REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1606317
This article is part of the Research TopicExploring the Immune-Metabolic Network in DiabetesView all 11 articles
Immunometabolic Reprogramming in Diabetic Osteomyelitis: From Mechanisms to Therapeutics
Provisionally accepted
- Liaoning University of Traditional Chinese Medicine, Shenyang, China
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Diabetes mellitus (DM) is a globally prevalent metabolic disorder characterized by impaired immune function due to poor glycaemia control, significantly increasing the risk of osteomyelitis. The occurrence of bone infection not only compromises patients' quality of life but also poses substantial challenges in clinical management. Recent studies have identified immunometabolic reprogramming as a pivotal player in the pathogenesis and progression of diabetic osteomyelitis. This reprogramming not only disrupts immune cell functionality but also modulates the local microenvironment, thereby impairing bone repair processes. Although preliminary research has explored the underlying mechanisms, a comprehensive understanding of the precise role of immunometabolic reprogramming and its potential therapeutic targeting in diabetic osteomyelitis remains elusive. This review synthesizes current advances in immunometabolic reprogramming within diabetic osteomyelitis, elucidates its biological mechanisms, and proposes novel intervention strategies to inform clinical practice and inspire future therapeutic development.
Keywords: Diabetes Mellitus, Osteomyelitis, immunometabolic reprogramming, mechanisms, Therapeutics
Received: 05 Apr 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Zhang, Fu, Zhou, Wang, Ye, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Zhang, zh18004018436@163.com
An-na Wang, 472038564@qq.com
Jun-tong Liu, wojiaoliujuntong@163.com
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