ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Microbiology
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1581545
This article is part of the Research TopicA One Health Approach to Infection Prevention and Antimicrobial ResistanceView all articles
Impact of Free Provision of Disinfectant Wipes Combined with Bundle Management on the Prevention of Multi-Drug Resistant Organism Infections in the Respiratory and Intensive Care Unit (RICU)
Provisionally accepted
- 1The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
- 2The Yiluo Hospital of Luoyang, The Teaching Hospital of Henan University of Science and Technology, Luoyang, China
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Objective: To explore the role of free provision of disinfectant wipes combined with bundle management in preventing Multi-Drug Resistant Organism (MDRO) infections in the Respiratory and Intensive Care Unit (RICU).This study included patients admitted to the RICU between January 2022 and June 2023 (control group) and from July 2023 to June 2024 (intervention group), all of whom met the inclusion criteria. The control group received standard bundle management measures, while the intervention group received unlimited use of disinfectant wipes combined with bundle management. The MDRO discovery rates and hospital-acquired infection incidence rates were compared between the two groups to assess the impact of free disinfectant wipe provision on MDRO infection prevention in the RICU. Results: There were no significant differences between the two groups in terms of patient age and baseline characteristics, except for Sex and the proportion of patients with chronic respiratory diseases. Notably, the MDRO discovery rate, MDRO infection rate, and hospital-acquired infection incidence were all significantly lower in the intervention group compared to the control group (MDRO discovery rate: 35.2% vs 45.9%, P<0.001; MDRO infection rate: 0.8% vs 3.5%, P = 0.003; hospital-acquired infection rate: 1.5% vs 3.52%, P=0.030). However, the intervention group had more percentage of patients receiving mechanical ventilation and longer ICU stay (P < 0.05). Furthermore, in-hospital mortality was lower in the intervention group (19.5% vs 13.5%, P < 0.05).The combined intervention of unlimited use of disinfectant wipes with bundle management significantly reduced MDRO hospital-acquired infection rates and in-hospital mortality in the RICU, demonstrating its effectiveness in infection prevention.
Keywords: Respiratory and Intensive Care Unit, Multi-drug resistant organisms, Disinfectant wipes, Bundle Management Measures, Prevention. (Min.5-Max. 8)
Received: 22 Feb 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Wang, Liang, Gao, Ma, Huang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shen-Shen Huang, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
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