Frontiers in Cell and Developmental Biology

Original Research

Accepted on 15 Dec 2025

Transcriptome analysis identifies Eda1 variants disrupt FosB-mediated regulation of odontogenic epithelial cell behaviors during dental germ development

in Signaling

Jing Zhang
Xuanting Kong
Yunyun Yuan
Ya Zhao
Yulin Ding
Jiabao Ren
Wenjing Shen

Frontiers in Cell and Developmental Biology

106 views

Editorial

Published on 12 Dec 2025

Editorial: Antioxidants in mitigating oxidative stress-induced damage

in Signaling

Marisol Fernandez-Ortiz
Ramy K. A. Sayed
Russel J. Reiter

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1756697

446 views

Review

Accepted on 10 Dec 2025

Atrial myocyte senescence as a driver of atrial fibrillation: mechanisms and therapeutic implications

in Signaling

Zhaoyang Wei
Zhixiong Li
Nanhu Quan

Frontiers in Cell and Developmental Biology

109 views

Editorial

Published on 10 Dec 2025

Editorial: Ubiquitin proteasome system (UPS) and ubiquitin-independent proteasome-mediated proteolysis (UIPP) crosstalk in development and disease

in Signaling

Michal Sharon
Ralf Stohwasser

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1748172

353 views

Review

Published on 10 Dec 2025

The role of astrocytes in ischemic stroke - mechanisms, functions and treatment

in Signaling

Yunlong Wang
Ding Wang
Dongyu Li
Yuewen Ma

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1700564

302 views

Review

Accepted on 09 Dec 2025

Neoantigens in Cancer Immunoediting: From Mechanisms to Personalized Vaccines in Breast Cancer

in Signaling

Shiyan Zeng
Li Wang
Wanqin Zeng
LEI SUN

Frontiers in Cell and Developmental Biology

108 views

Original Research

Accepted on 05 Dec 2025

XPNPEP2 involved in angiogenesis through the modulation of mitochondrial function via SLC25A6

in Signaling

Chenxi Yang
Yijun Lu
Yu Xia
Bingying Wang
Jie Xu
Zhang Yuchen
Jiaxuan Yan
Min Liu
Ting Chen
Xiaoxu Zhao

Frontiers in Cell and Developmental Biology

207 views

Review

Accepted on 01 Dec 2025

Fibroblast PI3K/AKT Signaling and Extracellular Matrix Homeostasis: Mechanisms, Targets, and Delivery Challenges

in Signaling

Chunyun Fang
Zitao Zeng
Bin Ni
Xiaochun Wen
Zhipeng Fang
Junrong Zou
Guoxi Zhang

Frontiers in Cell and Developmental Biology

214 views

Original Research

Published on 01 Dec 2025

Green-synthesized silver nanoparticles from edible plant extracts ameliorate cadmium chloride-induced hepatorenal and testicular toxicity in rats

in Signaling

Akram Abu-Okail
Abdullah S. M. Aljohani
Ayman M. Mousa
Heba A. S. El-Nashar
Mohamed El-Shazly
Ramy K. A. Sayed
Waleed Al Abdulmonem
Mohamed Farghali
Heba F. Kamaly
Ibrahim M. El-Ashmawy

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1677434

1,061 views

Review

Published on 24 Nov 2025

Role of mitochondria-associated membranes (MAMs) in inflammatory signaling: implications for acute lung injury pathogenesis

in Signaling

Huifeng Qian
Guanguan Qiu
Jianguo Xu
Guoping Zheng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1690934

943 views

Review

Published on 21 Nov 2025

Extracellular vesicles in reproductive medicine: from “animal-led” to “plant-enabled”

in Signaling

Keying Pan
Wenhan Ju
Yue Wang
Qianwen Zhang
Ruyi Wang
Xingyue Jiang
Shuai Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1718643

612 views

Original Research

Published on 19 Nov 2025

New insights into keloid pathogenesis: biomarker potential for CDK7 and DDB2

in Signaling

Weiqiang Zhang
Fujun Wang
Yixun Zhang
Lusheng Xu
Lujia Mao
Xiaoxiang Wang
Ronghua Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1718189

715 views

Original Research

Published on 18 Nov 2025

CLIC1 and CLIC4 demonstrate cell protective antioxidant activity against UV exposure

in Signaling

Khondker Rufaka Hossain
Amani Alghalayini
Daniel R. Turkewitz
Stella M. Valenzuela

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1674374

912 views

Review

Published on 11 Nov 2025

Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis

in Signaling

Lijia Zhang
Rongjiang Xu
Hao Huang
Juan Yang
Changyin Yu
Haiqing Zhang
Zucai Xu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1650909

1,306 views

Original Research

Published on 10 Nov 2025

Reduced levels of nitrated α-synuclein in the protective effect of harpagoside on rotenone-induced cellular models of Parkinson’s disease

in Signaling

Juan Lang
Zhongkui Xiong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1624315

958 views

Mini Review

Published on 07 Nov 2025

Molecular communication from bone to skeletal muscle: an overview

in Signaling

Guobin Li
Mingyan Qi
Yuzhen Wang
Shibin Liang
Huiyun Xu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1715009

1,097 views

Review

Published on 06 Nov 2025

Signaling pathways and advances in targeted therapy for adenomyosis

in Signaling

Yue Li
Hongyu Zhang
Yaoyao Ding
Yiling Zhao
Yufeng Li
Tiansheng Qin

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1685525

1,280 views

Review

Published on 29 Oct 2025

UPRmt-regulated mitokines: novel strategies for myocardial injury repair

in Signaling

Weinan Gao
Jia Liu
Wenda Zhang
Bin Liu
Luyan Shen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1652353

1,478 views

Review

Published on 23 Oct 2025

Non-coding RNAs mediate mechanical load-regulating bone metabolic homeostasis

in Signaling

Ruiqi Huang
Bo Chang
Xuejie Yi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1643255

763 views

Review

Published on 23 Oct 2025

Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges

in Signaling

Fulvio Bonsignore
Sara Pozzi
Erika Aloi
Davide Mazza
Samuel Zambrano

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656051

1,566 views

Original Research

Published on 16 Oct 2025

Petunidin alleviates diabetic nephropathy injury via the inhibition of oxidative stress and ferroptosis through the Keap1/mitoNQO1 pathway

in Signaling

Yuli Qiu
Chao Chen
Xinyan Li
Yiling Chang
Xiaoqin Zou
Xiaopei Yan
Wenjun Mao
Gang Wu
Su Li
Yuqiong Chen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1651382

1,526 views

Editorial

Published on 08 Oct 2025

Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome

in Signaling

Lulong Bo
You Shang
Guochang Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714104

972 views

Review

Published on 03 Oct 2025

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

in Signaling

Yanxian Zhang
Lili Yao
Yongmei Lyu
Zhuqi Tang
Xiaoyu Liu
Xuchu Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631678

1,689 views

Review

Published on 25 Sep 2025

Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis

in Signaling

Yan Wu
Donghao Gan
Zhikang Liu
Daodi Qiu
Guoqing Tan
Zhanwang Xu
Haipeng Xue

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1670716

4,973 views
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