ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1575108
This article is part of the Research TopicNew Perspectives on Bioelectrical Impedance Analysis in Musculoskeletal AgingView all articles
Influence of Helicobacter Pylori Infection on Chinese Adult Males' Body Muscle Mass: A Cross-Sectional and Cohort Analysis
Provisionally accepted
- Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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Aim:Helicobacter pylori (HP) infection may cause many disorders outside the digestive system, although research on the association between HP infection and muscular atrophy among males is limited. This study aimed to examine the influence of HP infection on adult Chinese males' body muscle mass using a cross-sectional and cohort analysis.Methods: A total of 8110 Chinese adult males were enrolled in the study. HP infection was assessed using the C13 breath test. Using bioelectrical impedance analysis (BIA), body muscle mass was detected and total muscle mass, total skeletal muscle mass, and appendicular skeletal muscle mass index (ASMI) were recorded.Univariate and multivariate linear regression analyses were conducted to identify the factors associated with body muscle mass.Results: Subjects with HP infection had a lower total muscle mass, total skeletal muscle mass, and ASMI compared with those without HP infection (P < 0.01).Univariate and multivariate linear regression analyses demonstrated that HP infection was an independent risk factor of total muscle mass, total skeletal muscle mass, and ASMI (P < 0.01); this association persisted when subjects were divided into young, middle-aged, and elderly according to age (P < 0.01). A subsequent cohort study confirmed that persistent HP infection accelerated the pathological process of muscle decline (P < 0.01).Chinese males, long-term HP infection may accelerate this pathological progression.
Keywords: Helicobacter pylori, bioelectrical impedance analysis, Body muscle mass, Adult Chinese males, A Cross-Sectional syudy, Cohort analysis
Received: 11 Feb 2025; Accepted: 08 May 2025.
Copyright: © 2025 Liu, Li, Nie, Li, Cheng, Su, Yang and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jian-Wei Gu, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
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