ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1593581
This article is part of the Research TopicImpact of Gut Probiotic Metabolites on Human Metabolic DiseasesView all 4 articles
Rosuvastatin ameliorates obesity-associated insulin resistance in highfat diet-fed mice by modulating the gut microbiota and gut metabolites
Provisionally accepted
- Inner Mongolia Medical University, Hohhot, China
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Metagenomics and metabolomics were used to analyze the main species and metabolic pathways involved in intestinal microbes while improving insulin resistance in mice with rosuvastatin in this study. C57BL/6J male mice fed a high-fat diet were used to establish the insulin resistance (IR) mouse model. Rosuvastatin (RSV) was then administered for 8 weeks. Metagenomics and metabolomics were utilized to analyze the microbial composition and short-chain fatty acid metabolites in intestinal feces of mice. It was observed that insulin-resistant mice showed significant improvement in insulin resistance following treatment with RSV. In comparison to the HFD group, specific bacterial strains were significantly increased, and the levels of butyric acid, caproic acid, and isovaleric acid among the short-chain fatty acids were notably elevated in the RSV group. Through KEGG enrichment analysis, 19 dominant strains and 15 key enzymes involved in butyric acid metabolism were identified. The results suggested that IR mice might enhance insulin sensitivity by promoting butyric acid synthesis via intestinal microbes following RSV treatment.
Keywords: Insulin Resistance, Rosuvastatin, Metagenome, Metabolome, Butyric Acid
Received: 14 Mar 2025; Accepted: 03 Jun 2025.
Copyright: © 2025 Yao, Xue, Jia, Li, Zhang, Yuan, Xue and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hong Yuan, Inner Mongolia Medical University, Hohhot, China
Huiting Xue, Inner Mongolia Medical University, Hohhot, China
Ruiping Hu, Inner Mongolia Medical University, Hohhot, China
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