REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Antibiotic Resistance and New Antimicrobial drugs
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1614232
This article is part of the Research TopicPerspectives in Clinical Microbiology for Combating Multi-drug Resistant Bacterial Infections: 2024/2025View all 10 articles
A One Health Perspective on Multidrug-Resistant Bacterial Infections: Integrated Approaches for Surveillance, Policy and Innovation
Provisionally accepted
- 1University of Ibadan, Ibadan, Nigeria
- 2Department of Microbiology, Faculty of Science, University of Ibadan, Ibadan, Oyo, Nigeria
- 3Edo State Ministry of Agriculture and Food Security, Benin City, Nigeria
- 4Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria
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Multidrug-resistant (MDR) bacterial infections represent a growing global health emergency, driven by interconnected human, animal, and environmental factors. This review adopts a One Health perspective to explore the transmission dynamics, operational integration, and innovative responses to antimicrobial resistance (AMR). Case studies from China, India, Nigeria, Thailand, and Brazil underscore the effectiveness of regulatory reforms, surveillance networks, and public engagement campaigns. Notably, Artificial Intelligence (AI) is transforming MDR management through real-time diagnostics and resistance prediction, though ethical concerns and infrastructure deficits in Low-and Middle-Income Countries (LMICs) remain barriers. Community-led initiatives, gender-sensitive education, and policy reforms are vital to curbing misuse and closing equity gaps. Despite successes, challenges such as fragmented governance, underfunded labs, and limited longitudinal research persist. A proactive, integrated One Health approach-linking clinical, environmental, and policy actions-is essential for reducing MDR burden. Investment in intersectoral surveillance, equitable AI deployment, and community empowerment is imperative for safeguarding antibiotics and ensuring global health resilience.
Keywords: Multidrug-resistant (MDR) bacteria, One Health, Antimicrobial stewardship, environmental reservoirs, AI technologies, inter-sectoral collaborations, Zoonotic MDR outbreaks, Global Health Table 1: Literature Search Strategy Component Details Databases PubMed
Received: 22 Apr 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Ohia, Falodun, Adebudo and Bakarey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chinenyenwa M.D. Ohia, University of Ibadan, Ibadan, Nigeria
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