REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Microbes and Innate Immunity
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1604831
The role of innate immune system in respiratory viral infection related asthma
Provisionally accepted
- 1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China
- 2Shanghai University of Traditional Chinese Medicine, Shanghai, Shanghai Municipality, China
- 3Key Laboratory of Organ Regeneration and Transplantation, First Hospital of Jilin University, Changchun, Jilin Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The association between viral infections and asthma has garnered significant attention in recent years. Accumulating evidence suggests that viral infections can trigger asthma exacerbations, while asthma may also influence the susceptibility to viral infections, thereby creating a cycle of worsening symptoms and recurrent asthma attacks. Given that asthma is predominantly driven by Type 2 immune responses and viral infections are typically associated with Type 1 immune responses, the innate immune cells and cytokines that participate in both conditions appear to be the critical bridge connecting these two processes. In particular, innate immune cells play a pivotal role in modulating the immune response at the interface of viral infections and asthma. In this review, we summarize the key innate immune cells and cytokines involved in viral infections and asthma, highlighting their immunoregulatory mechanisms. We aim to provide novel perspectives and potential therapeutic directions for the clinical management of recurrent asthma attacks induced by viral infections.
Keywords: asthma, viral infection, innate immune cells, cytokines, recurrent asthma attacks AHR, airway hyperresponsivenessairway hyperresponsiveness, BECs, bronchial epithelial cells, CDHR3, cadherin related family member 3, COVID-19, coronavirus disease, CXCL, C-2 / 29 X-C motif chemokine, DC, dendritic cells, dsRNA, double-stranded RNA, EMT, epithelial-tomesenchymal transition
Received: 02 Apr 2025; Accepted: 06 Jun 2025.
Copyright: © 2025 Wu, Huang, Yao and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenbo Yao, Key Laboratory of Organ Regeneration and Transplantation, First Hospital of Jilin University, Changchun, 130021, Jilin Province, China
Xue Zheng, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, 200071, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.