ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1593610
This article is part of the Research TopicUnraveling Diarrheic Virus-Host Interactions: Mechanisms and ImplicationsView all 5 articles
Genetic Diversity of Norovirus in Shenzhen Based on Continuous Surveillance from 2016 to 2022
Provisionally accepted
Xin Wang1
Wanqiu Liu2
Mingda Hu1
Hui Ma3Yaqing He4
Boqian Wang1Kexin Li5Rui Zhang5Jingjing Fu6
Hailong Zhang4Long Chen4Xinru Zhao5Buaijier Aimaiti5
Hongbin Song7
Hongguang Ren1*Xiaofeng Hu7- 1Beijing Institute of Biotechnology, Beijing, Beijing, China
- 2University of South China, Hengyang, China
- 3People's Liberation Army General Hospital, Beijing, Beijing Municipality, China
- 4Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China
- 5China Medical University, Shenyang, Liaoning Province, China
- 6Southern Medical University, Guangzhou, Guangdong, China
- 7Chinese PLA Center for Disease Control and Prevention, Beijing, China
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As a key pathogen of acute gastroenteritis, norovirus poses a significant burden on both the economy and public health. Based on local sentinel hospitals, this study conducted continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, and analyzed the epidemic characteristics and genetic diversity of norovirus in Shenzhen, in the backdrop of global sequence data. We described the demographic, spatial, and temporal distribution of norovirus, conducted phylogenetic analysis, and compared genotype dynamics percentages across geographic levels. We also evaluated mutations on protein stability and conducted recombination analysis. Our study revealed that norovirus primarily infected infants under 3 years old, with the epidemics occurring in winter and concentrated in developed districts. Phylogenetic analysis and genotype comparisons at different geographical levels revealed both similarities and differences in the evolutionary patterns of various genotypes. We investigated the mutations of VP1 based on the protein structure of GⅡ.4_Sydney[P31] to explore the evolutionary trends of key genotypes. Additionally, recombination analysis identified critical breakpoints and fragments for norovirus. These findings offer important insights tointo the global evolution and transmission of norovirus and serve as a reference for future research and vaccine development.
Keywords: Norovirus, genetic diversity, Mutation, recombination, Shenzhen
Received: 14 Mar 2025; Accepted: 28 May 2025.
Copyright: © 2025 Wang, Liu, Hu, Ma, He, Wang, Li, Zhang, Fu, Zhang, Chen, Zhao, Aimaiti, Song, Ren and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongguang Ren, Beijing Institute of Biotechnology, Beijing, Beijing, China
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