ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Antibiotic Resistance and New Antimicrobial drugs
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1515537
This article is part of the Research TopicNew Clinically Important Candida species and other Emerging Yeasts: Navigating New Challenges in Antifungal Resistance, Diagnosis and TreatmentView all articles
Bacillus velezensis NC-B4 as a Promising antifungal agent for Biocontrol of Candida auris
Provisionally accepted
- 1Jiangxi Provincial People's Hospital, Nanchang, China
- 2Jiangxi Agricultural University, Nanchang, Jiangxi, China
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Candida auris, known as the "super fungus", is commonly existed in hospital. The treatment of C. auris infection is difficult for its multi-drug resistance and difficult to accurately detect. The use of synthetic antibacterial agents has caused major problems such as drug-resistance and environment pollution and negatively affects non-target species. Microbial biocontrol agents (probiotics) are needed for fungal infection. Bacillus and related genera produce a variety of bioactive substances.As probiotics, it has been widely studied in the field of medicine and is a novel microbial factor for biological control. We isolated B. velezensis NC-B4 and identified by phylogenetic analysis and physiological and biochemical characteristics. B. velezensis NC-B4 showed enzyme activity and antimicrobial effects against human pathogenic fungi by inhibiting the growth of Candida auris, Cryptococcus neoformans, Candida albicans and mycelial fungus. B. velezensis NC-B4 has a protective effect against the toxicity of Candida auris to A549 cells. The complete genome of B. velezensis NC-B4 was 3.93 Mb with a 46.5% G+C content and possessed the macrolactin H, bacillaene, fengycin, difficidin, bacillibactin and bacilysin biosynthesis cluster, which known as key factors in biological control.
Keywords: Antifungal activity, Bacillus velezensis NC-B4, biological control, Candida auris, genome-sequence analysis
Received: 23 Oct 2024; Accepted: 04 Aug 2025.
Copyright: © 2025 Chunxi, Chaoyu, Yanru and Zimei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yang Chunxi, Jiangxi Provincial People's Hospital, Nanchang, China
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