Frontiers in Cell and Developmental Biology

Editorial

Published on 08 Oct 2025

Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome

in Signaling

Lulong Bo
You Shang
Guochang Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714104

277 views

Review

Published on 03 Oct 2025

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

in Signaling

Yanxian Zhang
Lili Yao
Yongmei Lyu
Zhuqi Tang
Xiaoyu Liu
Xuchu Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631678

472 views

Review

Accepted on 02 Oct 2025

Linking Signaling Dynamics and Cell Fate Decisions Through Single-Cell Imaging: Evidence and Challenges

in Signaling

Fulvio Bonsignore
Sara Pozzi
Erika Aloi
Davide Mazza
Samuel Zambrano

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656051

285 views

Review

Accepted on 25 Sep 2025

UPRmt-Regulated Mitokines: Novel Strategies for Myocardial Injury Repair

in Signaling

Jia Liu
Wenda Zhang
Weinan Gao
Luyan Shen
Bin Liu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1652353

367 views

Review

Published on 25 Sep 2025

Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis

in Signaling

Yan Wu
Donghao Gan
Zhikang Liu
Daodi Qiu
Guoqing Tan
Zhanwang Xu
Haipeng Xue

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1670716

1,611 views

Original Research

Accepted on 24 Sep 2025

Petunidin alleviates diabetic nephropathy injury via the inhibition of oxidative stress and ferroptosis through the Keap1/mitoNQO1 pathway

in Signaling

Yuli Qiu
Yuqiong Chen
Chao Chen
Xinyan Li
Yiling Chang
Xiaoqin Zou
Xiaopei Yan
Wenjun Mao
Gang Wu
Su Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1651382

440 views

Original Research

Published on 23 Sep 2025

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression

in Signaling

John Lin
Lyvia Fourcade
Lucie Roussel
Matthew Marabella
Julie Bérubé
Dao Nguyen
Simon Rousseau

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1566482

751 views

Original Research

Published on 04 Sep 2025

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

in Signaling

Xiaoying Niu
Xinxin Zhang
Zhongyi Li
Wen Tian

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620648

2,063 views

Review

Published on 03 Sep 2025

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

in Signaling

Boming Peng
Min Huang
Jianquan Zhang
Yang Xiang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656019

2,177 views

Original Research

Published on 26 Aug 2025

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

in Signaling

Qing Ge
Yaokun Zou
Huizhi Deng
Zhe Yang
Linhu Ge
Jieying Huang
Jianqiang Cai
Liping Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1632882

1,588 views

Review

Published on 26 Aug 2025

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

in Signaling

Liangzi Yin
Chenglin Sun
Junjie Zhang
Yan Li
Yansheng Wang
Lunhao Bai
Zeming Lei

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1639430

1,585 views

Review

Published on 22 Aug 2025

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

in Signaling

Zheng Jin
Zhenhua Zhu
Jun Chen
Xiaopeng Jing
Jie Tan
Ji Zeng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1665313

919 views

Original Research

Published on 20 Aug 2025

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

in Signaling

Tainara Cristina Michelotti
Valérie Lamothe
Frédéric Jean-Alphonse
Eric Reiter
Muriel Bonnet
Guillaume Durand

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1645031

1,211 views

Review

Published on 15 Aug 2025

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

in Signaling

Jinghui Zhai
Yue Zhang
Shuyue Ma
Yingli Zhang
Miao Jin
Huiyu Yan
Sixi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1604539

1,282 views

Opinion

Published on 15 Aug 2025

RAC1 signaling in prostate cancer: VAV GEFs take center stage

in Signaling

Mariana Cooke
Nahuel Peinetti
Marcelo G. Kazanietz
Kerry L. Burnstein

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1658639

1,037 views

Original Research

Published on 12 Aug 2025

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis

in Signaling

Mingxing Wen
Xinyu Zhang
Litao Tong
Yuhui Chen
Zhengjie Li
Yichen Wang
Can Liu
Jinwei Zhang
Liangpeng Ge
Jing Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620369

1,023 views