ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1514315
This article is part of the Research TopicDeciphering Microbial Metabolites: Their Impact on Gastrointestinal and Metabolic HealthView all 8 articles
Characteristics of metabolites analysis for patients with granulomatous lobular mastitis
Provisionally accepted
- 1Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- 2Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
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Background: Granulomatous lobular mastitis (GLM) is a type of non-puerperal mastitis (NPM) associated with autoimmune factors. Previous studies suggest that gut microbiota dysbiosis may play a role in the pathological process of GLM; however, the specific role of gut microbiota metabolites in this process remains unclear. Therefore, this study aimed to investigate the gut metabolic characteristics of SCFA in patients with GLM, a type of NPM. Methods: Stool samples were collected from 35 patients with GLM and 26 healthy control (HC) subjects. These samples underwent targeted metabolomic analysis to measure short-chain fatty acid (SCFAs) and 16s rRNA high-throughput sequencing to assess gut microbiota composition and differences between the groups.Results: Gas chromatography-mass spectrometry(GC-MS) analysis revealed that the content of SCFA-butyric acid in the feces of patients with GLM was higher than that in the HC group. Notably, significant differences in metabolic pathways were observed between the HC and GLM groups.High-throughput sequencing results showed that the richness and diversity of gut microbiota in patients with GLM were significantly lower than those in healthy individuals. In addition, 53 bacterial species were found to differ significantly in abundance between the two groups. Moreover, the level of isohexanoic acid in the feces of patients with GLM with recurrence disease was significantly higher than that of patients without recurrence. Conclusions: Patients with GLM exhibit disturbances in gut butyric acid metabolism and significant differences in gut microbiota structure compared to healthy individuals.
Keywords: Granulomatous lobular mastitis, short-chain fatty acid, Gut Microbiota, nonpuerperal mastitis, metabolite
Received: 29 Nov 2024; Accepted: 20 May 2025.
Copyright: © 2025 Dai, Zhou, Wu and Liao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jingjing Wu, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
Mingjuan Liao, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
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