REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1526063
This article is part of the Research TopicThe Role of Gut Microbes and Their Metabolites in Immune-related Diseases-Volume IIView all 17 articles
Impact of Gut Microbiota on Endometriosis: Linking Physical Injury to Mental Health
Provisionally accepted
- The First People’s Hospital of Yunnan Province, Kunming, China
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Endometriosis is widely recognized as a chronic, inflammatory, and heterogeneous condition that can manifest in various anatomical locations within females. It is marked by estrogen-driven cycles of bleeding, cell proliferation, and fibrosis involving ectopic endometrial glands and stroma cells located outside the uterus. The limited understanding of its etiology and complex pathogenesis has created obstacles in achieving early diagnosis and developing effective treatments with minimal side effects. Consequently, endometriosis requires more in-depth research to unravel its pathogenesis. The gut microbiota, a key player in chronic diseases, significantly influences bodily metabolism and immune regulation. Emerging evidence links the gut microbiota to inflammation, estrogen metabolism, and immune responses-key factors in the onset and progression of endometriosis. This review examines the various mechanisms through which endometriosis and the gut microbiota interact, aiming to inspire new strategies for preventing and early treating endometriosis.
Keywords: Endometriosis, Gut Microbiota, immune dysfunction, Estrobolome, complement system
Received: 11 Nov 2024; Accepted: 09 Jun 2025.
Copyright: © 2025 Li, Xu, Qian, Ling and Jing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuanyue Li, The First People’s Hospital of Yunnan Province, Kunming, China
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