REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1546627
This article is part of the Research TopicInteractions between tissues and kingdoms and interplay with environmental factors: impact on metabolic health and diseasesView all 6 articles
The role of probiotics in adolescents' obesity
Provisionally accepted
- School of Physical Education and Health, Chongqing University of International Business and Economics, Chongqing, China
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The prevalence of adolescent obesity continues to rise globally, posing significant public health challenges by affecting both physical and psychological wellness and increasing the risk of metabolic diseases in adulthood. Probiotics may influence obesity through various mechanisms, including restoring gut microbiota balance, reducing chronic inflammation, modulating lipid metabolism, aiding in weight control, and improving metabolic health. This review aims to explore the mechanisms by which probiotics act as key modulators of obesity and summarize current findings from clinical trials involving probiotics in adolescent obesity. The large-scale, multicenter, long-term follow-up randomized controlled trials are necessary to determine the optimal probiotics strains, dosages, and treatment durations, as well as to assess their long-term efficacy and safety in the future. Through such rigorous studies, probiotics have the potential to become a safe, effective, and accessible adjunct in the comprehensive management of adolescent obesity, offering a more holistic approach to health management for this population.
Keywords: Probiotics, Obesity, adolescence, Gut Microbiota, Lipid Metabolism
Received: 17 Dec 2024; Accepted: 12 Jun 2025.
Copyright: © 2025 Chen, Jia and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yong Jia, School of Physical Education and Health, Chongqing University of International Business and Economics, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.