Frontiers in Cell and Developmental Biology

Review

Accepted on 09 Sep 2025

Osteocytes: Master Orchestrators of Skeletal Homeostasis, Remodeling, and Osteoporosis Pathogenesis

in Signaling

Yan Wu
Donghao Gan
Zhikang Liu
Daodi Qiu
Guoqing Tan
Zhanwang Xu
Xue Haipeng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1670716

569 views

Original Research

Published on 04 Sep 2025

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

in Signaling

Xiaoying Niu
Xinxin Zhang
Zhongyi Li
Wen Tian

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620648

1,228 views

Review

Published on 03 Sep 2025

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

in Signaling

Boming Peng
Min Huang
Jianquan Zhang
Yang Xiang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656019

1,269 views

Original Research

Published on 26 Aug 2025

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

in Signaling

Qing Ge
Yaokun Zou
Huizhi Deng
Zhe Yang
Linhu Ge
Jieying Huang
Jianqiang Cai
Liping Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1632882

1,269 views

Review

Published on 26 Aug 2025

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

in Signaling

Liangzi Yin
Chenglin Sun
Junjie Zhang
Yan Li
Yansheng Wang
Lunhao Bai
Zeming Lei

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1639430

1,247 views

Review

Published on 22 Aug 2025

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

in Signaling

Zheng Jin
Zhenhua Zhu
Jun Chen
Xiaopeng Jing
Jie Tan
Ji Zeng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1665313

712 views

Original Research

Published on 20 Aug 2025

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

in Signaling

Tainara Cristina Michelotti
Valérie Lamothe
Frédéric Jean-Alphonse
Eric Reiter
Muriel Bonnet
Guillaume Durand

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1645031

1,021 views

Original Research

Accepted on 18 Aug 2025

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-a-driven ICAM-1 expression

in Signaling

John Lin
Lyvia Fourcade
Lucie Roussel
Matthew Marabella
Dao Nguyen
Simon Rousseau

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1566482

156 views

Review

Published on 15 Aug 2025

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

in Signaling

Jinghui Zhai
Yue Zhang
Shuyue Ma
Yingli Zhang
Miao Jin
Huiyu Yan
Sixi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1604539

992 views

Opinion

Published on 15 Aug 2025

RAC1 signaling in prostate cancer: VAV GEFs take center stage

in Signaling

Mariana Cooke
Nahuel Peinetti
Marcelo G. Kazanietz
Kerry L. Burnstein

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1658639

858 views

Original Research

Published on 12 Aug 2025

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis

in Signaling

Mingxing Wen
Xinyu Zhang
Litao Tong
Yuhui Chen
Zhengjie Li
Yichen Wang
Can Liu
Jinwei Zhang
Liangpeng Ge
Jing Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620369

824 views

Editorial

Published on 12 Aug 2025

Editorial: Deciphering signaling pathway interactions in tissue homeostasis

in Signaling

John T. Hancock

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1677790

526 views

Correction

Published on 08 Aug 2025

Correction: KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

in Signaling

Valentina Rapozzi
Clara Comuzzi
Eros Di Giorgio
Luigi E. Xodo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661525

603 views

Review

Published on 08 Aug 2025

The multifaceted impact of physical exercise on FoxO signaling pathways

in Signaling

Wei Liu
Pengjun Meng
Zhi Li
Yifei Shen
Xin Meng
Shen Jin
Mengdi Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1614732

1,568 views

Original Research

Published on 07 Aug 2025

Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease

in Signaling

Juan Lang
Zhongkui Xiong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631652

871 views

Original Research

Published on 05 Aug 2025

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal

in Signaling

Marius W. Baeken
Ankush Borlepawar
Philipp Kötzner
Holger Richly
Christian Behl
Bernd Moosmann
Parvana Hajieva

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1608400

2,026 views