ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Veterinary and Zoonotic Infection
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1615007
This article is part of the Research TopicParasites at the One Health Interface, Volume IIView all articles
Diagnostic Utility of Hematological and Biochemical Markers for Cystic Echinococcosis in Tibetan Patients of Sichuan, China
Provisionally accepted
- 1University of Electronic Science and Technology of China, Chengdu, China
- 2Ganzi Tibetan Autonomous Prefecture People's Hospital, Ganzi, China
- 3West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
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Objective: This hospital-based case-control study aims to evaluate hematological and biochemical markers for the diagnosis of cystic echinococcosis (CE) in the Tibetan population of Sichuan. Methods: This study involved 83 patients diagnosed with CE and 45 healthy controls. Diagnosis of CE was confirmed through antibody and imaging tests, followed by an analysis of differences in blood and biochemical markers. Results:(1) Patients with CE displayed significant abnormalities in blood and biochemical indicators compared to healthy subjects, including increased levels of platelet count, eosinophil percentage, basophil percentage, prothrombin time, fibrinogen, activated partial thromboplastin time, total bilirubin, direct bilirubin, γ-glutamyltransferase, aspartate aminotransferase, and alkaline phosphatase. Conversely, there was a decrease in lymphocyte percentage, hemoglobin concentration, mean corpuscular volume, and hematocrit. (2) Prothrombin time levels were markedly elevated beyond normal reference values, with prolonged prothrombin time identified as a significant predictor for CE. (3) The area under the receiver operating characteristic curve (AUC) for predicting CE based on prothrombin time was 0.969, while the AUC for predicting CE using a combination of prothrombin time and eosinophil percentage was 0.982.Prolonged prothrombin time serves as a crucial indicator for CE, and its combination with eosinophil percentage significantly improves diagnostic accuracy, offering a potentially useful screening strategy in resource-limited endemic regions.
Keywords: Cystic echinococcosis, hematological marker, biochemical markers, laboratory diagnosis, plasminogen time
Received: 20 Apr 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Ma, Yan, Shen, Zhang and Long. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chongwei Zhang, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Juan Long, University of Electronic Science and Technology of China, Chengdu, China
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