressing the JAK2/STAT3 pathway and modulating Th17/Treg -related immune dysregulation

Comparative performance of GPT-4, GPT-o3, GPT-5, Gemini-3-Flash, and DeepSeek-R1 in ophthalmology question answering

Photobiomodulation for the treatment of knee osteoarthritis: therapeutic effects and molecular mechanism

Advances in Traditional Chinese Medicine for chronic obstructive pulmonary disease through multi-omics approaches

Establishing and validating a predictive model for long-term control outcomes following orthokeratology lenses wear: a five-year cohort study

Quantitative color fundus photography parameters as potential biomarkers of axial length progression: evidence from a machine learning cohort study

VEGF-A isoforms induce the expression of APLN in endothelial cells during human prenatal lung development

Oral submucosal fibrosis: a comprehensive review on pathogenesis, diagnosis, therapeutics and computational advances

Loss of CAMKK2 and iron-transport proteins—transferrin and its receptor—in the Alzheimer’s disease hippocampus: link to tau pathology

Phosphatases in Tumor Cell Immune Escape: A Perspective Based on the Camouflage, Coercion, Cytoprotection

Mechanisms and therapeutic prospects of hypoxia-inducible factor 1-alpha in acute kidney injury: a systematic review

Proteolytic enzyme models as tunable preclinical platforms for investigating intervertebral disc degeneration

Impact of follistatin-like 1 on cardiac repair processes following myocardial infarction

Progress on the mechanism of Polycystin-1 in bone remodeling

Development of a novel prognostic model based on TRPM4-Induced sodium overload–mediated cell death in kidney cancer

Orally administered fluorescein angiography for ultra-wide-field imaging: is a safe and effective modality across different age groups and fundus diseases?

Deciphering the immunomodulatory mechanisms of Periplaneta americana L. extract CII-3: insight from integrated metabolomics and network pharmacology

The Actin Regulator DBNL Is a Critical Mediator of Sympathetic Stress-Induced Bone Loss

A primer on tRNAs, tRNA-m1A58 modification, and tRNA derivatives in T-cell activation

Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation

The varied functions of the giant muscle scaffold protein obscurin