REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Oral Microbes and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1611097
This article is part of the Research TopicImpact of oral and gut microbiome on health and diseasesView all 18 articles
Periodontal disease and chronic kidney disease: mechanistic insights and novel therapeutic perspectives
Provisionally accepted
- 1Jilin University, Changchun, China
- 2Sichuan University, Chengdu, Sichuan Province, China
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Periodontal disease (PD) is one of the most common chronic diseases of the oral cavity, and it usually refers to chronic inflammatory diseases caused by the infection of pathogenic microorganisms in the oral cavity. PD mainly affects the tissues around the teeth, causing inflammation of the gums and periodontium, destroying the alveolar bone, and even leading to tooth loosening. Many studies have shown that PD is not only limited to oral health but is also associated with diseases of multiple systems throughout the body. In recent years, more and more studies have focused on the interaction between PD and urologic diseases, especially chronic kidney disease (CKD). PD is also a typical oral disease frequently observed in patients with kidney disease. This paper reviews the potential link between PD and CKD and discusses the interaction's pathologic mechanisms and clinical implications. In addition, this review aims to identify possible pathogenic mechanisms and suggest potential ways to target PD to prevent and treat CKD. This would lead to better treatment options to delay the progression of CKD.
Keywords: Periodontal disease, Oral microbiota, Chronic Kidney Disease, systemic inflammation, Inflammatory factors, Reactive Oxygen Species, therapy
Received: 13 Apr 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Li, Cao, Zhang, Wang, Huang, Wang, Wei and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Wei, Jilin University, Changchun, China
Gang Wang, Jilin University, Changchun, China
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