ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Parasite and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1600686
This article is part of the Research TopicParasite-Induced Liver Diseases Volume IIView all articles
TIM4+macrophages suppress the proinflammatory response to maintain the chronic alveolar echinococcosis infection
Provisionally accepted
Liang Wang1Yumei Liu2Jiajun Li3Xuan Zhou3Maidinaimu • Aibibula3Xue Zhang4Hui Zhao4Jinping Zhou3
Fengming Tian3*
Xiumin Ma3- 1Fifth Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Region, China
- 2Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, China
- 3Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China
- 4First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Region, China
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Highlights： 1. Tim-4 emerged as athe potential target associated with E. multilocularis infection in patients with hepatic AE.2. Tim-4 attenuated the predominant proinflammatory response, thereby facilitating immune evasion by E. multilocularis. Notably, inhibition of Tim-4 in macrophages not only restored inflammatory balance but also significantly reversed hepatic fibrotic progression.Tim-4 suppressed the dominant expression of proinflammatory response to promote parasite immune escape. And inhibition of Tim-4 expression on macrophages even reversed the level of liver fibrosis.
Keywords: Echinococcus multilocularis, TIM-4, parasite infection immunity, macrophage, liver fibrosis
Received: 26 Mar 2025; Accepted: 14 May 2025.
Copyright: © 2025 Wang, Liu, Li, Zhou, Aibibula, Zhang, Zhao, Zhou, Tian and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fengming Tian, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, China
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